Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,516 recruiting studies in this area right now.
By phase
- Not applicable9,855
- Phase 2786
- Phase 1573
- Phase 3533
- Phase 4344
- Phase 1/Phase 2305
- Phase 2/Phase 3120
Top conditions
- Stroke852
- Parkinson Disease423
- Alzheimer Disease341
- Multiple Sclerosis340
- Dementia230
- Ischemic Stroke202
- Epilepsy197
- Insomnia156
- Obstructive Sleep Apnea156
- Traumatic Brain Injury156
- Spinal Cord Injuries152
- Sarcopenia151
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine112
- Pain Management112
- Amyotrophic Lateral Sclerosis106
Leading sponsors
- Beijing Tiantan Hospital134
- Riphah International University127
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon80
- Johns Hopkins University71
- National Taiwan University Hospital71
- University of Minnesota65
Where studies are running
- California678
- Massachusetts307
- New York295
- Florida274
- Texas271
- Maryland245
- Alabama214
- Arizona209
- Illinois193
- Pennsylvania177
Recruiting studies12,514 total
- NCT05116137Enrolling by invitation
Exercise therapy to build muscle after glioblastoma
This trial studies whether a resistance (strength-building) exercise program can help survivors of glioblastoma keep or increase their muscle mass. If you are able to safely exercise, it may support recovery and overall strength after treatment.
Halifax, Nova ScotiaAges 18 years+ - NCT05115461Enrolling by invitation
Study pain and balance in lumbar disc nerve pain
This trial studies how nerve pain from a slipped/herniated low-back disc affects postural (balance) stability. It may help researchers understand better ways to support balance and reduce nerve-related pain symptoms.
IzmirAges 18–60 - NCT05110183Enrolling by invitation
Bionic ear implant surgery for certain inner-ear nerve tumors
This study looks at a special “opto-electrical” cochlear implant for people who need a specific type of tumor-removal surgery near the facial nerve and hearing structures. It may help restore hearing in people whose hearing is already severely reduced and who meet the tumor and hearing-size criteria.
Coral Gables, FloridaAges 18–89 - NCT05066711Enrolling by invitation
Study of a neck surgery implant for adults
This trial looks at using a specific implant system during planned front-of-the-neck surgery (C2 to C7) for common neck problems like disc degeneration, injury, or spinal narrowing. It may help doctors compare outcomes with this particular hardware and surgical approach.
Naperville, IllinoisAges 18 years+ - NCT05064891Enrolling by invitation
Ultrasound therapy for shoulder movement after stroke
This trial studies whether using ultrasound on a shoulder nerve (the suprascapular nerve) and guided shoulder movement exercises can improve shoulder motion in people after a stroke. It may help if your biggest problem is pain and limited shoulder movement after stroke.
TaipeiAges 20–80 - NCT05014841Enrolling by invitation
Brain electrode study of speech across different languages
This study uses electrodes placed on the brain during surgery to understand how speech is represented in different languages. It may help doctors better map language areas and improve surgical planning for people having brain surgery.
San Francisco, CaliforniaAges 18–70 - NCT04994847Enrolling by invitation
Study APOE-related brain changes to help prevent Alzheimer’s
This study looks at how a person’s APOE gene relates to early brain and health changes that could lead to Alzheimer’s. If you are not currently having memory or thinking problems, you may be asked to do brain scans, cognitive testing, and blood plus a spinal fluid sample to support research.
Phoenix, ArizonaAges 50–90 - NCT04982731Enrolling by invitation
Testing reassurance support after a concussion in teens
This study looks at whether a specific reassurance program (“Positive Assurance”) helps teens recover better after a mild concussion. Teens are checked for concussion symptoms, then assigned to different support approaches to see which helps most.
Falls Church, VirginiaAges 13–21 - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT04929457Enrolling by invitation
Screening to detect inherited high cholesterol
This study tests a digital screening method to help identify and diagnose familial hypercholesterolemia, an inherited condition that can cause very high cholesterol. If you participate, you may be invited to complete screening steps to see whether they can find the condition early.
StockholmAges Any age - NCT04905238Enrolling by invitation
Sleep apnea study linking breathing markers to memory changes
This trial looks at how severe sleep apnea breathing patterns relate to body “biomarkers” linked to Alzheimer’s disease, using blood or other measures. It may help researchers understand whether sleep apnea is connected to memory and brain health—and who might benefit most from better sleep care.
