Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT06804161RecruitingPhase 3
Testing SGLT2 Inhibitors for Heart Health in Hypertension
This trial tests whether an SGLT2 inhibitor (a type of diabetes drug) can help prevent heart attacks, strokes, and other heart problems in people with high blood pressure. You may be eligible if you are 60 or older, have high blood pressure, and have had a heart or blood vessel event (like a heart attack or stroke) or have certain risk factors (like smoking, high cholesterol, or obesity).
Lübeck, Schleswig-HolsteinAges 60 years+ - NCT07165340Enrolling by invitationPhase 1/Phase 2
Physiotherapy for leg swelling from vein disease
This study tests whether adding a special physiotherapy program can help reduce leg swelling in people with vein disease. If you have swelling from varicose veins or other vein problems and have not tried certain treatments before, you may be able to join.
Houston, TexasAges 18 years+ - NCT07151989Enrolling by invitation
How valve disease type affects new valve durability
This study looks at people who had their mitral valve replaced to see if the original valve problem (tight vs leaky) affects how long the new valve lasts. It may help doctors understand which patients need closer follow-up.
Maastricht, MaastrichtAges 18 years+ - NCT07150559Recruiting
Arch-clamping under mild cooling for acute aortic dissection
This trial tests a surgical technique called arch-clamping under mild hypothermia (cooling the body slightly during surgery) to treat acute type A aortic dissection. It may help patients who need immediate total aortic arch replacement.
Beijing, Beijing MunicipalityAges 18–70 - NCT07145515Recruiting
Heart preservation device trial for transplant patients
This trial tests a portable device that keeps donor hearts healthy outside the body before transplant. It may help more donor hearts be used, including those from donors after circulatory death and hearts previously considered less suitable.
San Francisco, CaliforniaAges 18 years+ - NCT07270887Recruiting
Can gentle arm cuffs protect your heart and brain over time?
This trial tests if using a blood pressure cuff on your arm in short cycles can help prevent future heart attacks, strokes, and other problems in people at very high risk. You may qualify if you've already had a major heart or blood vessel event.
ShenyangAges 40 years+ - NCT07382700Enrolling by invitation
Blood markers in heart attack patients treated with stents
This study looks at certain fats in the blood of people having a severe heart attack called STEMI. Researchers want to see if these fats can help understand what happens in the body during a heart attack.
Ningbo, ZhejiangAges 50–70 - NCT06554925Recruiting
Sex differences in cardiac surgery patients
This study looks at how men and women may differ in their experiences and outcomes after heart surgery. It may help doctors provide better care for all patients.
Amsterdam, North HollandAges 18 years+ - NCT05796739Recruiting
Stress testing once or only when needed for high calcium risk
This study compares two approaches to stress testing in people who feel fine but have high coronary artery calcium on a scan. It may help determine whether testing routinely is better than doing it only if symptoms or concerns arise.
SeoulAges 19 years+ - NCT06060912Recruiting
Comparing two heart devices to prevent stroke in atrial fibrillation
This study compares two devices (LAmbre and AMPLATZER Amulet) that are placed in the heart to prevent strokes in people with atrial fibrillation who cannot take blood thinners. If you join, you will be randomly assigned to get one of the two devices.
Munich, BavariaAges 18–100 - NCT07275931Recruiting
Digital support program for heart failure patients
Researchers in Sweden are testing a digital support program to help patients with heart failure manage their condition at home. If you qualify, you'll use a smartphone or computer-based program that may offer tips, tracking, and help from a care team.
Linköping, Östergötland CountyAges 18 years+ - NCT06394739Recruiting
RevCore for blood clots in leg stents
This trial tests a special catheter to remove blood clots that have formed inside a leg vein stent. It may be an option for people who have had a stent in place for more than 6 weeks and have a new clot in certain leg veins.
New Haven, ConnecticutAges 18 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Chicago, IllinoisAges 18 years+ - NCT05715697Recruiting
Kidney artery treatment for heart failure with normal heart pumping
This study tests whether renal denervation (a procedure to reduce overactive signals in kidney arteries) can help people who have heart failure but keep a normal pumping ability and still have high blood pressure. It aims to improve blood-pressure control and heart function in this specific group.
Ürümqi, XinjiangAges 21–80 - NCT07326605Enrolling by invitation
Heart MRI study for heart failure with preserved pumping function
This trial uses a special heart MRI to create pressure-volume loops in people with heart failure who have a normal pumping strength (ejection fraction of 50% or higher). It aims to better understand heart function and could help guide future treatments. You may qualify if you have heart failure symptoms and specific heart structure or function changes.
Ages 18 years+ - NCT07106788Recruiting
Study of Aveir leadless pacemaker in Japan
This trial is for people who already have an Aveir leadless pacemaker and either were in a previous study or need to upgrade from a single-chamber to a dual-chamber system. It helps monitor the device's performance in real-world use.
Nagoya, Aichi-kenAges Any age - NCT07278869Recruiting
Study of Append system for atrial fibrillation patients
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Jonesboro, ArkansasAges 18 years+ - NCT06855407Recruiting
Blood pressure and brain blood flow during anesthesia study
This study looks at how blood pressure medicines affect blood flow to the brain during general anesthesia for planned surgery. It may help doctors understand how to better manage care during operations.
UmeåAges 50–80 - NCT07198789Recruiting
Low-sugar carbs for better fat and sugar levels
This study tests whether special carbohydrates that release sugar slowly (low glycemic index) can improve your blood fats (triglycerides) and other health markers better than regular whole grains. If you have moderately high triglycerides, this diet swap might help your metabolism and blood vessels.
Bologna, BOAges 18 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT06859047Recruiting
Comparing heart ultrasound to invasive testing
This study compares results from an invasive heart test (hemodynamic assessment) with a non-invasive ultrasound (echocardiogram) done on the same day. It aims to see if the ultrasound can provide similar information, potentially reducing the need for invasive procedures.
BariAges 18 years+ - NCT06386718Recruiting
Ultrasound of hand arteries in children
This study uses ultrasound to look at the blood vessels in the hands of children before they have surgery. It helps doctors understand hand blood flow better, which can make procedures safer.
AnkaraAges Up to 10 years - NCT05805111Recruiting
BeGraft stents for blocked aorta and iliac arteries
This trial tests a specific stent system (BeGraft) to improve blood flow through the aorta and iliac arteries in people with symptomatic peripheral artery disease. It may help reduce symptoms and improve leg circulation, based on the study device’s ability to fit your artery anatomy.
BerlinAges 18–99 - NCT07081243Recruiting
A study on a procedure for hard-to-treat high blood pressure
This study looks at a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can drive high blood pressure. It is for people whose blood pressure stays high even with several medications, or who cannot tolerate blood pressure pills.
Shanghai, Shanghai MunicipalityAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.