Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,613 recruiting studies in this area right now.
By phase
- Not applicable7,634
- Phase 2471
- Phase 4471
- Phase 3438
- Phase 1350
- Phase 1/Phase 2161
- Phase 2/Phase 388
Top conditions
- Stroke796
- Heart Failure535
- Hypertension389
- Cardiovascular Diseases374
- Coronary Artery Disease362
- Multiple Myeloma328
- Atrial Fibrillation259
- Ischemic Stroke190
- Atrial Fibrillation (AF)154
- Acute Ischemic Stroke139
- Pulmonary Hypertension104
- Myocardial Infarction96
- Congenital Heart Disease83
- Peripheral Arterial Disease80
- Stroke, Ischemic77
- Aortic Valve Stenosis76
- Obesity74
- Acute Coronary Syndrome73
Leading sponsors
- Mayo Clinic93
- Assistance Publique - Hôpitaux de Paris88
- National Taiwan University Hospital67
- China National Center for Cardiovascular Diseases60
- Second Affiliated Hospital, Zhejiang University, School of Medicine58
- Beijing Tiantan Hospital53
- Insel Gruppe AG, University Hospital Bern49
- Massachusetts General Hospital49
- Yonsei University48
- Johns Hopkins University45
Where studies are running
- California449
- Alabama195
- Arizona182
- Massachusetts174
- New York166
- Florida141
- Texas122
- Maryland118
- Minnesota118
- Illinois111
Recruiting studies9,613 total
- NCT06793969Recruiting
New method to close PFO hole in heart
This trial is testing a new way to close a small hole in the heart (called a PFO) using a thin tube and a guidewire to make the procedure smoother. It's for people who have had a stroke or mini-stroke and whose PFO is thought to be the cause.
ShanghaiAges 18–65 - NCT06794190Recruiting
Understanding liver health in Turner syndrome
This study aims to understand why some women with Turner syndrome develop liver problems. Researchers will analyze factors that may contribute to liver changes, which could lead to better monitoring and care.
BolognaAges 18 years+ - NCT07459244Recruiting
ECG changes in people who use methamphetamine
This study looks at the electrical activity of the heart (ECG) in people who use methamphetamine, including those who develop psychosis from it. It compares them to healthy volunteers to see if methamphetamine affects heart function.
Elâzığ, ElâzığAges 18–65 - NCT06794684Recruiting
Watching Plaque in Heart Arteries Over Time
This study uses CT scans and special camera images inside your arteries to watch how plaque buildup in heart arteries changes over time. It may help you understand your risk and guide future treatment.
ShanghaiAges 18 years+ - NCT07458191Recruiting
Apixaban safety and adherence for atrial fibrillation patients
This trial tests how well patients with atrial fibrillation take their apixaban medication and whether it is safe. It aims to see if using apixaban for the first time works well without causing bleeding problems.
SarajevoAges 18 years+ - NCT07453888RecruitingPhase 3
Nose spray for sudden vision loss from optic nerve damage
This trial tests a nose spray medication (cenegermin) for people who recently lost vision due to a specific type of optic nerve damage (NAION). The goal is to see if it can help restore sight when started within two weeks of vision loss.
Los Angeles, CaliforniaAges 50–80 - NCT07455851RecruitingPhase 1/Phase 2
Studying a new drug combo for relapsed or refractory multiple myeloma
This trial tests whether REGN17372 plus linvoseltamab is safe for people with multiple myeloma that has come back or not responded to prior treatments. You may join if you have tried at least 3 other therapies.
Randwick, New South WalesAges 18 years+ - NCT07456826Enrolling by invitationPhase 4
Comparing two eye numbing gels for shots
This trial tests a new eye-numbing gel against the standard numbing method to see which works better for patients getting regular anti-VEGF injections in the eye.
Tyler, TexasAges 18 years+ - NCT07454187RecruitingPhase 1/Phase 2
SG2918 for relapsed or refractory multiple myeloma
This trial tests a new drug called SG2918 for people with multiple myeloma that has come back or stopped responding to treatment. It aims to see if the drug is safe and possibly effective.
Zhengzhou, HenanAges 18–80 - NCT07454980Recruiting
Tricuspid valve replacement for severe leakage (TRINITY trial).
