Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT05449834RecruitingPhase 3
Testing early fibrinogen treatment after serious trauma bleeding
This Phase 3 study tests whether giving fibrinogen early can improve outcomes for adults with serious trauma who are actively bleeding. The goal is to help blood clotting work better sooner and potentially reduce complications from uncontrolled bleeding.
Newcastle, New South WalesAges 18–100 - NCT05450328RecruitingPhase 2
Breathing medicine to help heart-lung machine separation after surgery
This Phase 2 trial tests whether inhaled medicines (milrinone and epoprostenol) can make it easier to separate from the heart-lung machine during cardiac surgery. It may help reduce the risk of a difficult transition off the machine for the right patients.
Montreal, QuebecAges 18 years+ - NCT05450783Recruiting
PET-MRI imaging study for arrhythmogenic heart disease
This study uses a special whole-heart scan (PET combined with MRI) to better understand the tissue and metabolism patterns in people with arrhythmogenic cardiomyopathy. The goal is to see whether these scan patterns relate to symptoms now and how the disease may change over time.
AngersAges 16–99 - NCT05452356Recruiting
Testing a phone-based care plan for people with heart conditions
This trial tests a phone app that helps deliver organized “care plans” for people with cardiovascular (heart/vessel) conditions. You might join to see if this phone-based support improves how care is delivered and helps you manage your condition.
London, OntarioAges 18 years+ - NCT05452889RecruitingEarly Phase 1
PET scan study in pulmonary hypertension related to scleroderma
This early study uses a PET scan (a type of imaging test) to better understand lung blood-vessel disease in people who have pulmonary hypertension related to scleroderma. It may help researchers find how imaging signals relate to disease and risk.
Pittsburgh, PennsylvaniaAges 18–75 - NCT05452720Recruiting
Testing a new pulmonary valve replacement in children
This study tests an early, first-use version of a new pulmonary valve device for children whose own valve is not working well. It may help improve blood flow from the heart to the lungs and aims to learn how safe and effective the valve is over time.
Peoria, IllinoisAges birth–22 years - NCT05453877Recruiting
Brain scan and health data study using a long-term cohort
This study uses existing health records and then collects or uses brain imaging (CT or MRI) along with basic health measurements. It may help researchers learn patterns in brain images that relate to health or disease risk in people from the Kailuan group.
Beijing, Beijing MunicipalityAges 18–90 - NCT05454267Recruiting
Study early blood vessel changes from vaping
This study looks for early signs of blood vessel problems in people who vape and in healthy non-vapers. It may help researchers find ways to detect and prevent vaping-related vascular disease early.
Miami, FloridaAges 18–40 - NCT05455489Recruiting
MitraClip registry for severe mitral valve leakage patients
This registry study collects information on people with severe mitral valve leakage (regurgitation) who are treated with the MitraClip G4 device. It aims to better understand which patients benefit most and how well the procedure works in real-world care.
San Donato Milanese, MilanoAges 18 years+ - NCT05455515Recruiting
Shockwave IVL study for calcified heart artery blockages
This registry studies how a device called Shockwave IVL (intravascular lithotripsy) is used to treat hard, calcified blockages in heart arteries when a stent is needed. It mainly helps doctors track outcomes and safety over follow-up.
FlorenceAges 18 years+ - NCT05457738Recruiting
Home walking program using a smartphone app for leg artery pain
This trial tests whether a home-based walking (exercise) plan, guided by a new smartphone app, can help people with intermittent claudication caused by blocked leg arteries. It may help improve walking comfort and ability by using a structured, app-supported exercise routine.
ReimsAges 18 years+ - NCT05459233Recruiting
Testing ultrasound-guided valve settings after valve-in-valve TAVR
This trial compares two ways to check and fine-tune how well a new valve is working after a “valve-in-valve” TAVR procedure. It looks to see whether measurements from ultrasound of the heart (Doppler echocardiography) match results from a catheter test, which could help guide safer, more accurate valve care.
San Francisco, CaliforniaAges 18 years+ - NCT05460416RecruitingPhase 3
Aspirin prevention in early pregnancy after frozen embryo transfer
This trial tests whether taking baby-dose aspirin after a frozen embryo transfer can lower the chance of developing pre-eclampsia, a blood-pressure problem that can happen during pregnancy. It targets women considered at higher risk based on specific health factors and pregnancy details.
LiègeAges 18–43 - NCT05460793Recruiting
Surgery timing trial for brain bleeding after a stroke
This trial looks at whether starting brain surgery within 8 hours after a type of stroke called intracerebral hemorrhage (bleeding in the brain) can improve outcomes. It’s for adults with a certain amount and location of bleeding and without common causes like an aneurysm or malformation.
AmsterdamAges 18 years+ - NCT05461729Recruiting
Testing a heart rehab timing prediction tool after a heart attack
This study follows people with coronary artery disease who are starting a structured heart rehabilitation program after a heart attack or heart procedures. The trial tests whether it can predict and improve the right timing or planning for cardiac rehab.
Ennepetal, North Rhine-WestphaliaAges 18 years+ - NCT05464186Recruiting
Whole versus nonfat milk effects on kids’ body composition
This study compares whole milk vs nonfat milk to see how each affects body composition (such as fat and lean mass) in children. It may help families understand whether milk type makes a difference for healthy growth.
Boston, MassachusettsAges 9–12 - NCT05465031RecruitingPhase 4
Testing heart-protection medicine during breast cancer treatment
This trial tests sacubitril/valsartan to help prevent heart weakness (cardiotoxicity) caused by breast cancer treatments like anthracyclines and/or anti-HER2 drugs. If you qualify, you may be offered this heart-protection medicine while your cancer is treated.
Opole, Opole VoivodeshipAges 18 years+ - NCT05465070Recruiting
Heat therapy trial for leg blood-flow problems
This trial studies whether applying heat to your legs can improve symptoms and function in people with peripheral artery disease (reduced blood flow to the legs). You may be tested with a simple blood-flow check and an MRI scan, depending on eligibility.
Indianapolis, IndianaAges 50 years+ - NCT05465200Recruiting
Study for cardiogenic shock treatment in adults under 24 hours
This trial is testing a treatment approach for adults with cardiogenic shock, a life-threatening condition where the heart can’t pump enough blood. You may be considered if your shock started within the last 24 hours and you meet other safety criteria.
WroclawAges 18–60 - NCT05466825Recruiting
Using health data to study cardiovascular risk
This study brings together existing health information to understand how common heart-risk factors relate to heart outcomes. It may help improve how future risk is predicted and prevented, especially in people who have not yet had heart disease.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT05468580Recruiting
Release or sham surgery for clogged celiac artery
This trial studies whether a surgical “release” of the celiac artery (to improve blood flow) helps people with MALS who have specific symptoms and artery narrowing. Some people will have a sham (placebo) procedure to compare outcomes, so you’ll be closely monitored either way.
Enschede, OverijsselAges 18 years+ - NCT05469165RecruitingPhase 2
Testing serotonin blockers after a first heart attack
This Phase 2 trial tests whether blocking serotonin receptors can help after a first heart attack that has caused a specific type of leaking mitral valve problem. It aims to see if the treatment improves heart function and heart-valve measurements while keeping patients safe.
QuébecAges 18–80 - NCT05469893RecruitingPhase 2
Targeted treatment for high-risk smoldering myeloma
This trial studies a precision approach to treat people with high-risk smoldering myeloma (a condition that can turn into active myeloma). The goal is to see whether the treatment can slow or prevent progression and improve outcomes.
Denver, ColoradoAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.