Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,976 recruiting studies in this area right now.
By phase
- Not applicable7,959
- Phase 2483
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke841
- Heart Failure567
- Hypertension401
- Cardiovascular Diseases390
- Coronary Artery Disease372
- Multiple Myeloma334
- Atrial Fibrillation268
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California460
- Alabama197
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,973 total
- NCT07397650RecruitingPhase 4
Early finerenone for heart failure in hospital
This trial tests if starting finerenone early helps patients hospitalized with heart failure who have symptoms like shortness of breath or swelling. It aims to see if the drug is safe and effective when given soon after admission.
Handa, Aichi-kenAges 18 years+ - NCT06526858Recruiting
Laparoscopic kidney nerve treatment for resistant hypertension
This study tests a new treatment called HyperQure RDN, a laparoscopic (keyhole) surgery that targets nerves near the kidneys to lower blood pressure in people with resistant hypertension. If you have tried multiple medications but your blood pressure is still high, this procedure might offer an alternative approach.
Orange, CaliforniaAges 22–80 - NCT07747441Recruiting
Blood flow monitoring during day-case knee surgery
This study looks at how blood flow in your fingers relates to low blood pressure during knee surgery. It may help doctors better manage anesthesia for future patients.
Ankara, Yenimahalle\AnkaraAges 18–65 - NCT07665307Recruiting
Delayed side effects after CAR-T for multiple myeloma
This study looks at late side effects that may happen after CAR-T therapy (cilta-cel) for multiple myeloma. It aims to better understand these delayed toxicities so doctors can manage them more effectively.
San Francisco, CaliforniaAges 18 years+ - NCT07646444Recruiting
Study of OPN Balloon for Opening Hardened Heart Vessel Blockages
This is a follow-up study of patients who have already had a heart procedure using a special balloon (OPN balloon) to open calcified (hardened) blockages in heart arteries. Researchers will review records to see how well this balloon works and how patients recover.
Minneapolis, MinnesotaAges 18 years+ - NCT06113354Recruiting
Testing the MRace implant for leaky heart valve repair
This trial tests a new device called MRace that may fix a leaky mitral valve without open-heart surgery. It's for people whose valve leaks severely and who can't have standard surgery due to other health issues.
São Paulo, São PauloAges 18 years+ - NCT07275697RecruitingPhase 4
Weight loss drug and heart ablation study for AFib
This trial tests whether a weight loss medication (semaglutide) given before and after a first-time heart ablation procedure for atrial fibrillation can improve outcomes. It is for people who are overweight or obese and have certain related health conditions.
StockholmAges 18 years+ - NCT05001750RecruitingPhase 1
Preventing EVD infections with antibiotics before device placement
This early-stage study tests whether giving preventive (prophylactic) antibiotics helps prevent infections when an external brain fluid drain (EVD) is placed and used. It may help lower the chance of serious infections around the drain.
The Bronx, New YorkAges 18 years+ - NCT05511285Recruiting
Improving sleep and learning after arm stroke rehab
This study tests a sleep-improvement program (Sleepio) to see if better sleep can help people learn and recover after a stroke that affects the arm. You may be able to join if you’re recently out of hospital and can use the internet reliably.
OxfordAges 18 years+ - NCT05839652RecruitingPhase 4
Treatment for blood pressure drops after spinal cord injury
This Phase 4 trial studies a treatment to help people with spinal cord injuries who get orthostatic hypotension, meaning blood pressure drops when they change position. If you fit the specific injury and health criteria, the study may offer a structured way to improve symptoms and monitor safety.
West Orange, New JerseyAges 18–60 - NCT06787066RecruitingEarly Phase 1
Blood vessel study during menopause
This study looks at how blood vessels react to nerve signals during menopause. It may help explain why heart health changes after menopause.
Columbia, MissouriAges 18–70 - NCT06759818Enrolling by invitation
Vagus nerve stimulation for heart protection after lung surgery in older adults
This trial tests if a gentle ear stimulation device can protect the heart after lung surgery in patients aged 60 and older. It is for those having a planned lung procedure (lobectomy, segmentectomy, or wedge resection) through small chest incisions.
