Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04802707RecruitingPhase 2
Study drug for mitochondrial depletion disorder due to gene changes
This Phase 2 trial tests a treatment made from deoxynucleosides to help people with mitochondrial depletion disorder caused by certain gene changes. If you match the genetic diagnosis, the study may see whether the treatment improves symptoms or disease markers.
Montreal, QuebecAges 1 month–60 years - NCT04804202Recruiting
Virtual cycling program for people with Parkinson disease
This study tests whether a virtual, guided stationary bike exercise program is safe and helpful for people with Parkinson disease. It may help improve movement and fitness by letting you ride at home or in a controlled setting while using visual and audio guidance.
Newark, New JerseyAges 45–75 - NCT04804384Recruiting
Testing a brain-controlled hand device after a stroke
This study tests whether a “closed-loop” neuroprosthesis (a hand-control device that responds to your movement) can improve hand grasping after a stroke. It may help people who cannot open or grab objects on their own, and who can safely participate during a short hospital stay.
ToulouseAges 18 years+ - NCT04804618Recruiting
Study uses blood protein changes in memory loss and Alzheimer’s
This trial studies blood “protein fingerprints” in people with mild memory problems or Alzheimer’s disease to better understand what’s happening. It may help researchers find ways to measure the condition and improve care over time.
Guangzhou, GuangdongAges 55 years+ - NCT04805255Recruiting
Study brain-targeted radiation for limited brain metastases
This study looks at people with a small number of brain metastases who are treated with a focused, staged form of radiation after surgery or to treat the cancer. It may help doctors better understand how well this approach works and who benefits most.
TaoyuanAges 18–84 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT04806568Recruiting
Cognitive training to help brain flexibility in multiple sclerosis
This study tests whether structured cognitive exercises can improve “neuroplasticity,” meaning how flexible and changeable the brain is. It includes people with multiple sclerosis and healthy volunteers, and uses tasks plus brain scans to see what changes over time.
Thessaloniki, Central MacedoniaAges 18–65 - NCT04811209Recruiting
Testing better pain control and recovery after orthopedic surgery
This trial looks at how well a pain-control plan works after certain orthopedic surgeries and how it affects recovery and patient-reported outcomes. It may help determine what level of pain relief is meaningful to patients after surgery.
Toronto, OntarioAges 18–80 - NCT04812431RecruitingPhase 1/Phase 2
Tested stem cell transplant therapy for severe spinal cord injury
This trial tests a cell transplant approach for people with a very severe spinal cord injury. It focuses first on safety and also looks for early signs the therapy may improve function.
Suwon, GyeonggidoAges 18–65 - NCT04814420Recruiting
Study heart scarring in sleep apnea, with or without atrial fibrillation
This pilot study looks at whether obstructive sleep apnea leads to heart scarring (called atrial fibrosis), especially in people with and without an irregular heart rhythm (atrial fibrillation). It may help researchers understand who is at higher risk and why, using sleep testing and heart imaging.
New Orleans, LouisianaAges 18–75 - NCT04815889Recruiting
Early help for preschool children with developmental or behavior concerns
This trial tests an early detection and support program for preschool children who show developmental delays or behavior and self-regulation challenges. It may help by starting support sooner and targeting everyday communication, behavior, and functioning needs.
Eksjö, Jönköping CountyAges 1.5 years–6 years - NCT04816227Recruiting
Study of immune cells in ALS and related movement problems
This study looks at immune cells (called macrophages) from people with ALS and certain related movement or nerve conditions. It aims to better understand how the disease works and may help researchers design future treatments.
ParisAges 18 years+ - NCT04817163Recruiting
Testing a CBT-I sleep program in cancer clinics
This trial tests whether a structured sleep program called CBT-I can help people with non-metastatic cancer sleep better. It may help by teaching practical, evidence-based steps for insomnia in a cancer-clinic setting.
QuébecAges 18 years+ - NCT04819737Recruiting
MRI scan study to better detect spinal cord changes in MS
This study tests new MRI scan methods to more clearly find spinal cord lesions in people with multiple sclerosis (MS). It may help improve how MS spinal cord changes are seen on scans.
BaselAges 18 years+ - NCT04824482Recruiting
Robot training to improve walking after a recent stroke
This study tests a robot-assisted walking program for people recovering after an acute ischemic stroke. It aims to improve how safely and independently you can walk during recovery.
OlomoucAges 18–80 - NCT04824144RecruitingPhase 1/Phase 2
Dexmedetomidine for agitation in palliative care delirium
This trial tests whether dexmedetomidine can help calm agitation caused by delirium in adults receiving palliative (comfort-focused) care. It may help reduce restlessness and distress when standard approaches may not be enough.
Calgary, AlbertaAges 18 years+ - NCT04829071RecruitingEarly Phase 1
Testing brain and movement training after a one-sided stroke
This early research study looks at a way to improve thinking and movement after a stroke that happened more than 6 months ago. It may help people who still have problems using one side of their body to walk and learn new movement skills.
Los Angeles, CaliforniaAges 45–85 - NCT04828798Recruiting
Directional versus standard brain stimulation for essential tremor
This study compares two ways of delivering deep brain stimulation (DBS) to treat essential tremor that affects both arms. It may help find a DBS approach that better controls tremor while reducing side effects.
Portland, OregonAges 18–80 - NCT04829526Recruiting
Study of suspected Guillain-Barré syndrome cases
This is an observational study that looks at people who were suspected to have Guillain-Barré syndrome and were cared for at University Hospital of Basel in the past. It does not test a new treatment—researchers review existing care to learn more about this condition.
BaselAges 18 years+ - NCT04832100Recruiting
Study of a fat marker in fibromyalgia
This study looks at whether a specific fat-related marker (called LPC16:0) is linked to fibromyalgia. Your participation could help researchers understand what role this marker may play in the condition.
Kaohsiung CityAges 18–70 - NCT04831385Recruiting
CBT-I sleep therapy to improve blood sugar in older adults
This study tests whether a structured therapy for insomnia (CBT-I) can help improve blood sugar control in older adults with type 2 diabetes. It targets people who have both high blood sugar levels and troublesome insomnia, aiming to see if better sleep improves glycemic measurements.
Hong KongAges 60 years+ - NCT04833894RecruitingPhase 2/Phase 3
Efgartigimod for children with generalized myasthenia gravis
This trial studies how efgartigimod (given through a vein) behaves in children and whether it is safe and effective for generalized myasthenia gravis. It is designed for children who have not done well enough with standard treatments like steroids or other immune medicines.
Chicago, IllinoisAges 2–18 - NCT04832568Recruiting
EEG monitoring to predict and prevent postoperative delirium
This study checks brain-wave signals during heart surgery (using EEG monitoring) to understand who is at risk for confusion after surgery. If you qualify, your team will track your thinking after the operation to help reduce or better manage postoperative delirium.
Wuhan, HubeiAges 18 years+ - NCT04833335Recruiting
MRI scans to tell tumor spread from radiation injury
This trial studies how a special MRI can help doctors tell whether brain lesions after Gamma Knife treatment are growing tumors or radiation injury. It may help you avoid unnecessary treatment if the findings suggest radionecrosis instead of progression.
ParisAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.