Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,516 recruiting studies in this area right now.
By phase
- Not applicable9,855
- Phase 2786
- Phase 1573
- Phase 3533
- Phase 4344
- Phase 1/Phase 2305
- Phase 2/Phase 3120
Top conditions
- Stroke852
- Parkinson Disease423
- Alzheimer Disease341
- Multiple Sclerosis340
- Dementia230
- Ischemic Stroke202
- Epilepsy197
- Insomnia156
- Obstructive Sleep Apnea156
- Traumatic Brain Injury156
- Spinal Cord Injuries152
- Sarcopenia151
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine112
- Pain Management112
- Amyotrophic Lateral Sclerosis106
Leading sponsors
- Beijing Tiantan Hospital134
- Riphah International University127
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon80
- Johns Hopkins University71
- National Taiwan University Hospital71
- University of Minnesota65
Where studies are running
- California678
- Massachusetts307
- New York295
- Florida274
- Texas271
- Maryland245
- Alabama214
- Arizona209
- Illinois193
- Pennsylvania177
Recruiting studies12,514 total
- NCT04681781Enrolling by invitation
Remote study of SLC13A5 deficiency history
This study follows people with SLC13A5 deficiency to better understand how the condition changes over time, using surveys and clinical check-ins done remotely. If you (or your child) have this genetic condition, it may help researchers learn what symptoms to expect and how to track them.
Palo Alto, CaliforniaAges Any age - NCT04680130Enrolling by invitation
Study of brain, genetics, and clinical symptoms in neurodegenerative illness
This study looks at how your symptoms, brain imaging (MRI), and genetic factors relate to neurodegenerative conditions. It may help researchers better understand what causes these illnesses and how to classify them.
Rochester, MinnesotaAges 21 years+ - NCT04676204Enrolling by invitation
How MS treatment “burden” may affect taking medicines
This study looks at whether the amount of MS treatment-related “burden” in the mouth and body affects how well people stick to their disease-modifying therapy. It may help doctors understand which patients are more likely to have trouble following treatment after switching or starting certain MS medicines.
Melbourne, VictoriaAges 18–99 - NCT04673565Enrolling by invitation
Coaching new hearing-aid users to use them more
This study tests whether motivational interviewing (a supportive coaching conversation) can help people who are new to hearing aids wear and use them more successfully. It uses online questionnaires to understand hearing-aid use and comfort.
Vancouver, British ColumbiaAges 18 years+ - NCT04672174Enrolling by invitation
Cognitive screening study for adults with hearing loss
This study checks how well people with hearing loss perform on thinking and memory tests (cognitive screening). It may help researchers find better ways to spot thinking changes in people with hearing loss and understand what factors are involved.
Zurich, Canton of ZurichAges 50–90 - NCT04625049Enrolling by invitation
PET and MRI study in people with multiple sclerosis
This trial studies how certain brain immune activity relates to multiple sclerosis (MS) lesion growth and progression using PET and MRI scans. Your participation may help researchers understand disease changes over time and improve how MS is tracked.
Turku, Southwest FinlandAges 30–80 - NCT04607369Enrolling by invitation
Test using an app to map eye vision blind spots
This trial tests how well an EyeCTester smartphone app can measure vision blind spots and distorted vision compared with standard eye tests. If you qualify, you’ll do short near-vision and “Amsler grid” style tasks in the clinic to help confirm the app is accurate.
Bellaire, TexasAges 18 years+ - NCT04605263Enrolling by invitation
Deep brain stimulation for Parkinson’s walking and falls
This study tests a brain surgery treatment (deep brain stimulation) to help improve gait problems such as freezing of walking, gait instability, or falls in people with Parkinson’s disease. It may help people whose walking symptoms are not well controlled by levodopa (a common Parkinson’s medicine).
Phoenix, ArizonaAges 18–75 - NCT04566341Enrolling by invitation
Study gut problems in Parkinson’s and changes in gut nerves
This study looks at how digestive (gut) problems happen in people with Parkinson’s and whether there are related changes in the nerve tissue in the digestive tract. It may help researchers better understand the cause of these symptoms and find new ways to monitor or treat them.
Boston, MassachusettsAges 40–85 - NCT04565366Enrolling by invitation
Study of research care for new spinal cord injuries
This study looks at people after a recent, serious injury—especially a new spinal cord injury—to see how research and clinical knowledge can be improved. Depending on your group (spinal cord injury, other trauma, or healthy), you may be invited to participate if you meet age and injury timing needs.
