Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07061223Enrolling by invitation
Comparing two nerve block methods for hip replacement surgery
This trial tests two types of nerve blocks (SFIB and PENG) to find which provides better anesthesia during total hip replacement. It may help you understand which pain control approach could work best for your surgery.
MoscowAges 50–75 - NCT06903182Recruiting
Timing of TAP block for gallbladder surgery
This study compares giving a nerve block (TAP block) before or after gallbladder removal surgery to see which reduces pain better and improves recovery.
Padua, ItalyAges 18 years+ - NCT03926403Recruiting
Hypnosis support for anxiety during face surgery
This trial looks at whether guided hypnosis can improve how people feel about having face surgery performed with numbing medicine (local anesthesia). If you’re experiencing significant anxiety beforehand, hypnosis support may help you feel more comfortable during your outpatient procedure.
AmiensAges 18 years+ - NCT06929000Recruiting
Testing an adjustable headrest for painless abortion in overweight patients
This study tests whether a special adjustable headrest can help make painless abortion surgery safer and more comfortable for people who are overweight or obese. You may be able to join if you are planning this procedure, have a BMI over 24, and are otherwise healthy enough for anesthesia.
Wuhan, HubeiAges 20–50 - NCT06669494Enrolling by invitation
Study on ICU muscle weakness detection and monitoring
This study aims to find better ways to detect and track muscle weakness that can happen during an ICU stay. If you or your loved one is in the ICU, this research could help improve early diagnosis and care.
Seoul, SeoulAges 18 years+ - NCT06927193Recruiting
Pain relief for kids in the emergency room
This trial looks back at how well nerve blocks work for children who received them in the emergency department. If your child had a nerve block during an ER visit from 2023 to 2025, this study may include their experience.
HaderaAges Up to 18 years - NCT07258537Enrolling by invitation
Comparing two hand therapies for sacroiliac joint pain
This study compares two types of hands-on therapy (a gentle side-lying adjustment vs. a lower back roll) to see which works better for long-lasting low back pain caused by the sacroiliac joint. If you have ongoing pain and are open to physical treatments, this trial may help find the best approach.
Gujrat, Punjab ProvinceAges Any age - NCT07053176Enrolling by invitationPhase 4
Neck injection for dizziness linked to neck pain
This trial tests whether a local anesthetic injection in the neck (paravertebral lidocaine) can reduce dizziness that is related to neck pain or stiffness. It may help if your dizziness started along with neck pain, trauma, or limited movement.
Fara in Sabina, RietiAges 18–80 - NCT07737912Enrolling by invitation
SpinePal app for spine fusion recovery
This study tests a smartphone app called SpinePal along with a wrist fitness tracker to help you recover after spine fusion surgery. If you qualify, you'll use the app and tracker for a few months to see if they improve your recovery and reduce pain.
Lebanon, New HampshireAges 18 years+ - NCT07222787Recruiting
Testing a new spinal implant for lower back fusion
This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.
Scottsdale, ArizonaAges 18–80 - NCT07248514Recruiting
Pilates for kids with backpack-related back pain
This study tests if Pilates exercises can help children aged 12-16 who have back pain and poor posture from carrying heavy backpacks.
Lahore, Punjab ProvinceAges 12–16 - NCT06826690RecruitingPhase 4
Comparing pain medicine mixes for hand surgery wrist blocks
This trial tests different combinations of numbing medicines injected around the wrist before hand surgery. The goal is to find which mix provides the best pain relief with fewer side effects.
Aswān, Aswan GovernorateAges 18 years+ - NCT06575179RecruitingPhase 4
Testing a sedative to reduce anesthesia needs during gallbladder surgery
This trial tests if a sedative called dexmedetomidine can lower the amount of anesthetic (sevoflurane) needed to block body responses during keyhole gallbladder surgery. If it works, it may make anesthesia safer for patients.
Fuzhou, FujianAges 18–45 - NCT07239687Recruiting
Comparing two propofol sedation methods for ICU patients on ventilators
This study compares two computer-controlled methods for delivering propofol sedation to ICU patients on a breathing machine. It aims to determine which method provides safer and more effective sedation for critically ill patients.
AnkaraAges 18 years+ - NCT07472010Recruiting
Jaw Stretching with Slow Breathing for Calmness
This study tests whether doing a simple jaw-stretching exercise along with a slow breathing pattern (breathe in for 4 seconds, hold for 4, breathe out for 8) can help calm your body's 'fight or flight' system. It is designed for healthy students who want to try relaxation techniques.
Konya, KonyaAges 18–30 - NCT07036237Enrolling by invitation
Comparing pain relief rinses after root canal
This trial tests whether rinsing the tooth with either tramadol (a pain reliever) or dexamethasone (a steroid) after a root canal reduces pain better. It is for people with a single-rooted tooth that has a very painful, inflamed nerve.
Karachi, SindhAges 18–50 - NCT07382063Enrolling by invitation
Nerve block effects on diaphragm in kids having arm surgery
This study tests a special numbing shot (nerve block) around the shoulder to see how it affects the muscle that helps kids breathe (the diaphragm) during and after arm surgery. It may help doctors choose safer pain methods for school-aged children.
ShanghaiAges 6–12 - NCT07329426Recruiting
Muscle energy therapy with mobilization for sacral torsion
This trial tests if combining muscle energy therapy with spinal mobilization can relieve pain and correct misalignment in people with a twisted pelvic bone (sacral torsion). It may help reduce pain and improve mobility.
Islamabad, Punjab ProvinceAges 22–44 - NCT05563038Recruiting
Scrambler therapy for pain after stroke
This trial studies whether “scrambler therapy” can reduce ongoing pain in the body areas affected by a past stroke. It may help people who are at least a month past stroke and still have stroke-related pain.
Baltimore, MarylandAges 18 years+ - NCT06456073RecruitingPhase 1
Cell therapy for chronic anal fissures
This trial tests a new treatment made from special cells (called E-CEL UVEC) for people with long-lasting anal fissures that haven't healed with standard treatments. The goal is to see if this cell-based therapy can reduce pain and help the fissure heal.
New York, New YorkAges 18 years+ - NCT06526572Recruiting
Pain measurement with brain waves in tooth infection
This trial tests a new way to measure pain from a tooth infection using brain wave recordings (EEG). It may help people whose numbing injection doesn't work well.
Cleveland, OhioAges 18–50 - NCT07231419RecruitingPhase 3
Study of suzetrigine for diabetic nerve pain
This trial tests an experimental pain drug called suzetrigine for people with diabetic peripheral neuropathy (nerve damage from diabetes that causes pain in the feet and legs). It aims to see if the drug can safely reduce pain over time.
Birmingham, AlabamaAges 18–80 - NCT06599255Enrolling by invitation
Pain relief after gallbladder surgery: one shot vs. multiple shots
This trial compares two ways of giving a numbing injection (nerve block) to ease pain after laparoscopic gallbladder removal. One method uses a single injection, the other uses several smaller injections. The goal is to see which provides better pain control with fewer side effects.
Zagazig, Elsharkia,, Egypt,Ages 18–45 - NCT06597097Enrolling by invitation
Study of healthcare team collaboration with medical cannabis
This study looks at how healthcare professionals work together – between primary care doctors, hospital doctors, and pharmacists – during France’s medical cannabis experiment. It aims to see if teamwork improves care.
BrestAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.