Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 10,073 recruiting studies in this area right now.
By phase
- Not applicable8,041
- Phase 2490
- Phase 4483
- Phase 3452
- Phase 1359
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke855
- Heart Failure565
- Hypertension403
- Cardiovascular Diseases389
- Coronary Artery Disease375
- Multiple Myeloma330
- Atrial Fibrillation273
- Ischemic Stroke200
- Atrial Fibrillation (AF)146
- Acute Ischemic Stroke141
- Pulmonary Hypertension104
- Myocardial Infarction98
- Congenital Heart Disease87
- Peripheral Arterial Disease85
- Stroke, Ischemic84
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis78
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris92
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital54
- Massachusetts General Hospital51
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Insel Gruppe AG, University Hospital Bern50
- Johns Hopkins University47
Where studies are running
- California467
- Alabama198
- Massachusetts181
- Arizona176
- New York166
- Florida146
- Maryland120
- Texas120
- Illinois119
- Minnesota119
Recruiting studies10,070 total
- NCT05997914Enrolling by invitation
Storytelling to reduce stroke risk in African Americans with atrial fibrillation
This study tests whether a storytelling program can help African American patients with atrial fibrillation start taking blood thinners as recommended by their doctor. The goal is to reduce stroke risk and improve health outcomes.
Jacksonville, FloridaAges 18 years+ - NCT05979870Enrolling by invitation
AI-enhanced heart MRI for valve disease
This study uses artificial intelligence to improve MRI scans for people with aortic or pulmonary valve disease who are scheduled for valve surgery or a non-surgical valve procedure. It aims to help doctors better assess heart function before treatment.
Gothenburg, GothenburgAges 1 week–18 years - NCT05971433Enrolling by invitation
Studying how body stress signals affect sleep and heart health
This study looks at how “stress signals” in the body after an injury may affect sleep and cardiovascular (heart and blood vessel) health. It may help researchers understand what contributes to recovery and how to improve outcomes for wounded service members.
Bethesda, MarylandAges 18 years+ - NCT05967728Enrolling by invitationPhase 2
Testing remote arm conditioning to protect the brain in stroke
This Phase 2 study tests whether a simple remote method that briefly reduces blood flow in the arm (called ischemic conditioning) can help people with brain small-vessel disease or an acute ischemic stroke. Participants are monitored by phone and, for stroke patients, through a Mobile Stroke Unit.
Calgary, AlbertaAges 55 years+ - NCT05952999Enrolling by invitation
Studying Hospital-At-Home care done from home
This trial looks at how well a “Hospital at Home” program works when people start from the emergency department or are already in the hospital and can be cared for at home. It may help teams improve care at home for certain medical conditions and situations.
Peoria, IllinoisAges 18 years+ - NCT05942859Enrolling by invitation
AI study using heart ECGs to spot pulmonary hypertension
This study looks at patterns on a 12-lead ECG (a common heart tracing) to help diagnose pulmonary hypertension, using results from a right heart catheter test. It may help doctors use ECGs better in the future, without changing your current care.
BathAges 18 years+ - NCT05927090Enrolling by invitation
Repair outcomes after acute aortic dissection surgery
This study looks at how patients do after surgery for an urgent (acute) tear of the aorta or related bleeding in the wall of the ascending aorta. It may help doctors better understand what outcomes to expect after early emergency surgery.
Saint-DenisAges 18–90 - NCT05915260Enrolling by invitation
Heart MRI study in adults with type 2 diabetes
This study uses a heart scan (MRI) to learn more about how the heart is affected in people with type 2 diabetes. It may help researchers better understand changes in the heart over time and who might benefit from future care.
SlagelseAges 18–80 - NCT05913999Enrolling by invitation
PET and heart scans during early chemotherapy
This trial studies how a specialized heart imaging test (PET/MPI) changes during the start of chemotherapy for cancer patients. It may help researchers understand whether this monitoring approach detects heart strain early and keeps patients safer during treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT05912634Enrolling by invitation
Repair versus not repair of aortic arch in dissection
This trial compares two surgical approaches for a dangerous tear/dissection of the aorta in the upper chest area. It looks at whether repairing the aortic arch (the curved part of the main blood vessel) improves outcomes compared with not repairing it.
Saint-Denis, FranceAges 18–90 - NCT05912608Enrolling by invitation
Best way to repair certain urgent aortic tears
This study looks at the best surgical strategy for repairing an acute (sudden) tear of the ascending aorta. It may help doctors choose the safest and most effective repair method for people who need urgent surgery soon after symptoms begin.