Palma, Balearic IslandsAges 18–65 - NCT04903535Enrolling by invitation
Nitric oxide test using a skin measurement method
This study measures a substance called nitric oxide (related to blood vessel function) by checking how it changes in skin samples. It mainly needs volunteers who are not pregnant and can safely provide the required samples, to help researchers understand how well this measurement method works.
Indianapolis, IndianaAges 1 day–75 years - NCT04886492Enrolling by invitation
NMOSD patient registry to help study future treatments
This is a registry that collects health information from adults with neuromyelitis optica spectrum disorder (NMOSD). It aims to better understand NMOSD and support future research, including studies of emerging therapies.
Waltham, MassachusettsAges 18 years+ - NCT04869813Enrolling by invitation
MRI study in heart failure and healthy adults
This study uses an MRI scan to better measure muscle loss (sarcopenia) and heart function. It may help researchers find clearer ways to assess these conditions and track changes over time.
Cleveland, OhioAges 40 years+ - NCT04866459Enrolling by invitation
Myo-MRI scan study for neuromuscular muscle diseases
This study tests whether special MRI scans can help evaluate neuromuscular (muscle/nerve) diseases. It may help doctors better assess muscle involvement and support diagnosis and evaluation.
Ottawa, OntarioAges 18 years+ - NCT04840030Enrolling by invitation
Preventing Memory and Thinking Decline With Multidomain Program
This study tests a multi-part program (not just one activity) to help slow down memory and thinking decline in older adults at higher risk. You would complete brief thinking tests and follow the study’s coaching/intervention schedule to see if it helps over time.
Donostia / San Sebastian, GipuzkoaAges 60–85 - NCT04833907Enrolling by invitationPhase 1/Phase 2
Gene therapy study for typical Canavan disease in children
This early-phase trial tests a gene therapy medicine (delivered by a one-time infusion) for children with typical Canavan disease. It aims to improve safety and help evaluate whether the treatment may benefit children over time.
Dayton, OhioAges 3 months–5 years - NCT04804293Enrolling by invitation
Testing a wrist scan for carpal tunnel before treatment
This study checks whether a special ultrasound scan can help assess carpal tunnel in one wrist (not both). The results may guide doctors’ understanding of the condition before you get a steroid shot or surgery.
Scottsdale, ArizonaAges 18–100 - NCT04788628Enrolling by invitation
Sound stimulation study for sleep and memory in epilepsy
This trial studies whether carefully timed sound (“auditory stimulation”) can change sleep patterns and memory in people with epilepsy. It may help researchers understand how to improve thinking and memory by adjusting how the brain sleeps.
Boston, MassachusettsAges 12–65 - NCT04786223Enrolling by invitationPhase 2
Testing an anti-inflammatory PET imaging treatment in memory loss
This Phase 2 study tests whether targeting “neuroinflammation” (inflammation in the brain) can help in Alzheimer’s disease and related memory disorders. You may help researchers by doing several brain scans (including a special PET/CT scan) along with MRI and amyloid imaging to understand what’s happening in the brain.
Rochester, MinnesotaAges 60 years+ - NCT04770571Enrolling by invitation
Study of posterior neck and upper-back spine fixation systems
This trial studies specific surgical hardware used to stabilize the back of the neck and upper back during spine surgery. It may help surgeons compare outcomes for people needing fixation for trauma, instability, failed prior fusion, tumors, or certain degenerative conditions.
Orange, CaliforniaAges 18 years+ - NCT04755309Enrolling by invitation
Early rhythmic activities for Italian-speaking infants
This trial studies whether starting a rhythmic play/intervention early in life can support healthy babies’ development, including language-related outcomes. It enrolls specific infant ages and looks for certain family-language risk backgrounds while excluding some health and genetic/neurodevelopment conditions.
Bosisio Parini, LCAges 6 months–9 months - NCT04701177Enrolling by invitation
Smartphone-based study of brain biomarkers in memory clinic patients
This observational study follows people with (or at risk for) Alzheimer’s-related brain changes and a comparison group without them. It uses clinic visits, cognitive testing, questionnaires, and possibly a spinal fluid test to better understand brain biomarkers and how they relate to thinking and daily life.
Corfu, CorfuAges 45 years+ - NCT04684901Enrolling by invitation
AlloWrap to reduce inflammation during cervical spine fusion surgery
This trial tests whether AlloWrap® can lower inflammation during anterior cervical fusion surgery (ACDF). It may help improve healing and recovery by reducing the body’s inflammatory response after surgery.
San Diego, CaliforniaAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,516 recruiting neurology studies from the U.S. registry right now, out of 20,061 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.