This trial tests a new catheter-based replacement for the tricuspid valve, which controls blood flow from the body into the heart. It aims to help people with severe tricuspid regurgitation (a leaky valve) who still have symptoms despite medication.
Naples, FloridaAges 21 years+ - NCT07455747Recruiting
Study of a new system for treating carotid artery disease
This study is testing a special system (ENROUTE Transcarotid Neuroprotection) used with a stent to treat narrowed carotid arteries, which can help prevent stroke. It looks at how well the system works in real medical settings.
St Louis, MissouriAges 18 years+ - NCT04262830Recruiting
Heart scans to predict future heart failure after chemotherapy
This trial uses detailed heart imaging (a special MRI scan) to see how chemotherapy may have affected your heart and to predict who could develop heart failure later. If you qualify, it may help your care team better monitor your heart health over time.
San Diego, CaliforniaAges 13–39 - NCT06051032Recruiting
Comparing balloon vs. suction for clotted dialysis fistulas
This study compares two ways to clear a sudden clot in a dialysis fistula (AVF). It uses either a balloon (to push the clot out) or a suction device (to pull the clot out) to restore blood flow.
Valencia, ValenciaAges 18 years+ - NCT04449198RecruitingEarly Phase 1
Study for mitochondrial and blood-vessel issues in type 1 diabetes
This early study looks at how a new approach may affect energy-making (mitochondria) and blood-vessel signaling in people with insulin-dependent type 1 diabetes. It may help researchers understand whether these pathways can be improved in type 1 diabetes.
Augusta, GeorgiaAges 18 years+ - NCT05715710Recruiting
MRI and brain vein pattern study for memory and thinking problems
This study looks at whether certain deep brain veins seen on MRI are linked to thinking and memory problems in people with small-vessel brain disease. It compares brain scan findings with cognitive (thinking) testing to better understand what may drive cognitive dysfunction.
Zigong, SichuanAges 50–85 - NCT06472414Recruiting
Heart rehab program designed for women
This study tests a heart rehab program designed just for women. It aims to help women stick with rehab, get stronger, and feel better. You may be eligible if you have a stable heart condition and are ready to exercise.
LisbonAges 18 years+ - NCT05866874Recruiting
Watching heart warning signs after non-heart surgery
This study checks whether close monitoring of vital signs around the time of non-cardiac surgery can help identify small heart injuries (called perioperative myocardial infarction or injury). It may help doctors spot people at higher risk sooner, especially after certain major surgeries.
Basel, Canton of Basel-CityAges 40–85 - NCT06080178RecruitingPhase 4
Goal-directed fluids during breast reconstruction surgery
This trial tests a precise fluid management strategy during DIEP flap breast reconstruction to improve outcomes. It aims to reduce complications and improve recovery.
Ghent, East FlandersAges 18–70 - NCT06374667Recruiting
Skull bone injection vs. IV for large stroke
This trial tests a new way to give medicine for a large stroke on one side of the brain. The medicine is injected into the skull bone instead of through a vein, and researchers want to see if it works better and is safe.
Wuhu, AnhuiAges 18–80 - NCT07460219Enrolling by invitation
Pharmacist-led heart failure medication study for VA clinics
This trial tests if pharmacists in VA regions can help adjust heart failure medications. It may improve how patients are treated.
Palo Alto, CaliforniaAges 18 years+ - NCT07456280Recruiting
Early discharge after TAVI using heart monitoring
This study tests if patients who have mild heart electrical changes after TAVI can be sent home early with a portable heart monitor instead of staying in the hospital. It aims to see if this approach is safe and effective.
BarcelonaAges 18 years+ - NCT07460531Recruiting
Physical activity and heart health in chronic heart failure
This study looks at how physical activity affects heart outcomes in people with chronic heart failure. If you have a pedometer or activity tracker, you may be able to join.
Munich, BavariaAges 18 years+ - NCT07454382RecruitingPhase 2
Study of elranatamab and cyclophosphamide for multiple myeloma
This trial studies a new medicine called elranatamab combined with the chemotherapy drug cyclophosphamide for people with multiple myeloma that has returned or not responded to prior treatments. It may be a good option if you have aggressive or high-risk myeloma.
Basking Ridge, New JerseyAges 18 years+ - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,613 recruiting cardiology studies from the U.S. registry right now, out of 14,690 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Pain
- Injuries & trauma
- Mouth & dental
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.