Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07573969RecruitingPhase 3
Pain Relief Medicines Added to Spinal Injection for Back Surgery
This trial tests whether adding one of two different medicines (dexmedetomidine or ketamine) to a numbing injection in the lower spine improves pain relief after back surgery. You would receive the injection while asleep during surgery to help manage pain afterward.
CairoAges 21–60 - NCT07576296Recruiting
Shoulder exercises for rounded shoulders after pregnancy
This study tests whether specific shoulder blade exercises and stretches can help new mothers with rounded shoulders and shoulder discomfort. It aims to improve posture and reduce pain during the postpartum period.
Lahore, Punjab ProvinceAges 20–35 - NCT06728371RecruitingPhase 3
IV methadone for pain after heart surgery
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
Hong KongAges 18 years+ - NCT06535633Recruiting
Exercise program for older adults with chronic pain
This study looks at whether a community exercise program can help older adults with long-term muscle or joint pain. It is designed for people who are not already active and want to try a gentle, guided exercise program.
LimerickAges 50 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06506565RecruitingPhase 4
Low-dose ketamine for burn wound pain
This trial tests a low-dose ketamine infusion during burn wound dressing changes to see if it reduces pain. It might help people who are hospitalized with a thermal burn injury.
Memphis, TennesseeAges 18 years+ - NCT07565844Recruiting
Injected treatments for nerve pain after shingles
This trial tests three injected treatments—tiny cell particles, platelet-rich plasma, and steroids—directly into the skin to reduce long-lasting nerve pain that follows shingles. If you've had persistent shingles pain for at least 3 months, this study may help ease your discomfort.
Zagazig, ZagazigAges 18 years+ - NCT07564167Recruiting
Dextrose Injection for Tailbone Pain Relief
This study tests whether injecting dextrose (a sugar solution) under ultrasound guidance can relieve chronic tailbone pain that hasn't improved with standard treatments like physical therapy or medication. The injection is designed to stimulate healing in the painful area.
IstanbulAges 18–75 - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT07561203Recruiting
Collavant supplement for runner's knee discomfort
This study tests whether Collavant®, a collagen-based supplement, reduces knee pain in amateur runners aged 40–65 who experience discomfort during or after training. You'll take the supplement for 24 weeks while continuing to run and track your symptoms.
Madrid, MadridAges 40–65 - NCT07561489Enrolling by invitation
Study of OsteoPearl Implants for Spine Fractures
This study observes how a biological implant called OsteoPearl helps people recover from recent spine fractures in the mid or lower back. Researchers will track your pain relief and ability to function over time after a minimally invasive procedure to stabilize the fracture.
Williamsville, New YorkAges 50 years+ - NCT06732765Recruiting
Eloda with or without muscle energy for back pain relief
This trial tests whether adding a muscle relaxation technique to Eloda treatment helps people with lower back pain caused by a tight muscle near the hip. It aims to find a more effective way to reduce pain and improve movement.
Sialkot, Punjab ProvinceAges 18–45 - NCT06731985Recruiting
Shorter sling tape follow-up study
This study looks at how well and how safely a shorter type of sling tape (used to treat stress urinary incontinence) works over time. It may help women who had this specific surgery between 2009 and 2020 understand their long-term results.
LorenskogAges 25–90 - NCT06731920Recruiting
Ultrasound guided neck injection study
This study is testing a new way to guide a neck injection (called a cervical medial branch block) using ultrasound. It may help doctors do the procedure more safely and accurately.
Kelowna, British ColumbiaAges 19 years+ - NCT05275881Recruiting
Virtual reality during procedures for young blood or cancer patients
This trial tests whether using virtual reality (VR) during certain procedures can make them easier for children, teens, and young adults with blood or cancer-related conditions. Participants must be able to safely use a VR headset and be willing to take part.
PoitiersAges 7–24 - NCT06191159Recruiting
Comparing scar looks after different mastectomy incision methods
This trial compares three different ways surgeons make the incision (cut) during a mastectomy to see which one leads to the best-looking scar. You may be eligible if you are having a mastectomy without immediate reconstruction.
Vancouver, British ColumbiaAges Any age - NCT07566663Recruiting
Pain Relief Before Gallbladder Removal Surgery
This study tests whether a pain-relief medication called Anrikefon, given before laparoscopic gallbladder removal surgery, helps reduce pain after the procedure. Laparoscopic surgery uses small cuts and a camera, so it's less invasive than open surgery.
Beijing, Beijing MunicipalityAges 18–65 - NCT07563998Recruiting
Fast heart attack blood test in the ambulance
This study tests whether a quick blood test done by paramedics in the ambulance can safely rule out a heart attack in patients with chest pain or similar symptoms. The goal is to help patients get faster, more accurate care before reaching the hospital.
Aarhus NAges 18 years+ - NCT07562048Recruiting
Comfort Cuddling for Children in Critical Care
This study looks at whether gentle cuddling and physical comfort help children feel better while they're in the intensive care unit. Researchers believe close contact with caregivers may reduce stress and improve how children recover.
Calgary, AlbertaAges Up to 18 years - NCT07566871Enrolling by invitation
Nerve Stimulation to Help Burn Injury Recovery
This study tests whether gentle electrical stimulation of a nerve in your ear can help reduce anxiety, improve sleep, and ease pain or itching after a burn injury heals. You would wear a small device on your ear for several weeks.
Istanbul, KartalAges 18–65 - NCT07561333Recruiting
Pain Relief Methods for Knee Replacement Surgery
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
Çorum, CentreAges 18–80 - NCT07559890Recruiting
Nerve ablation for low back pain with Modic changes
This study tests a procedure that uses heat to stop a nerve in the lower back from sending pain signals. It may help people with long-term central low back pain who have not gotten better with other treatments and have Modic changes on MRI.
PragueAges 18 years+ - NCT07562412Recruiting
Audio Mindfulness for Quick Pain Relief
This study tests whether listening to brief guided mindfulness audio recordings can help reduce acute (sudden, short-term) pain. Researchers will see how different amounts of listening affect pain levels.
Tallahassee, FloridaAges 18 years+ - NCT07567300Recruiting
Understanding Pain Patterns in Migraine and Neck or Back Pain
This study explores how migraine headaches, neck pain, and lower back pain may share similar pain mechanisms in the body. Researchers will ask you questions to understand your pain patterns and help identify connections between these conditions.
Gaziantep, MerkezAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.