Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 11,952 recruiting studies in this area right now.
By phase
- Not applicable9,355
- Phase 2761
- Phase 1558
- Phase 3514
- Phase 4339
- Phase 1/Phase 2300
- Phase 2/Phase 3125
Top conditions
- Stroke798
- Parkinson Disease395
- Alzheimer Disease338
- Multiple Sclerosis328
- Dementia226
- Epilepsy193
- Ischemic Stroke190
- Insomnia159
- Traumatic Brain Injury151
- Obstructive Sleep Apnea142
- Spinal Cord Injuries142
- Acute Ischemic Stroke138
- Sarcopenia134
- Mild Cognitive Impairment127
- Cerebral Palsy119
- Pain Management116
- Migraine107
- Fibromyalgia104
Leading sponsors
- Beijing Tiantan Hospital124
- Assistance Publique - Hôpitaux de Paris109
- Riphah International University105
- Mayo Clinic98
- VA Office of Research and Development92
- Xuanwu Hospital, Beijing89
- Hospices Civils de Lyon77
- Johns Hopkins University69
- University of Minnesota63
- Washington University School of Medicine63
Where studies are running
- California661
- Massachusetts305
- New York295
- Florida272
- Texas266
- Maryland248
- Alabama207
- Arizona206
- Illinois181
- Pennsylvania177
Recruiting studies11,952 total
- NCT07448610RecruitingPhase 4
Real-world safety and effectiveness of gene therapy for spinal muscular atrophy
This study tracks how well the gene therapy ITVISMA works in everyday medical practice for people with spinal muscular atrophy (SMA). It aims to see if the treatment is safe and effective in a real-world setting.
New York, New YorkAges 2–100 - NCT07449416Recruiting
Ceribell Delirium Monitor Study in ICU Patients
This pilot study tests a special brain monitor (called Ceribell EEG) to see if it can help detect delirium in ICU patients. Delirium is a state of confusion that can happen during a serious illness, and this monitor may help doctors catch it early.
Irvine, CaliforniaAges 18 years+ - NCT01950624Recruiting
DS-Connect registry for people with Down syndrome
This is a study registry that collects information from people with Down syndrome (or certain forms like mosaic or partial trisomy 21) and their families. It helps researchers learn about health and needs over time and makes it easier to contact people for future studies.
Aurora, ColoradoAges Any age - NCT04174157Recruiting
Spinal muscular atrophy patient registry for OAV-101
This is a registry that collects information from people with spinal muscular atrophy (SMA) who have been treated with OAV-101. It helps researchers understand how patients do over time after this treatment.
Phoenix, ArizonaAges Any age - NCT04962672Recruiting
Tested anesthesia approach for survival in high-grade brain tumors
This study checks whether a specific anesthesia plan used during surgery is practical and safe for people having their first operation for a high-grade brain tumor. If it works well, it may help support better outcomes after surgery.
Toronto, OntarioAges 18 years+ - NCT06803095Recruiting
Walking with a dog for tinnitus relief in sleep apnea
This study tests whether walking with a dog can help reduce tinnitus complaints in people who have mild sleep apnea and are overweight. It aims to see if this simple, enjoyable activity can improve your symptoms.
Dokki, Giza GovernorateAges 30–45 - NCT06585228Recruiting
Heart CT vs ultrasound to find clots after stroke
This study compares two ways to look for blood clots in the heart after a stroke: a heart CT scan and an ultrasound done through the food pipe. It aims to see if the CT scan can spot clots just as well as the more invasive ultrasound.
Amsterdam, North HollandAges 18 years+ - NCT06379971RecruitingPhase 1
Choline for cannabis use in pregnancy
This trial tests whether taking choline (a vitamin-like nutrient) during pregnancy can help protect the baby's brain development in women who use cannabis. It aims to understand if choline supplementation can reduce potential risks linked to cannabis use.
Aurora, ColoradoAges 18–45 - NCT06488248Recruiting
Comparing two surgeries for fluid buildup in the brain
This study compares two surgical treatments for normal pressure hydrocephalus (fluid buildup in the brain). It tests whether a less invasive procedure (endoscopic third ventriculostomy) works as well as the standard shunt surgery to improve walking, memory, and bladder control.
BaselAges 40 years+ - NCT06733077Recruiting
Digital services for Parkinson's disease
This study is developing digital services for people with Parkinson's disease and also includes healthy volunteers. It aims to understand movement problems like freezing of gait and festination, and uses a virtual reality system to measure these issues.
