Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06069362Recruiting
Manual Physiotherapy for Neck and Arm Pain
This study tests whether a type of hands-on physical therapy (manual therapy) can help reduce neck and arm pain. It looks at how your body senses touch and pressure to see if that predicts how well you respond.
San Sebastián, GipuzkoaAges 18–80 - NCT06874816Recruiting
Neck pain, teeth grinding, and mouth behaviors study
This trial looks at how chronic neck pain is linked to teeth grinding (bruxism) and other mouth-related habits. It aims to see if muscle thickness in your jaw is related to your neck pain.
Istanbul, BeylikdüzüAges 18–65 - NCT06601634Recruiting
Neck pain improvement after cervical spine surgery
This study looks at what factors help predict better neck pain after a specific type of neck surgery called ACDF. If you have a degenerative neck condition and are scheduled for this surgery, the results could help doctors understand what leads to the best pain relief.
Krakow, Lesser Poland VoivodeshipAges 18–65 - NCT06890000Recruiting
Scapular exercises for shoulder pain relief
This trial tests if special exercises for the shoulder blade (scapula) can reduce shoulder pain better than standard exercises. It is for people with shoulder pain that has lasted at least one month and who have a shoulder blade that moves incorrectly.
AnkaraAges 18 years+ - NCT07267819Recruiting
Xeomin for migraines after a brain injury or health incident
This trial looks at whether Xeomin (a shot that relaxes muscles) helps prevent migraines in people who have had a traumatic brain injury or an unexplained health event, such as a blast or sudden illness. It is for U.S. government employees and their families who have already tried Xeomin at a U.S. military or medical facility.
Bethesda, MarylandAges 18 years+ - NCT07262268Enrolling by invitationPhase 1
Testing BHV-7000 for inherited erythromelalgia pain
This clinical trial tests an investigational medication (BHV-7000) for people with inherited erythromelalgia caused by a specific NaV1.7 gene mutation. The study aims to see if the drug can safely reduce the chronic burning pain that is typical of this condition.
New Haven, ConnecticutAges 18–75 - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT05383157Recruiting
Brief mindfulness program for chronic pain in Ukraine
This study tests whether a short mindfulness practice can help people manage long-term (chronic) pain. You may be able to take part if your chronic pain diagnosis is confirmed by a doctor and you can complete the study activities.
VinnitsaAges 18 years+ - NCT05050409Recruiting
Program to help recovery after knee replacement surgery
This trial tests a supportive, coach-like “embedded” program designed to help you stay engaged and ready for recovery after one knee replacement. It may be helpful if you want extra support before and after surgery to follow through with your recovery plan.
Fort Sam Houston, TexasAges 18 years+ - NCT05761275Recruiting
Sexual quality of life after minimally invasive benign surgery
This study looks at how minimally invasive “vNOTES” surgery affects women’s sexual quality of life after a non-cancer (benign) gynecologic procedure. You might be eligible if you recently had this type of surgery and meet specific health, infection, and language requirements.
GenevaAges 18–70 - NCT07260864Recruiting
rTMS for fibromyalgia pain
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce pain in people with fibromyalgia. If you join, you'll receive rTMS sessions and we'll monitor your brain activity to see how it affects your pain.
Rochester, New YorkAges 18–65 - NCT07264699Recruiting
Guided nerve block for hernia repair pain control
This trial tests whether a visually guided nerve block (TAP block) during laparoscopic hernia repair reduces pain and improves recovery. If you are having planned hernia surgery, this study may help you experience less pain after the procedure.
Olsztyn, Warmisko-mazurskieAges 18–80 - NCT07265557Recruiting
Comparing two pain plans after orthopedic surgery
This trial compares two different pain medication plans after major orthopedic surgery. It aims to find which plan helps you recover with less pain and fewer side effects.
Boston, MassachusettsAges 18 years+ - NCT07269106RecruitingPhase 4
Testing anrikefon for pain relief after eye surgery
This trial tests a new painkiller called anrikefon for people having eye surgery under general anesthesia. It aims to see if it's safe and effective for controlling pain after the procedure.
Guangzhou, GuangdongAges 18–70 - NCT07268495Recruiting
Lidocaine spray to reduce pain after fibroid surgery
This trial tests if spraying lidocaine (a numbing medicine) inside the belly along with lidocaine given through an IV can lower pain after surgery to remove uterine fibroids. It may help you have less pain and recover more comfortably.
Yinchuan, NingxiaAges 18–65 - NCT07262632Recruiting
Cancer pain and AI assessment study
This study builds a database of videos and voice recordings from people with cancer, both with and without pain. The goal is to train artificial intelligence (AI) to automatically recognize pain, which could help doctors better manage it in the future.
Rotterdam, South HollandAges 18 years+ - NCT07262944Recruiting
Pain block study for ear surgery with rib cartilage
This study tests a pain-blocking injection during ear surgery to see if it helps reduce pain after the operation. It is for teenagers having ear reconstruction with rib cartilage at a specific hospital.
SeoulAges 13–18 - NCT07266987Recruiting
Multisensory methods for comfort during thyroid biopsy
This study tests whether adding multisensory methods (like calming sounds or visuals) during a thyroid biopsy can make the procedure more comfortable for patients. It involves watching a short video before the biopsy and answering questions about your comfort level.
Muş, CenterAges 18–90 - NCT07260630Enrolling by invitation
Hamstring tightness relief study
This trial tests different massage-type techniques to see which helps tight hamstrings best. If you are between 18 and 30 and have stiff hamstrings, this may help find a quick, drug-free solution.
Ankara, AnkaraAges 18–30 - NCT07266103Recruiting
Personalized brain stimulation for chronic pain study
This study tests whether personalized sessions of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help reduce chronic pain. It aims to understand how this treatment works and how it might be tailored to individuals.
GistrupAges 18–80 - NCT07263516Enrolling by invitation
Pelvic and breathing exercises for period pain
This study tests whether pelvic floor and diaphragmatic breathing exercises can reduce pain during periods. It is for women with primary dysmenorrhea who have not had a pregnancy or childbirth and are not on regular medications.
Istanbul, AvcılarAges 18–25 - NCT07261839Enrolling by invitation
Meditation's effect on anxiety and pain during endoscopy
This study tests whether a guided meditation can help you feel less anxious and more comfortable during an endoscopy procedure. It may be a good fit if you are having an endoscopy for the first time and want a non-drug way to relax.
Gaziantep, ŞehitkamilAges 18 years+ - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT06260072RecruitingPhase 2
Magnesium and Riboflavin for Post-Concussion Headaches
This trial tests if taking magnesium and riboflavin (vitamin B2) can help reduce headaches after a concussion. It is for University of Virginia students who have had a concussion within the past 3 days and can swallow pills.
Charlottesville, VirginiaAges 18–40
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.