Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT03067467Recruiting
MRI scan study of brain tumors using special carbon imaging
This trial uses a special MRI scan that shows how “metabolism” (how cells use fuel) differs in brain tumors. It may help researchers better understand tumor biology and how tumors may respond to treatment, without using chemotherapy or radiation as part of the study.
Dallas, TexasAges 18–70 - NCT01694953Recruiting
Study of how MNGIE changes over time
This study follows people with MNGIE (a rare mitochondrial disease) to better understand what happens over time and how lab markers relate to health. It does not test a new drug as part of the study.
New York, New YorkAges 5 years+ - NCT07667985Recruiting
Cognitive Reserve and Recovery from Fatigue in Older Adults
This study looks at how life experiences and education (cognitive reserve) help older adults bounce back from mental fatigue. Researchers want to find out if higher cognitive reserve leads to faster recovery after tiredness, which could improve quality of life.
Uşak, UşakAges 65–90 - NCT06189963RecruitingPhase 1/Phase 2
Cell therapy trial for moderate Alzheimer's disease
This trial tests a new immune cell therapy (SNK01) for people with moderate Alzheimer's disease. The goal is to see if it can slow down memory and thinking decline.
Glendale, CaliforniaAges 40–85 - NCT06160492RecruitingPhase 3
Testing a Glowing Dye to Improve Brain Tumor Removal
This trial compares two surgical techniques for removing malignant brain tumors: one using a special dye (5-ALA) that makes tumor cells glow under a blue light, versus the standard white light surgery. The goal is to see if the dye-guided approach helps surgeons remove more of the tumor safely.
Guangzhou, GuangdongAges 18–70 - NCT03426579Recruiting
Testing sedation monitoring during anesthesia for children’s throat surgery
This trial looks at whether a monitoring method for how deeply a child is sedated matches how the child’s reflexes react during intravenous anesthesia. It may help anesthesiologists keep children safer and more comfortable during direct laryngoscopy procedures using medications like dexmedetomidine and remifentanil.
Edegem, AntwerpAges 1 month–8 years - NCT00670735Recruiting
Research registry collecting data on hydrocephalus treatment
This study collects information about people with hydrocephalus when they have certain brain fluid (CSF) procedures. The goal is to better understand different patient groups and treatments across multiple centers.
Birmingham, AlabamaAges Up to 18 years - NCT02509442Recruiting
Testing brain responses during awake brain surgery
This trial measures how the brain reacts to small electrical stimulation during an awake surgery for a specific type of brain tumor. It may help surgeons better plan and improve care for people having their first surgery for this tumor type.
MontpellierAges 30–50 - NCT02358187RecruitingPhase 2
Vaccine for children and teens with low-grade brain tumors
This trial tests a peptide vaccine plus a medication called poly-ICLC for people with certain low-grade gliomas that cannot be fully removed. The goal is to help the immune system recognize and attack the tumor.
Pittsburgh, PennsylvaniaAges 1–21 - NCT07120100Recruiting
TMS for nerve pain from cancer chemo in breast/gyne cancer survivors
This trial tests if transcranial magnetic stimulation (TMS), a noninvasive brain treatment, can reduce nerve pain caused by chemotherapy in women who have had breast or gynecologic cancer. You may be eligible if you have ongoing nerve pain that hasn't been helped by standard pain medications.
Salt Lake City, UtahAges 18 years+ - NCT02544100Recruiting
Study for newborns with brain or nervous system problems
This study enrolls newborns (within the first 28 days of life) who have specific brain or nervous system conditions. It tests how these conditions are tracked and studied, which may help improve care and understanding over time.
Shanghai, Shanghai MunicipalityAges Up to 4 weeks - NCT07109830Recruiting
Brain-computer game for thinking skills in kids
This study tests a brain-computer game that uses brain waves to measure thinking skills in kids ages 7-16 with or without movement challenges. The goal is to see if the game can help evaluate cognitive abilities in a fun way.