Saint-DenisAges 18–90 - NCT05889806Enrolling by invitation
Study uses blood and tissue samples for gene and protein testing
This study collects and analyzes your donated samples (like blood or other biospecimens) to look for patterns in genes and proteins. The results may help researchers understand disease biology and improve future tests or treatments.
New Orleans, LouisianaAges 18 years+ - NCT05889416Enrolling by invitation
Testing a new cardiac rehabilitation program for heart attack patients
This study checks how well a “perfect” version of cardiac rehabilitation (CR) works for people who had a type 1 heart attack. It may help improve follow-up care and outcomes by making CR delivery more consistent.
MalmöAges 18–79 - NCT05835596Enrolling by invitation
App-based support to protect heart health after pregnancy
This trial tests whether a smartphone app (“MumCare”) can help improve or support cardiovascular (heart and blood vessel) health in people after certain pregnancy complications. It’s for new or recent moms who had pregnancy-related high blood pressure and/or gestational diabetes.
Oslo, OsloAges 18–50 - NCT05830422Enrolling by invitation
Predicting late thinking problems after cardiac arrest
This study looks at how to predict delayed cognitive (thinking) impairment in people who survived a cardiac arrest but initially seemed neurologically okay. It may help identify who is at higher risk so follow-up and support can be planned earlier.
Daejeon, Seo-guAges 18 years+ - NCT05825898Enrolling by invitation
Treatment outcomes for severe leaking tricuspid valve
This study looks at what happens to adults with moderate-to-severe or severe tricuspid valve “leaking” after different treatment types, such as catheter-based or surgery. It may help doctors understand which approach works best for people with severe valve leakage and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT05809713Enrolling by invitation
Heart to Heart program to better control high blood pressure
This trial tests a “Heart to Heart” program using regular check-ins (including cell-based monitoring) to help lower high blood pressure. It’s for adults who have had blood pressure that stays too high even with usual care.
Greenville, North CarolinaAges 19 years+ - NCT05800743Enrolling by invitation
Stent grafts for high-risk ascending aorta problems
This study tests a new stent graft placed through the groin/back to treat problems in the ascending aorta (and sometimes the arch), usually when open-heart surgery is considered too risky. Doctors will check whether the device is safe and works well over time, including imaging and a long follow-up.
Birmingham, AlabamaAges 18 years+ - NCT05794165Enrolling by invitationPhase 2
Antithrombin to prevent blood clots after serious trauma
This Phase 2 trial studies whether giving antithrombin can better prevent harmful blood clots (venous thromboembolism) after serious injuries. The goal is to reduce clot risk while you’re in the trauma ICU or step-down unit.
Aurora, ColoradoAges 18 years+ - NCT05775354Enrolling by invitation
Early heart disease check-in in adults age 50–80
This study aims to improve early detection of heart and blood vessel problems by adding further research after routine care. It may help you by making sure your heart risk is monitored more closely, if you’re eligible and agree to the additional steps.
UtrechtAges 50–80 - NCT05775224Enrolling by invitation
Join a research data hub for sickle cell or multiple myeloma
This study builds a database of people with sickle cell disease and/or active multiple myeloma (diagnosed or treated in recent years). It may help researchers learn how these illnesses behave and support better future studies or treatments.
Washington D.C., District of ColumbiaAges Any age - NCT05768386Enrolling by invitation
Long-term follow-up for severe hemophilia A after BMN 270 study
This study checks how people with severe hemophilia A are doing over time after joining a previous BioMarin study of BMN 270. It helps researchers understand long-term safety and outcomes and may support your ongoing care plan.
Los Angeles, CaliforniaAges 18 years+ - NCT05758467Enrolling by invitation
Study linking adult oral health, social factors, and heart health
This study looks at how people’s oral health in adulthood relates to social factors and heart health. To join, you must have already taken part in specific past health surveys.
BergenAges 71–72 - NCT05727852Enrolling by invitation
Breath and heart tests to study lung disease stiffness
This study uses breath analysis and heart/electrical heart testing to look at how stiff the arteries are in people with long-term lung conditions. It may help researchers better understand lung disease effects on the cardiovascular system.
MoscowAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 10,073 recruiting cardiology studies from the U.S. registry right now, out of 15,588 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.