Fresno, CaliforniaAges 18 years+ - NCT04534556Enrolling by invitation
Wireless nerve stimulation to improve stroke recovery
This study tests a wireless nerve stimulation device placed near the vagus nerve to help people recover after a stroke. It focuses on people with specific remaining arm/hand movement and recovery levels at least 12 months after stroke.
Dallas, TexasAges 22–79 - NCT04504721Enrolling by invitation
Light therapy for fibromyalgia using blue-enriched white light
This study tests whether a specific type of light (blue-enriched white light) can reduce symptoms of fibromyalgia. It may help people feel better by changing how the body responds to light.
TaipeiAges 20–64 - NCT04503213Enrolling by invitation
Testing CSF1R brain disease after stem cell transplant
This study looks at how CSF1R-related leukoencephalopathy (a genetic brain condition) behaves after a stem cell transplant. It may help doctors understand expected brain and walking changes after treatment.
Jacksonville, FloridaAges 18 years+ - NCT04498026Enrolling by invitation
Sealant tested to help close a spinal fluid leak opening
This study tests a glue-like dural sealant (Adherus™) to help seal and protect the covering around the spinal cord after a planned opening. It may help prevent or reduce problems related to spinal fluid leaking after certain elective spinal surgeries.
Duarte, CaliforniaAges 18–75 - NCT04444778Enrolling by invitation
Study intermittent low oxygen in sleep apnea
This study looks at how repeated episodes of low oxygen during sleep affect the body in people with severe sleep apnea. It may help researchers understand what causes symptoms and long-term risks, which could guide better treatment decisions.
Palma, Balearic IslandsAges 18–65 - NCT04417023Enrolling by invitation
Study for people with neuromuscular diseases
This study is for people (or their close family members) who have a neuromuscular disease, such as motor neuron disease, neuropathies, nerve-to-muscle signaling problems, or muscle diseases. It aims to better understand these conditions and how to move from lab findings to care for patients.
Ottawa, OntarioAges 18 years+ - NCT04415372Enrolling by invitation
MRI brain scan study for white and gray matter in MS
This study uses detailed MRI scans to look at brain “white matter” and “gray matter” changes in people with multiple sclerosis (MS). It may help researchers better understand how MS affects the brain and relates to symptoms.
Madison, WisconsinAges 18–60 - NCT04382807Enrolling by invitation
Online group counseling for long-term ringing in the ears
This trial tests an internet-based group counseling program for people who have had ongoing (chronic) tinnitus—ringing or other sounds in the ears. It may help you learn coping strategies and reduce how much the condition affects your daily life.
AntwerpAges 18 years+ - NCT04348708Enrolling by invitation
Long-term follow-up after receiving HMI 102
This study checks how people are doing long-term after they previously received a treatment called HMI 102. It may help researchers understand long-term safety and outcomes so future patients can be better supported.
Boston, MassachusettsAges 18–55 - NCT04309305Enrolling by invitationPhase 1
Robotic brace walking training for people shortly after stroke
This Phase 1 trial tests a robotic exoskeleton device that helps stroke survivors practice walking. It may help you relearn walking safely and see whether the device is workable for your body and needs.
West Orange, New JerseyAges 21–80 - NCT04258774Enrolling by invitation
Breathing challenge during MRI to test brain blood-flow signals
This study uses a breathing challenge while you’re in an MRI to see how blood flow signals in the brain change. It may help researchers better understand how brain imaging signals respond to breathing and oxygen/carbon dioxide levels.
St Louis, MissouriAges 18 years+ - NCT04240119Enrolling by invitation
Study blood vessel growth markers in certain brain artery narrowing
This study looks at “angiogenic markers,” which are blood measures that may reflect how blood vessels grow, in people with significant narrowing of a brain artery. It aims to better understand these changes and how they relate to cerebrovascular disease.
Ages 18 years+ - NCT04129229Enrolling by invitation
Tongue device study for moderate-to-severe sleep apnea and snoring
This trial tests a tongue retractor device to help treat obstructive sleep apnea and reduce snoring in adults. You may be eligible if you have moderate-to-severe sleep apnea and can avoid other common treatments during the study.
Brighton, MassachusettsAges 18 years+ - NCT04104659Enrolling by invitation
Tau PET scan study to map brain changes in Alzheimer’s
This study tests a PET scan “tracer” medicine called [18F]MK-6240 to see how tau protein changes show up in the brain. It may help researchers measure disease-related brain changes in people with normal thinking or mild dementia.
St Louis, MissouriAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,516 recruiting neurology studies from the U.S. registry right now, out of 20,061 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.