Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT03674255Enrolling by invitation
Tests how accurate heart ultrasound is during stress
This study checks how well a heart ultrasound (echocardiography) works when your heart is at rest and under stress. You may benefit by getting closer attention to how the test is done, especially if it’s being used to look for blocked-heart-blood-flow problems.
Ages 18 years+ - NCT03584815Recruiting
Test of physiotherapy versus surgery for exercise leg muscle pressure
This trial compares a physiotherapy program to a surgical procedure (fasciotomy) for chronic “compartment” pressure in the lower leg triggered by exercise. If you have symptoms that reliably come on with walking/running and improve with rest, the study may offer a structured way to find the best treatment for you.
Copenhagen, CopehagenAges 18–50 - NCT03695887RecruitingEarly Phase 1
Disposable nitrous oxide for pain during burn dressing changes
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
Winnipeg, ManitobaAges 18 years+ - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT03715517Recruiting
Spinal anesthesia to improve recovery after liver surgery
This trial studies whether using spinal/epidural anesthesia during liver tumor removal surgery can help people recover better and with less pain. It compares this approach to standard general anesthesia care to see if recovery is smoother.
Winnipeg, ManitobaAges 18 years+ - NCT03661645Enrolling by invitationPhase 4
Steroid dose taper after orthopedic surgery
This trial tests whether a planned, gradually stopping steroid medicine (methylprednisolone) after certain orthopedic surgeries helps with recovery or symptoms. It compares a post-surgery steroid taper to other routine care and focuses on safety and outcomes after surgery.
Atlanta, GeorgiaAges 18–95 - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT03415620Recruiting
Music listening during surgery to reduce anxiety and pain
This study tests whether listening to music around the time of surgery can lower anxiety and pain, reduce how much pain medicine you need, and improve satisfaction. You may be asked to fill out brief questionnaires before and after your procedure.
SingaporeAges 21–70 - NCT03446456RecruitingPhase 1/Phase 2
Vasopressin and pain perception study
This trial tests whether vasopressin, a nasal spray, changes how your brain processes pain. You will receive either the spray or a placebo and have an MRI scan to see brain activity.
Baltimore, MarylandAges 18–65 - NCT03434392Recruiting
Testing pain-sensing to predict treatment response in chronic pancreatitis
This study uses a special pain-testing method to better predict how people with chronic pancreatitis-related pain (or similar conditions) will respond to treatment. It may help doctors choose therapies that work better for each person’s type of pain.
Baltimore, MarylandAges 18 years+ - NCT03353584Recruiting
Virtual reality for pain relief during sickle cell pain crises
This trial tests whether a virtual reality (VR) experience can help reduce pain during a sickle cell “vaso-occlusive crisis,” which is an episode of sudden, severe pain. It’s offered alongside the care team’s usual pain management to see if VR makes pain feel better.
Memphis, TennesseeAges 6–25 - NCT03304730Recruiting
Tracking pain patterns after low back joint injections
This study follows adults with long-lasting low back pain to learn what predicts who improves after a specific type of back joint injection. It mainly helps doctors understand which factors relate to better or worse outcomes over time.
São Paulo, São PauloAges 18 years+ - NCT03258580Recruiting
Studying how culture and mind affect how we feel pain
This study looks at how beliefs, mood, and social factors affect how people express and judge pain. It mainly uses pain/heat testing and—if chosen—brain scans to understand why pain reports can differ between people.
Bethesda, MarylandAges 18–60 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT02707029Recruiting
Study of how people report pain and painful conditions
This study looks at how accurately people can describe their pain and related symptoms. It may help researchers improve how pain is measured in future studies.
Bethesda, MarylandAges 12–120 - NCT02991625Enrolling by invitation
Brain scan study to find markers for chronic back pain
This study uses brain imaging (MRI scans) to look for “biomarkers” (measurable signs) that may relate to chronic low back pain. It compares people with long-lasting back pain to healthy volunteers to understand what brain patterns are linked to pain.
Halifax, Nova ScotiaAges 18–75 - NCT02845531RecruitingPhase 4
Defibrillator device vs medicines for a rare heart spasm after arrest
This trial compares an implantable defibrillator device plus best care versus best medicines alone in people who survived a cardiac arrest caused by a specific abnormal heart rhythm. It focuses on variant angina, where a heart-spasm problem can trigger dangerous rhythm events, to see which approach prevents future events.
Bucheon-siAges 18 years+ - NCT02446262Recruiting
Study of how the brain and mind shape pain in healthy adults
This study tests how people sense heat and pain, and how the brain and emotions may influence that experience. It is designed for healthy adults and may involve training sessions and (for some parts) MRI scanning.
Bethesda, MarylandAges 18–50 - NCT02352116Recruiting
Pain treatment plan after outpatient surgery for young children
This study tests a pain-management plan right after surgery for children ages 1–6 who go home the same day. It aims to see whether the plan improves comfort after anesthesia without requiring longer hospital recovery.
New York, New YorkAges 1–6 - NCT02521311RecruitingPhase 2
Clemastine to help restore nerve covering in optic neuritis
This Phase 2 trial tests whether clemastine can help regrow the protective covering around the optic nerve after acute optic neuritis (an inflammation-related vision problem). It may help improve vision recovery and signal how well “remyelination” happens.
San Francisco, CaliforniaAges 18–55 - NCT01550575Recruiting
Study of outcomes in people treated with Boston Scientific devices
This study looks back at what happened to patients after treatment (or if they could have used) Boston Scientific medical devices. It may help improve how these devices are used and understand real-world results.
Lake Havasu City, ArizonaAges 18 years+ - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Phoenix, ArizonaAges 18 years+ - NCT02038127Recruiting
Heart procedure outcomes tracking registry
This study collects information from people having a heart procedure called percutaneous coronary intervention, or PCI, to learn more about their outcomes and improve future care.
Chuncheon, Gangwon-doAges Any age
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.