Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05534607Recruiting
Community hula program for dementia risk in older Native Hawaiians
This study tests whether joining a community hula (dance) program can help people reduce future dementia risk. It focuses on older Native Hawaiian or Pacific Islander adults who already have mild memory concerns and certain health conditions like high blood pressure or diabetes.
Honolulu, HawaiiAges 50–75 - NCT05537467Recruiting
Music during exercise for people with heart failure
This trial tests whether listening to music while you exercise can improve how well you can exercise when you have heart failure. It is mainly looking for adults who can safely do an exercise test and communicate in English.
Lexington, KentuckyAges 18 years+ - NCT05537753Recruiting
PFO closure device test after recent unexplained stroke
This trial tests whether closing a hole in the heart (a PFO) with a special device can help prevent another stroke after an unexplained stroke. You may be a candidate if your stroke likely happened because blood can pass through this PFO.
Little Rock, ArkansasAges 18–60 - NCT05539040Recruiting
Testing why certain heart signals trigger atrial fibrillation
This trial studies abnormal electrical signals in the right upper heart chamber and how they relate to atrial fibrillation (AF). It may help improve how doctors target AF treatment during catheter ablation for people who have AF symptoms.
LondonAges 18–85 - NCT05539859Recruiting
Brain bleed surgery trial using endoscope for deep brain bleeding
This trial tests whether a minimally invasive brain surgery using an endoscope can improve outcomes for people with a deep brain bleed. It also studies the safety of this approach compared with standard care.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT05539781Recruiting
Blood flow and brain function monitoring after carotid procedure
This trial studies how blood flow and brain function change after a carotid artery revascularization procedure (opening a narrowed carotid artery). It may help doctors understand what to expect after treatment, especially in people with significant artery narrowing.
Beijing, Beijing MunicipalityAges 18–85 - NCT05540561Recruiting
Testing and monitoring for nitrous oxide use
This study looks at how nitrous oxide (also called laughing gas) is detected and how health effects may show up over time. It may help doctors better diagnose problems early and track changes after use.
BéthuneAges 14–65 - NCT05544019RecruitingPhase 1
Testing an investigational drug for mature B-cell cancers
This early (Phase 1) study tests SGR-1505, an experimental treatment, in people with certain mature B-cell cancers. It’s mainly designed to see how the drug works in the body and to check safety, and it may offer an option if standard treatments aren’t enough.
Gilbert, ArizonaAges 18 years+ - NCT05543447Recruiting
Safety and effectiveness of a brain blood-vessel device for aneurysms
This study tests how safe and effective the DERIVO 2heal device is for treating an intracranial (brain) aneurysm. You may be a candidate if you’re an adult with an aneurysm that doctors plan to treat with this specific device and you can safely take anti-platelet medicines.
AugsburgAges 18 years+ - NCT05543798Recruiting
MRI-guided heart procedure for dangerous abnormal rhythms
This trial studies a heart rhythm procedure (“ablation”) for people with ischemic cardiomyopathy who have ongoing episodes of sustained ventricular tachycardia. It aims to reduce these dangerous rhythm events, especially when standard anti-rhythm medications don’t work or can’t be used.
Leipzig, SaxonyAges 18 years+ - NCT05544864Recruiting
Stent or balloon treatment guided by heart scar pattern
This study looks at how to treat blocked heart arteries that have narrowed again after a prior drug-eluting stent. It compares using another drug-eluting stent versus a drug-coated balloon, chosen based on an imaging scan inside the artery (OCT), to reduce repeat narrowing.
Frankfurt am Main, HesseAges 18 years+ - NCT05545605Recruiting
Sodium oligomannate to prevent thinking problems after stroke
This trial tests whether sodium oligomannate can help prevent or lessen memory and thinking problems that can happen after a first stroke. It may help people who are recently hospitalized for ischemic stroke and have mild cognitive decline risk.
Guangzhou, BaiyunAges 18–80 - NCT05545176Recruiting
Testing rules for stopping resuscitation after out-of-hospital arrests
This trial studies and checks decision rules doctors can use to decide when to stop CPR in patients who have an out-of-hospital cardiac arrest. It may help make those decisions more consistent and safer across Asian countries.
TaipeiAges 18 years+ - NCT05545865Recruiting
Test how grape-based drinks affect blood flow response
This study tests whether a grape product (“Chardonnay Marc”) can change how your blood vessels respond to stress, measured with a finger sensor. It may help researchers understand how diet influences circulation in people with a low baseline blood-flow response.
Davis, CaliforniaAges 30–50 - NCT05546099RecruitingPhase 3
Patient-guided blood pressure control in chronic kidney disease
This Phase 3 study tests whether a patient-driven plan for managing blood pressure can better control hypertension in people with chronic kidney disease (CKD). The goal is to see if this approach is safe and helps prevent health problems related to high blood pressure.
Iowa City, IowaAges 18 years+ - NCT05546723RecruitingPhase 1
Study drug for multiple myeloma after several prior treatments
This Phase 1 trial tests LMY-920 in people with multiple myeloma that has returned or stopped responding after multiple standard therapies. It’s meant to see if the treatment can work and to better understand its safety and side effects in this situation.
Cleveland, OhioAges 18 years+ - NCT05546931Recruiting
Mobile health program to help control high blood pressure
This study tests a phone-based (mobile) health program to help people in rural areas better control high blood pressure. It may help you track your readings and follow a plan that supports safer blood pressure over time.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05547165Recruiting
Closing a leaky heart connection early in very small babies
This trial compares an early procedure to close a heart vessel called the ductus arteriosus versus careful observation alone in very low-birth-weight preterm infants. It aims to see whether closing the vessel early can improve outcomes and be done safely.
Birmingham, AlabamaAges 1 week–1 month - NCT05547607Recruiting
Study of heart valve infection signs on heart scans
This study looks at clinical symptoms and test findings to better understand heart valve infection (endocarditis) in adults. It may help doctors recognize the condition sooner and interpret echocardiography results more accurately.
Cona, FerraraAges 18 years+ - NCT05548530Recruiting
Comparing outcomes after brain bleeding from different causes
This study looks at people with bleeding inside the brain to see how different treatment choices are linked to recovery. It may help doctors choose the most effective approach for patients with similar bleeding patterns.
Guiyang, GuizhouAges 18–80 - NCT05548413Recruiting
Helping heart failure patients take meds with family support
This study tests whether family-focused coaching and easy-to-read materials can improve heart failure medication adherence. It also uses an electronic pillbox to track how consistently you take your meds, with your care partner involved.
Lexington, KentuckyAges 18 years+ - NCT05549752RecruitingPhase 3
Flecainide vs amiodarone to treat fast heart rhythm in ER
This trial compares two medicines—flecainide and amiodarone—to help restore normal rhythm during an emergency visit for paroxysmal atrial fibrillation (a-fib). It’s aimed at people who also have coronary artery disease but no ongoing (residual) heart ischemia, and who have enough heart pumping strength.
AthensAges 18–85 - NCT05550077Recruiting
Imaging study for narrowed brain arteries after stroke
This trial uses a detailed eye/brain imaging test (optical coherence tomography) to study people with significantly narrowed brain arteries after certain stroke-like events. It may help researchers better understand and monitor this condition to improve care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05550324Recruiting
Pediatric heart disease patient data repository
This trial is a data repository that collects information from children with heart (cardiovascular) conditions and related syndromes. It focuses on organizing cases and comparing groups to help researchers better understand pediatric heart disease.
Columbus, OhioAges Any age
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.