Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,497 recruiting studies in this area right now.
By phase
- Not applicable9,839
- Phase 2787
- Phase 1573
- Phase 3531
- Phase 4344
- Phase 1/Phase 2304
- Phase 2/Phase 3119
Top conditions
- Stroke856
- Parkinson Disease424
- Alzheimer Disease341
- Multiple Sclerosis341
- Dementia228
- Ischemic Stroke201
- Epilepsy196
- Insomnia156
- Obstructive Sleep Apnea155
- Traumatic Brain Injury154
- Spinal Cord Injuries151
- Sarcopenia149
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis107
Leading sponsors
- Beijing Tiantan Hospital135
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University71
- National Taiwan University Hospital69
- University of Minnesota63
Where studies are running
- California675
- Massachusetts305
- New York294
- Florida277
- Texas270
- Maryland245
- Alabama213
- Arizona211
- Illinois193
- Pennsylvania177
Recruiting studies12,495 total
- NCT02638701RecruitingPhase 1/Phase 2
Infliximab for hard-to-treat brain blood vessel aneurysms
This Phase 1/2 trial tests infliximab, a medicine that calms inflammation, for dolichoectactic aneurysms in the vertebral/basilar brain blood vessels that usually cannot be treated with standard surgery or procedures. The goal is to see if it can improve safety and how the aneurysm behaves over time.
San Francisco, CaliforniaAges 18 years+ - NCT02685969Recruiting
Brain scan study of amyloid and brain sugar use
This study uses brain imaging to measure two things in the brain—amyloid protein and how the brain uses sugar. It may help researchers better understand early brain changes in people in the ALFA project.
Barcelona, CataloniaAges 45–75 - NCT02673996Recruiting
Study of POTS body chemical signals and blood pressure control
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
Calgary, AlbertaAges 18–60 - NCT02793999Recruiting
Near-infrared monitoring to guide cooling in newborns
This study tests a special, non-invasive sensor (near-infrared light) to help doctors choose the best cooling treatment for some newborns after brain injury. It may improve how well cooling works and how safely it’s managed in the first week of life.
Boston, MassachusettsAges Up to 2 years - NCT02693223Recruiting
Get With the Guidelines Stroke Registry for people with recent stroke
This study collects health information from people who were recently treated for certain types of stroke or “TIA” (a warning stroke). It helps doctors understand care and improve future treatment, and you may be included if you were treated in the hospital for one of these conditions.
Dallas, TexasAges 18–125 - NCT02747303RecruitingPhase 2
Focused radiation for 1 to 5 brain metastases without surgery
This Phase 2 study tests a precise, no-head-frame radiation technique to treat brain metastases. It may help by aiming radiation tightly at the tumors while limiting exposure to nearby healthy brain.
Chicago, IllinoisAges 18 years+ - NCT02886247Recruiting
Personal or family history of pancreatic tumors registry study
This study is building a registry (a secure list) of people who have had pancreatic tumors or have close family members who have had them. Your information can help researchers learn more and plan future studies for pancreatic cancer.
Baltimore, MarylandAges 18 years+ - NCT02763683Recruiting
Study brain changes in Parkinson-related dementia
This study looks at brain features linked to dementia in people who have Parkinson disease. It may help researchers understand why dementia happens in Parkinson and how it could be detected or treated in the future.
St Louis, MissouriAges 50 years+ - NCT02800486RecruitingPhase 2
Targeted antibody plus repeat radiation for recurrent brain tumors
This trial studies giving cetuximab (a targeted antibody) directly into an artery along with repeat radiation to treat certain recurring or treatment-resistant brain tumors. It may help by delivering the drug more directly to tumor areas and testing whether this approach can control the disease after it comes back.
New York, New YorkAges 18 years+ - NCT02811653Recruiting
Brain movement and memory study in early dementia
This study looks at how “slower movement” and brain changes relate to memory and thinking problems in people with early dementia (and some related conditions). It may help researchers understand what brain differences go with these symptoms, using tests and an MRI scan.
AmiensAges 40–85 - NCT02824731Recruiting
Proton vs photon radiation for certain brain tumors
This study compares two types of radiation—protons and photons (X-rays)—for specific brain tumors or tumor returns. It aims to see which approach works best and is safest for you, based on how much and where the radiation is delivered.
