Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07217964Enrolling by invitation
Study of natural protein for spinal fusion surgery
This trial is testing a natural protein material used during spinal fusion surgery to treat lower back pain caused by worn-out discs. It may help patients who haven't gotten better with other treatments and need surgery on up to four levels of the lower spine.
New York, New YorkAges 18 years+ - NCT07217457Enrolling by invitation
Comparing two methods for placing a chest-area epidural
This study compares two ways of placing a thoracic epidural (a thin tube that delivers pain medicine near your chest) during surgery: one uses a pressure wave in the needle, and the other uses live X-ray images. It will help see which method is more accurate and easier.
Lebanon, New HampshireAges 18 years+ - NCT07215845Recruiting
Healing spinal bone stress with MRI monitoring
This study uses MRI scans to see how well a spinal stress injury (called a pars defect) heals over time. It might help if you are a young person with low back pain from a specific type of bone stress in the lower spine.
Columbia, MissouriAges 12–30 - NCT07213622Enrolling by invitation
Smart glasses for numbing nerve block during knee replacement
This study tests if using smart glasses (like high-tech glasses that show a video) can help doctors give a more accurate numbing injection (nerve block) to the saphenous nerve for knee replacement surgery. The goal is to improve pain control after surgery.
Cleveland, OhioAges 18 years+ - NCT06848166RecruitingEarly Phase 1
Middle meningeal artery embolization for resistant chronic migraine
This study tests a procedure called 'middle meningeal artery embolization' using a special glue-like material (SQUID) to treat chronic migraine that hasn't responded to other treatments. The goal is to see if blocking blood flow to the membrane around the brain can reduce migraine attacks.
Bishkek, BishkekAges 35–59 - NCT07211464Recruiting
ACT plus exercise for older adults with chronic low back pain
This study tests whether combining acceptance and commitment therapy (ACT) with exercise helps older adults manage ongoing low back pain. If you've had pain for at least 3 months and it's been bothering you, this approach might teach you new ways to cope and move better.
Hong KongAges 60 years+ - NCT07706244Recruiting
Does reducing pre-surgery anxiety help orthopedic patients recover better?
This study tests if a program to reduce anxiety before surgery (Enhanced Recovery After Surgery) improves how patients feel one year after major orthopedic surgery like knee, hip, or spine procedures, compared to standard care.
Hualien City, Hualien CountyAges 20–100 - NCT07210892Recruiting
Spinal anesthesia needle angles study
This study looks at the best angle for inserting the needle during spinal anesthesia. It may help doctors find a more comfortable and effective way to give the numbing medicine.
BarcelonaAges Any age - NCT07209514Enrolling by invitation
Testing a spinal cord stimulator for diabetic nerve pain in the legs
This trial is studying a device called the Medtronic Inceptiv™ Closed-Loop DTM Spinal Cord Stimulator to see if it can help reduce pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) in the lower legs. It is for people whose pain has lasted at least 6 months and hasn't been helped by other treatments.
Grand Island, NebraskaAges 19 years+ - NCT07209995Enrolling by invitation
Ultrasound-guided arm block for obese patients
This trial compares two types of ultrasound-guided nerve blocks for obese patients having surgery on or below the elbow. The goal is to find which approach works best for this group.
ZagazigAges 21–45 - NCT06820073Recruiting
Stretching study for office workers with neck or back pain
This study tests if a gentle stretching method using a special hammock can help reduce neck and back discomfort for people who sit at work. It's looking for volunteers who have some aches but no serious diagnoses.
Zaragoza, ZaragozaAges 18–65 - NCT07208630Recruiting
Mobilization therapy for seniors' movement and thinking
This trial tests a hands-on therapy called instrument-assisted soft tissue mobilization to see if it improves how well you move and think. It may help seniors who struggle with balance or memory.
GizaAges 65–75 - NCT06534866Recruiting
Kinesio tape plus therapy for plantar fasciitis
This study tests whether adding kinesio tape (a stretchy therapeutic tape) to standard physical therapy can reduce heel pain, improve ankle motion, and help you walk better. It is for people with plantar fasciitis who haven't had recent injections or surgery.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT07405398Recruiting
Smartwatch study to detect opioid use and withdrawal
This study uses a smartwatch to track wrist data and help detect when someone is using opioids or experiencing withdrawal. It's designed for people with opioid use disorder who are starting or already on treatment with methadone or buprenorphine.
Wilmington, North CarolinaAges 22 years+ - NCT06535633Recruiting
Exercise program for older adults with chronic pain
This study looks at whether a community exercise program can help older adults with long-term muscle or joint pain. It is designed for people who are not already active and want to try a gentle, guided exercise program.
LimerickAges 50 years+ - NCT06561672Enrolling by invitationEarly Phase 1
Pain relief study for day surgery patients
This study tests if a combination of paracetamol and tramadol works as well as fentanyl for preventing pain after day surgeries. The goal is to help patients recover faster with fewer side effects.
Zagazig, Sharqia ProvinceAges 21–65 - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT06859957RecruitingPhase 3
Melatonin for chronic low back pain
This trial tests if melatonin can help reduce chronic low back pain. If you have had low back pain for at least 3 months that limits your daily activities, this study might be for you.
RotterdamAges 18–65 - NCT06933381Recruiting
Cold spray for pain during Nexplanon insertion
This study tests whether a numbing cold spray (vapocoolant) can reduce pain during Nexplanon implant insertion. If you are getting a Nexplanon placed in your arm, you may be able to join.
Honolulu, HawaiiAges 14 years+ - NCT06915896Recruiting
Chronic back or neck pain: predicting therapy outcomes
This study looks at people with long-term low back or neck pain who are waiting for physical therapy. It aims to find what factors predict how well they will do with different treatment paths.
Florence, FIAges 18 years+ - NCT06541015Recruiting
TENS for improving walking after stroke
This study tests whether a small electrical device (TENS) can help stroke survivors walk better. You will receive TENS or placebo while walking on a treadmill, and the researchers will measure how your muscles respond.
Dallas, TexasAges 18–80 - NCT04763356Recruiting
Remote monitoring to manage nerve pain after chemotherapy
This study tests whether remote check-ins (via phone/app/website) can help manage chemotherapy-related nerve pain in the hands and feet. It enrolls adults who developed nerve symptoms after certain cancer medicines and need ongoing monitoring.
Salt Lake City, UtahAges 18 years+ - NCT07193836Enrolling by invitation
Lidocaine for easier recovery after laparoscopic surgery
This study tests whether giving lidocaine (a numbing medicine) through an IV can help you wake up more smoothly and with less discomfort after laparoscopic gallbladder or gynecologic surgery. If you are generally healthy and having one of these specific surgeries, you may be a good fit.
Yinchuan, NingxiaAges 18–70 - NCT06874452RecruitingPhase 4
Anti-anxiety pill for second cataract surgery
This study tests if giving the anti-anxiety pill alprazolam (XANAX) before your second cataract surgery helps reduce anxiety and improve satisfaction with the procedure.
TaipeiAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.