Jiaxing, ZhejiangAges 60 years+ - NCT06735378Recruiting
Exercise before dialysis to protect the heart
This study tests if doing gentle exercise just before dialysis can help prevent heart damage that sometimes happens during treatment. You may be able to join if you are on long-term dialysis and have not been exercising vigorously.
London, OntarioAges 18–79 - NCT06676085Recruiting
New ECMO blood-thinning strategy with nafamostat
This study tests a new way to manage blood-thinning medicine during ECMO (a machine that helps your heart and lungs). The goal is to see if using a drug called nafamostat in the ECMO circuit along with lower doses of a standard blood thinner can reduce side effects like bleeding.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06673862Enrolling by invitation
Detecting fluid needs with a breathing machine change
This trial checks if a simple change in ventilator settings (a tidal volume challenge) can predict whether you need more fluids, compared to a standard fluid challenge. It's for patients on a breathing machine who have low blood flow.
Banhā, Al-QalyubiaAges 18 years+ - NCT06469073Recruiting
Nerve block for pain after heart valve surgery
This study tests a special nerve block (ultrasound-guided) to see if it can better control pain after heart valve replacement surgery. It may help you recover more comfortably if you are having your first mitral or aortic valve replacement.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06430697Recruiting
Paracetamol's effect on blood pressure in ICU patients
This trial measures how a common painkiller, paracetamol, affects blood pressure in intensive care patients. If you are in the ICU and your doctor has ordered paracetamol, this study may help understand its hemodynamic effects.
NiceAges 18 years+ - NCT05606536Recruiting
Test whether IV fluid rate affects small blood flow
This study looks at whether changing how fast IV fluids are given during certain surgeries affects the body’s smallest blood vessels. You may be able to join if your surgery is planned and you meet safety limits.
Hradec KrálovéAges 18 years+ - NCT05565495RecruitingPhase 2
Hydromorphone dosing changes during ECMO
This Phase 2 study looks at how hydromorphone (a strong pain medicine) behaves in the body for people on ECMO, and how that may affect dosing. It may help doctors better choose the right pain-med dose while someone is receiving ECMO.
Wuhan, HubeiAges 18–80 - NCT05496751Recruiting
Exercise study for people with low activity habits
This study looks at how much your body’s response to exercise can vary over time. They’re enrolling people who are usually sedentary and whose weight and BMI fit their targets, to better understand exercise effects.
Kingston, OntarioAges 25–65 - NCT05462301Recruiting
Setting normal heart ultrasound ranges for newborns
This study measures echocardiogram (heart ultrasound) results in healthy newborn babies to help define “normal” ranges. It’s mainly for babies without serious heart or lung problems, and it can help improve how doctors interpret future newborn echocardiograms.
Chongqing, Chongqing MunicipalityAges 1 day–4 weeks - NCT04854278Recruiting
Operating room computer tool to reduce blood vessel procedure errors
This trial tests a new “black box” monitoring system in the operating room to spot mistakes and help prevent them during planned blood vessel procedures. It may improve safety by learning from real procedure events and error patterns.
Ghent, Oost-VlaanderenAges 18 years+ - NCT04852406Recruiting
Care plan study for people on blood thinners having abdominal surgery
This study looks at whether a structured (protocol-based) care plan before and around surgery improves outcomes for people taking blood-thinning medicines. It may help teams plan safer timing and monitoring to reduce complications around the operation.
Beijing, Beijing MunicipalityAges Any age - NCT03957928Recruiting
Mango pulp study for hunger and heart-health markers
This study tests whether eating fresh mango pulp can make you feel fuller (less hungry) and improve “heart-health” measurements. It may help people who are interested in diet changes, especially those with higher body weight and related health risks.
San Diego, CaliforniaAges 18–55
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,976 recruiting cardiology studies from the U.S. registry right now, out of 15,179 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.