DresdenAges 18 years+ - NCT02883335Recruiting
MS registry for people living in Lorraine
This study is a registry that collects information from people who have multiple sclerosis (MS). It helps researchers better understand MS in the Lorraine region and may guide future care.
NancyAges Any age - NCT02850588Recruiting
Track outcomes after carotid stent or surgery
This study follows people who need a procedure to treat narrowed carotid arteries, comparing results after either surgery (CEA) or a less invasive procedure (TCAR). It mainly looks at patient safety and outcomes, which can help improve future care.
Chicago, IllinoisAges 18 years+ - NCT02890641Recruiting
Study of brain signals and genes in hard-to-treat epilepsy
This study looks at genetic factors and brain electrical activity in children whose seizures are difficult to control with standard medicines. It also involves exams like MRI and possibly procedures under anesthesia, to better understand seizure causes and help future care.
ParisAges 3 months–25 years - NCT02861898RecruitingPhase 1/Phase 2
Cetuximab delivered into the brain tumor artery for new glioblastoma
This Phase 1/2 study tests whether giving cetuximab directly into the artery that feeds the brain tumor can help people with newly diagnosed glioblastoma. It aims to target the tumor more precisely while checking safety and early signs of benefit.
New York, New YorkAges 18 years+ - NCT02869048Recruiting
Study blood and immune signals in ALS and healthy controls
This trial studies the “innate immune system” (your body’s first-line immune response) in people with ALS and in comparison groups. It may help researchers understand what drives ALS and how immune changes could relate to symptoms.
AarhusAges 18 years+ - NCT02912897RecruitingPhase 1
EBV T-cell treatment for early multiple sclerosis-like symptoms
This early-phase study tests whether a patient’s own immune cells (made to target a common virus called EBV) are safe and practical for people who have their first episode that strongly suggests multiple sclerosis. If it works well, it could offer a new way to treat early disease—but the main goal now is safety and feasibility.
NantesAges 18–45 - NCT02915198RecruitingPhase 4
Metformin for prediabetes to reduce heart and blood-vessel events
This trial tests whether taking metformin in people with prediabetes can lower the chance of future heart attack, stroke, or other blood-vessel problems. You may be a good fit if you have prediabetes plus existing cardiovascular disease or significant blood-vessel disease.
Phoenix, ArizonaAges 18 years+ - NCT03094312Recruiting
Check how a seizure-brain procedure affects thinking after surgery
This study looks at whether a special brain-recording procedure for difficult-to-control seizures changes a person’s memory, thinking, or other brain skills afterward. It may help doctors understand risks and plan care for people undergoing the procedure.
BronAges 18–65 - NCT03004326Recruiting
Biopsy study to test skin inflammation gene signals
This study uses a skin biopsy to look at “gene signals” (transcriptomics) in patients with active vasculitis that shows up on the skin. It may help researchers understand what is happening in your disease and how different types of vasculitis differ.
Los Angeles, CaliforniaAges 5 years+ - NCT03207464RecruitingPhase 1/Phase 2
PET/MRI scan study for nerve inflammation in multiple sclerosis
This early-phase study uses a special PET scan and an MRI to look at nerve-related inflammation in people with multiple sclerosis (MS). The goal is to see whether this scan can detect MS-related changes, which could improve how MS is studied in the future.
Boston, MassachusettsAges 18–60 - NCT02919930Recruiting
Testing a new breathing support choice for central sleep apnea
This study looks at which settings to use for adaptive servo-ventilation (ASV), a machine that helps breathing during sleep. It is meant for people with central sleep apnea who are not getting enough benefit from CPAP, so ASV may be a better match.
LeuvenAges 18 years+ - NCT02920788Recruiting
Rehab program study for mild traumatic brain injury symptoms
This trial studies whether a specific rehabilitation program (“GOALS”) helps veterans with mild traumatic brain injury (TBI) who still have thinking or memory problems. It compares the program to usual care, using regular assessments and training over time.
San Francisco, CaliforniaAges 18 years+ - NCT03286335Recruiting
Proton radiation for slow-growing or benign brain tumors
This trial studies proton radiation therapy for adults with certain benign or slow-growing brain tumors. It aims to see how well tumors can be controlled, and how treatment affects quality of life and side effects.
Boston, MassachusettsAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,497 recruiting neurology studies from the U.S. registry right now, out of 19,911 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.