Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT04504188Recruiting
Adjusting beta-blocker dose for women using a wearable defibrillator
This trial checks whether doctors can use a lower or adjusted dose of beta-blocker medicine in women who are wearing a wearable defibrillator (WCD). It aims to find an approach that’s safe and works while you’re using the device for about 3 months to protect your heart.
Cincinnati, OhioAges 18 years+ - NCT04505865Recruiting
Mindfulness program to reduce inflammation in heart disease
This trial studies whether a mindfulness (stress-reducing) program can lower “vascular inflammation” (inflammation in blood vessel walls) in people with stable coronary disease. It may help by improving stress and related inflammation markers while you stay on your usual heart medicines.
Boston, MassachusettsAges 45–65 - NCT04507178RecruitingPhase 2
Nadroparine to improve recovery after bleeding in the brain
This study tests whether nadroparine (a blood-thinning medicine) can improve outcomes after a type of brain bleed called subarachnoid hemorrhage. It focuses on people who have had a brain aneurysm treated with a procedure soon after the bleed.
AmsterdamAges 18 years+ - NCT04511234Recruiting
Sirolimus-coated balloon vs standard balloon for leg artery narrowing
This trial compares two balloon treatments used during a procedure to open blocked or narrowed arteries in the thigh and behind the knee. It tests whether the sirolimus-coated balloon works better at keeping the artery open than a standard balloon.
SingaporeAges 21 years+ - NCT04508790RecruitingPhase 2
Leflunomide plus pomalidomide with dexamethasone for relapsed myeloma
This trial studies whether a combination of three medicines (leflunomide, pomalidomide, and dexamethasone) can better treat multiple myeloma that has come back or stopped responding. It may help people who are not good candidates for transplant and who have measurable disease.
Duarte, CaliforniaAges 18 years+ - NCT04511247Recruiting
Drug-coated balloon for artery disease below the knee
This trial tests a drug-coated balloon to open narrowed or blocked arteries in the lower leg (below the knee) and help them stay open. It’s meant for people with significant symptoms, to reduce re-narrowing after treatment.
SingaporeAges 21 years+ - NCT04511572Recruiting
Middle artery embolization for chronic brain bleeding
This study tests a procedure called middle meningeal artery embolization for people with a confirmed chronic subdural hematoma (a long-lasting bleed near the brain). It may help by reducing the blood supply to the area and improving symptoms after symptoms start or worsen.
AmsterdamAges 50–90 - NCT04513639RecruitingPhase 2/Phase 3
Checking treatment for multiple myeloma after MRD becomes negative
This study looks at whether people with newly diagnosed multiple myeloma can safely continue or adjust treatment after they reach “MRD-negative,” meaning very low signs of disease in the bone marrow. It may help reduce the chance of relapse while avoiding unnecessary treatment for some patients.
ÅlesundAges 18–75 - NCT04513054Recruiting
Genetic study for stress-related heart muscle weakness
This study looks for a possible inherited (genetic) reason some people develop Takotsubo cardiomyopathy after severe stress. If you’ve had this condition, the study may help explain why it happens and whether families could be at higher risk.
Aberdeen, AberdeenshireAges Any age - NCT04514445Recruiting
Study of genes in people with bicuspid aortic valve
This study looks for genetic (inherited) differences that may be linked to bicuspid aortic valve (BAV). It includes people with BAV and close family members to help understand why BAV happens and whether genes play a role.
KetteringAges 10–99 - NCT04517383Recruiting
Sedation after clot-removal brain procedure: which helps recovery
This trial compares different types of calming medicine (sedation) after a procedure to remove a brain blood clot. It aims to see whether post-procedure sedation can improve recovery in people with a serious type of stroke.
ShanghaiAges 18–85 - NCT04520048Recruiting
Blood vessel tests to predict preeclampsia worsening in pregnancy
This study measures blood vessel–related markers in pregnant people who already have high blood pressure or early preeclampsia. The goal is to predict who is more likely to get worse, so care can be better targeted.