Edmonton, AlbertaAges 7–16 - NCT07166432Recruiting
New brain stimulation for thinking and balance problems in Cushing syndrome
This trial tests a new, minimally invasive brain stimulation technique for people with Cushing syndrome who have developed a condition called cerebellar cognitive affective syndrome (CCAS). It aims to improve both thinking skills and movement coordination.
BeijingAges 18–85 - NCT03705715RecruitingPhase 1
Study brain immune-cell activity in different mental and brain conditions
This Phase 1 study looks for patterns (correlates) in how “microglial” brain immune cells become activated across different neuropsychiatric conditions and in healthy volunteers. It uses brain imaging to help researchers understand what might drive symptoms and differences between people.
Houston, TexasAges 18–80 - NCT03179774Recruiting
Procedure trial for blocked carotid artery to improve brain blood flow
This trial studies an endovascular procedure to reopen a chronically blocked carotid artery and improve blood flow to the brain. It also compares outcomes against standard care in part of the study, for people who show abnormal brain circulation on brain scans.
TaipeiAges 20 years+ - NCT07108920Recruiting
Balance and Botox for Stiff Knee Gait
This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).
Héricourt, Nord Franche-ComtéAges 18 years+ - NCT05740683Recruiting
Studies alpha-synuclein and brain symptoms in smell loss
This study looks at whether a specific brain protein (alpha-synuclein) is linked to other neurologic symptoms in people who have long-lasting smell loss. It may help researchers understand what causes smell loss and how it relates to later brain or nerve changes.
CopenhagenAges 55–75 - NCT01406691RecruitingPhase 4
Light flashes for delayed sleep phase disorder
This trial tests whether timed light flashes can help people whose sleep schedule is consistently delayed (they fall asleep and wake up much later than desired). If you’re still in high school and your main issue is this delayed sleep pattern, you may be able to join.
Palo Alto, CaliforniaAges 15–19 - NCT06066775Recruiting
Glucose, fats, and brain health in aging
This study looks at how blood sugar and fat levels relate to brain aging over time. It may help understand why some people's brains age faster than others.
Jinan, ShandongAges 50 years+ - NCT02836158RecruitingPhase 2/Phase 3
Test drug plus spinal chemotherapy for older PCNSL
This trial studies whether adding R-IDARAM and medication delivered into the spinal fluid can improve treatment for primary central nervous system lymphoma (PCNSL) in newly diagnosed older adults. It may help by targeting lymphoma cells in the brain, covering membranes, and spinal fluid.
Beijing, Beijing MunicipalityAges 60–75 - NCT07179848RecruitingPhase 1
Temporal interference brain stimulation safety study in healthy adults
This trial tests a new type of non-invasive brain stimulation that uses a weak electrical field to gently influence brain activity. It is designed for healthy adults to see if the procedure is safe and comfortable, and to gather information that could help develop future treatments for mental health conditions.
TaipeiAges 20–65 - NCT07141420Enrolling by invitation
Smartphone tool to help ICU recovery
This study tests whether a smartphone tool can help people recover from the long-term effects of being in the ICU. You might be eligible if you had a recent ICU stay and are comfortable using a smartphone.
Guiyang, GuizhouAges 18–100 - NCT03684018RecruitingPhase 4
Testing two doses of Privigen for children with CIDP
This study tests whether two different dose levels of Privigen (a type of immune blood treatment) are safe and effective for children and teens with CIDP. It may help improve nerve-related symptoms in people whose CIDP has been confirmed or is being evaluated as likely.
Phoenix, ArizonaAges 2–17 - NCT03286686Recruiting
Study of thinking and hand skills after brain injury
This study looks at how people with an injury to the back part of the brain (posterior parietal cortex) process what they see and guide their movements. It may help researchers better understand the symptoms and improve future therapies.
BronAges 18–75
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.