Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06101303Recruiting
Endometriosis pain study using surgery and surveys
This study looks at pain in people with or without endometriosis who are having laparoscopic surgery. Researchers want to understand more about pelvic pain by collecting information before, during, and after surgery.
St Louis, MissouriAges 12–45 - NCT06083896RecruitingPhase 1
Pelvic bone cancer treatment with light-activated nails
This trial tests a new way to treat cancer that has spread to the pelvic bone. It uses a special nail that is activated by light to help stabilize the bone and reduce pain, while also improving your ability to move around after surgery.
Houston, TexasAges 18 years+ - NCT05366140Recruiting
Implanet Jazz spine fusion for adults needing thoracolumbar stabilization
This trial looks at using the Implanet Jazz system during spine fusion surgery for adults who need stabilization in the middle-to-lower back. It may help patients by improving how well the fused spine heals and stays in place.
Lexington, KentuckyAges 18–100 - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years - NCT05868330RecruitingPhase 4
Compare two nerve-block methods for shoulder replacement
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
Iowa City, IowaAges 18–90 - NCT06058624Recruiting
Digital pain management program for veterans
This study tests a new digital program that helps veterans with long-term pain learn to accept and cope with it. You would use a computer at home to complete the program and share your feedback.
West Haven, ConnecticutAges 18 years+ - NCT06077422Enrolling by invitationPhase 2/Phase 3
Comparing two pain blocks for heart surgery recovery
This trial compares two types of pain blocks (Exparel vs. Marcaine) given during heart surgery to see which one provides better pain relief. If you are scheduled for a heart surgery through a small or full chest incision, you may be able to join.
New Brunswick, New JerseyAges 18 years+ - NCT06066853RecruitingEarly Phase 1
MDMA plus therapy for fibromyalgia pain
This trial tests whether MDMA (a drug sometimes called 'ecstasy') can help people with fibromyalgia when used alongside therapy sessions. The goal is to see if it reduces pain and improves quality of life.
Charlestown, MassachusettsAges 21–65 - NCT06077227Recruiting
Virtual reality for phantom limb pain
This study tests whether virtual reality therapy can help reduce phantom limb pain or uncomfortable sensations after amputation. If you have a major limb amputation and feel pain or other sensations in the missing limb, this might be an option to try.
Charlotte, North CarolinaAges 18 years+ - NCT06059586Recruiting
Pre-hab program for women getting pelvic radiation for cancer
This trial tests a pre-rehabilitation (pre-hab) program to help women stay stronger before and during pelvic radiation for certain cancers. The goal is to see if it improves quality of life and reduces treatment side effects.
Avon, IndianaAges 18 years+ - NCT06080464Recruiting
Doctor satisfaction with VERABAND™ for chronic low back pain
This study tests how satisfied doctors are with a wearable device called VERABAND™ that monitors movement in people with chronic low back pain. If your pain limits your ability to move, you may be able to help researchers understand if this device is useful during your regular non-surgical treatment.
La Jolla, CaliforniaAges 18–85 - NCT06063902Enrolling by invitation
Long-term opioid therapy for chronic pain
This study looks at the risks and benefits of long-term use of opioids (strong painkillers) for chronic pain that is not caused by cancer. It aims to help doctors and patients make better decisions about pain management.
UppsalaAges 18 years+ - NCT06065449RecruitingPhase 3
Comparing two radiation therapies for painful bone metastases
This trial compares two types of radiation therapy to relieve pain from cancer that has spread to the bones. It aims to see whether a more targeted, high-dose approach (SBRT) works better than standard palliative radiation.
Houston, TexasAges 18 years+ - NCT06081101RecruitingEarly Phase 1
Comparing two injections for sacroiliac joint pain
This trial compares two types of pain-relieving injections for sacroiliac joint pain. One is a common anti-inflammatory (ketorolac), and the other is a steroid. The goal is to see which works better and lasts longer.
Hamilton, OntarioAges 18 years+ - NCT06058169Recruiting
Home vibration therapy for arthritis knee pain
This study tests if doing whole-body vibration exercises at home can help reduce knee pain from arthritis. You stand on a gently vibrating platform for short periods over several weeks.
Augusta, GeorgiaAges 40–75 - NCT06070662Recruiting
New MRI test for small heart vessel disease
This study tests a new way to diagnose small blood vessel disease in the heart using an MRI scan during a stress test. It is for people who are already participating in a larger heart imaging study and are scheduled for a catheter procedure.
Leicester, LeicestershireAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT04219956Recruiting
Low-sugar diet aims to reduce belly-surgery pain
This study tests whether a special diet low in polyamines (a food-related substance) can reduce pain after major abdominal surgery. It compares pain control while you use a patient-controlled morphine pump or take opioid tablets by mouth after surgery.
BrestAges 18 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT06054802Enrolling by invitation
Sleep and pain after spine surgery in teens
This study looks at how sleep quality before and after spine surgery affects pain recovery. It uses text messages to check in with participants, so a mobile device is needed.
Columbus, OhioAges 10–18 - NCT06042621Enrolling by invitation
Improving communication in the ICU for patients, families, and staff
This study looks at how doctors, nurses, and other healthcare team members talk with patients and their families in the intensive care unit (ICU). It aims to improve understanding and support for everyone involved.
Chicago, IllinoisAges 18 years+ - NCT06041321Recruiting
Testing a new sleeve for knee surgery recovery
This trial tests a special sleeve designed to help reduce pain and improve recovery after knee surgery for a torn meniscus. It may be a good option if you are having this type of knee surgery and are in generally good health.
Woodbury, New YorkAges 18–89 - NCT06045936RecruitingPhase 4
Nerve block for phantom limb pain
This study tests whether a nerve block in the remaining part of your leg can help reduce phantom limb pain or pain in the residual limb. It is for people who have had an amputation more than a year ago and still have pain despite trying other treatments.
Mankato, MinnesotaAges 18 years+ - NCT06013878Recruiting
Testing a tool for caregivers who help with transfers
This study tests a special instrument to measure how caregivers help people with physical disabilities move from one place to another (transfers). It may help improve safety and technique for both caregivers and care recipients.
Pittsburgh, PennsylvaniaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.