Bobigny, Seine Saint DenisAges 18–40 - NCT04520126Recruiting
Olive extract for blood vessel and heart function after heart procedures
This trial tests whether an olive extract supplement (Olivomed) improves how your blood vessels, heart, and circulation work. It focuses on people with stable or recently treated coronary heart disease and certain cholesterol patterns.
Athens, AtticaAges 18–70 - NCT04521790Recruiting
Biopsy-guided treatment for suspected inflammation of the heart
This study looks at people 18 and older with suspected myocarditis (inflammation of the heart). It uses an inner-heart biopsy and tailored treatment based on the likely cause to improve diagnosis and care, especially for people with different heart rhythm or non-rhythm symptoms.
Milan, MilanoAges 18 years+ - NCT04521699Recruiting
CalmiGo stress device to improve heart blood vessel health
This study looks at whether a stress-management device (CalmiGo) can improve blood vessel function and heart disease risk in people recovering from recent heart procedures. You would use the device for 12 weeks and complete questionnaires, blood tests, and a heart-vessel test at the start and end.
Rochester, MinnesotaAges 18 years+ - NCT04522622RecruitingPhase 4
Teriparatide for low bone turnover in advanced kidney disease
This trial tests teriparatide (a hormone-like bone medicine) to improve bone health in people with advanced chronic kidney disease who are at risk for weak, low-turnover bone. It may help by changing how quickly your bones break down and rebuild.
AalborgAges 18–120 - NCT04523909Recruiting
Testing spinal fluid inflammation changes after aortic surgery
This study tracks inflammation-related lab markers in spinal fluid taken through a temporary drain during and after thoracic aortic surgery. It may help doctors understand what inflammatory changes happen around surgery and how they relate to recovery.
NijmegenAges 18 years+ - NCT04524247Recruiting
Testing a custom stent graft for frail aortic aneurysms
This study looks at a specialized, customized stent graft to treat certain aneurysms (bulges) of the aorta in people who may be considered frail. It’s meant to see how well the device works and how safely it can be used in patients who fit specific aneurysm patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT04524637Recruiting
Testing a clotting test in recent traumatic brain injury
This trial tests whether a special blood clotting test called thromboelastography can help assess clotting problems after a head injury. It may help doctors better understand bleeding risk and related complications early after trauma.
ShanghaiAges 18–80 - NCT04525144RecruitingPhase 2
Test EGb 761 for mild memory loss with brain blood vessel disease
This trial studies EGb 761 to see if it can improve symptoms in people with mild cognitive impairment (early memory/thinking changes) who also have signs of brain blood vessel disease. It may help by targeting the brain changes seen on scans.
SingaporeAges 45–85 - NCT04528082RecruitingPhase 3
Apremilast for children with frequent mouth ulcers from Behçet’s disease
This study tests apremilast to help reduce active, recurring mouth (oral) ulcers in children with Behçet’s disease. It may help if your child has had repeated mouth ulcers despite at least one non-biologic treatment.
BronAges 2–17 - NCT04529785Recruiting
Tested added ethanol vein treatment during repeat atrial fibrillation ablation
This trial compares two ways to help stop atrial fibrillation during a repeat procedure: standard vein isolation only versus standard isolation plus an added medicine (ethanol) into the vein of Marshall. It aims to see whether the added step improves results when atrial fibrillation returns after a previous successful treatment.
Bruges, Please SelectAges 18 years+ - NCT04532489RecruitingEarly Phase 1
PET scan study using a cholesterol-tracking tracer in healthy adults
This early study tests how well a special PET scan tracer can show cholesterol movement in the body. It is for healthy adults who do not have known adrenal problems, and it aims to collect basic imaging safety and dose information.
Ann Arbor, MichiganAges 18 years+ - NCT04533152Recruiting
Study risk factors for healing in diabetic foot ulcers
This study looks at what factors affect outcomes in adults with diabetic foot ulcers. It may help doctors better predict healing and complications by better understanding what influences progress.
CaenAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.