ExeterAges 18 years+ - NCT06804421Recruiting
Treating stroke-like symptoms after brain bleed
This trial is for people who had a brain bleed from a burst aneurysm and need intensive care. It tests better ways to diagnose and treat delayed brain injury that can happen days or weeks later.
Bergamo, BGAges 18 years+ - NCT04310644Recruiting
Study of nerve and connective-tissue symptoms in EDS and autonomic issues
This study collects information about how the body’s automatic nerves (autonomic nerves) affect symptoms like fast heart rate on standing, fatigue, and related conditions in people with Ehlers-Danlos syndrome. It also enrolls healthy volunteers to compare results, which may help doctors understand these conditions better and improve care.
Aachen, North Rhine-WestphaliaAges 18–80 - NCT06805552Recruiting
Sarcopenia and targeted therapy in liver cancer
This study looks at muscle loss in people with liver cancer who are receiving targeted therapy (TKIs). It aims to understand how muscle health affects treatment outcomes. You may qualify if you have intermediate or advanced liver cancer or earlier stage that hasn't responded to prior treatments.
BolognaAges 18 years+ - NCT06107010Recruiting
Robotic exoskeleton for walking after stroke
This trial tests a robotic exoskeleton (Atalante) to help people who have had a stroke and have trouble walking. It looks at whether using the device early (1–4 months after stroke) can improve the ability to walk again.
CréteilAges 18 years+ - NCT05349006RecruitingPhase 3
Azathioprine for first attack in MOG antibody disease
This Phase 3 trial studies whether azathioprine can help prevent problems after a first attack of MOG antibody–related inflammation of the brain/spinal cord. It’s for adults with a recent first episode and confirmed MOG antibodies.
BordeauxAges 18 years+ - NCT06201611RecruitingPhase 2/Phase 3
Nebivolol for diabetic nerve damage study
This study tests whether the drug nebivolol (a type of beta-blocker) can help slow or reverse nerve damage caused by diabetes. It is for people with recent diabetes and confirmed neuropathy.
Bangalore, KarnatakaAges Up to 18 years - NCT05913531Recruiting
Use of past delirium data from adult patients
This trial looks back at information already collected from past patients, focusing on delirium (confusion that can happen during serious illness or after anesthesia). It doesn’t test a new treatment—its goal is to learn patterns from existing records to improve future care.
BerlinAges 18–100 - NCT06781060Recruiting
Nerve stimulation for sciatic nerve injury in children
This trial tests if electrical nerve stimulation can help children aged 3 to 19 who have nerve damage in the leg caused by an injection. The goal is to improve nerve healing and leg function.
Multan, Punjab ProvinceAges 3–19 - NCT07438054Enrolling by invitation
Yearly heart-rhythm screening for adults 65 and older
This study tests whether monthly heart checks using a simple ECG (a quick test of your heart's electrical activity) can find a common heart-rhythm problem called atrial fibrillation earlier. You would visit your family health center once a month for 12 months to get the ECG done, no extra procedures or treatments are involved.
Ordu, OrduAges 65 years+ - NCT07442188Recruiting
Comparing two numbing blocks for hernia surgery pain
This trial compares two types of numbing injections (nerve blocks) given before hernia surgery to see which one works better for pain after the operation. The blocks target muscles around the belly area to help you feel less pain and recover more comfortably.
Ankara, Yenimahalle\AnkaraAges 18–65 - NCT07436156RecruitingPhase 4
Stroke treatment study using a new clot removal system
This study looks at people who had an ischemic stroke and were treated with a special clot-removal device. It aims to learn how well this treatment works in real-world patients.
West Jordan, UtahAges 18 years+ - NCT07440147Recruiting
Akkermansia and Berberine for night shift workers' insulin sensitivity
This trial tests whether taking a probiotic called Akkermansia muciniphila and a natural plant compound called berberine can improve how your body uses insulin. If you work night shifts regularly, this study may help you find a way to support your metabolic health.
Graz, StyriaAges 21 years+ - NCT07435649Recruiting
New test for finding germs in spinal fluid during brain infections
This study tests a new type of test called Delve Detect that looks for germs in spinal fluid from people suspected of having a brain or spinal cord infection. It helps doctors find the cause faster and more accurately.
San Francisco, CaliforniaAges Any age - NCT07444476RecruitingPhase 3
Study of salanersen for spinal muscular atrophy (ages 15-60)
This trial tests a medicine called salanersen (BIIB115) to see how well it improves movement and how safe it is in people with spinal muscular atrophy (SMA). It includes those who have never taken an SMA drug or are currently on risdiplam and willing to switch.
Palo Alto, CaliforniaAges 15–60
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 11,952 recruiting neurology studies from the U.S. registry right now, out of 18,491 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.