Ophthalmology
Eyes & vision clinical trials
Eye disease and conditions that affect sight. We’re tracking 1,760 recruiting studies in this area right now.
By phase
- Not applicable1,199
- Phase 3133
- Phase 2119
- Phase 1117
- Phase 492
- Phase 1/Phase 286
- Phase 2/Phase 314
Top conditions
- Glaucoma107
- Myopia88
- Cataract76
- Diabetic Retinopathy51
- Dry Eye38
- Keratoconus34
- Retinitis Pigmentosa33
- Age-Related Macular Degeneration31
- Amblyopia26
- Eye Diseases24
- Graves Disease24
- Sjogren's Syndrome24
- Dry Eye Disease (DED)23
- Multiple Sclerosis22
- Astigmatism21
- Ocular Hypertension21
- Diabetic Macular Edema20
- Macular Degeneration20
Leading sponsors
- Zhongshan Ophthalmic Center, Sun Yat-sen University25
- Medical University of Vienna20
- Second Affiliated Hospital, Zhejiang University, School of Medicine19
- Fondation Ophtalmologique Adolphe de Rothschild18
- Assistance Publique - Hôpitaux de Paris16
- The Hong Kong Polytechnic University16
- Eye & ENT Hospital of Fudan University15
- National Eye Institute (NEI)15
- National Taiwan University Hospital15
- Shanghai Eye Disease Prevention and Treatment Center15
Where studies are running
- California133
- Arizona69
- Florida43
- Maryland39
- Texas37
- Massachusetts35
- New York35
- Alabama26
- North Carolina20
- Pennsylvania20
Recruiting studies1,760 total
- NCT04642729Enrolling by invitation
Fresh cornea lenticule implant for macular corneal dystrophy
This trial tests a new way to treat macular corneal dystrophy using a thin piece of clear cornea (a lenticule) from a donor. Instead of a full transplant, the surgeon uses a laser (RELEX SMILE) to insert this lenticule to improve vision.
PristinaAges 20–55 - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04634383Recruiting
Testing a brain-connected implant to help some blind people see
This early safety study tests an implanted device placed in the brain to help people with very limited sight (no or minimal light). It focuses on whether the implant can be safely used and whether it may support vision-related signals over time.
Chicago, IllinoisAges 19–70 - NCT04600570Recruiting
Ultrasound measurement of the eye nerve in adults
This study uses an ultrasound scan to measure the space around the optic nerve in healthy adults. It helps researchers better understand normal ultrasound measurements for comparison in future eye or brain-related conditions.
TaipeiAges 20 years+ - NCT04604834Recruiting
Platelet-rich plasma treatment for corneal nerve damage
This trial studies whether your own platelet-rich plasma can help heal a fragile, slow-to-recover cornea caused by reduced corneal feeling (nerve damage). It may help reduce corneal erosion and improve corneal surface healing.
Monterrey, Nuevo LeónAges 18 years+ - NCT04663750RecruitingPhase 3
Surgery to treat bleeding under the retina in wet macular degeneration
This trial tests whether a specific eye surgery plus targeted clot-busting medicine and gas can improve vision after bleeding under the retina from “wet” age-related macular degeneration. It aims to reduce how long the bleeding lasts and help protect the central vision.
BonnAges 50–120 - NCT04528355Recruiting
Study of hospital data after stem cell transplant for non-cancer illness
This study collects medical information from people with certain non-cancer conditions who receive a stem cell transplant. It may help doctors better understand transplant outcomes and care, since the study focuses on data collection rather than adding new treatment.
Pittsburgh, PennsylvaniaAges 2 months–60 years - NCT04591483Recruiting
Test study for ELOVL4-related Stargardt-like vision loss
This trial is for people with a specific genetic cause of Stargardt-like macular dystrophy due to ELOVL4 mutations. It uses regular eye tests and imaging to see how the condition is affected and whether the study approach might help.
Bethesda, MarylandAges 10–100 - NCT04528082RecruitingPhase 3
Apremilast for children with frequent mouth ulcers from Behçet’s disease
This study tests apremilast to help reduce active, recurring mouth (oral) ulcers in children with Behçet’s disease. It may help if your child has had repeated mouth ulcers despite at least one non-biologic treatment.
BronAges 2–17 - NCT04519619Recruiting
Safety study of aflibercept eye injections in Japanese glaucoma patients
This trial checks how safe aflibercept (eye injection) is for Japanese people with neovascular glaucoma. You may be able to join if you already received aflibercept treatment under the approved Japanese instructions and have the correct diagnosis.
Multiple LocationsAges Any age - NCT04553523Recruiting
Hydrus microstent study for open-angle glaucoma with cataracts
This study enrolls people who have cataracts and primary open-angle glaucoma that is being treated with eye drops. It will look at how well the Hydrus microstent works after approval, especially for lowering eye pressure safely.
Irvine, CaliforniaAges 45 years+ - NCT04505618Recruiting
Eye scan study using special imaging for blood-vessel disease
This study uses a detailed eye scan (optical coherence tomography angiography) to look at how blood vessels in the retina are affected. It may help researchers better understand retinal vascular diseases, though some people will be excluded for safety or image-quality reasons.
Baltimore, MarylandAges 18–99 - NCT04521673Recruiting
Detecting causes of infectious eye inflammation
This trial looks for germs causing eye inflammation (uveitis) that may be due to an infection. It could help identify the best treatment for your condition.
ShanghaiAges Any age - NCT04591587Enrolling by invitation
Corneal lenticule implant for keratoconus
This trial tests a new surgical procedure using a small piece of corneal tissue (a lenticule) from a donor to strengthen the cornea in people with progressive keratoconus. The goal is to help stop the disease from getting worse.
PristinaAges 20–40 - NCT04504123RecruitingPhase 2
Doxycycline eye treatment for persistent wet macular degeneration fluid
This trial tests whether an “MMP-9 inhibitor” medicine given as doxycycline (a tetracycline-type antibiotic) can reduce persistent leaking and fluid in wet age-related macular degeneration. It may help people whose wet AMD is not fully controlled even after several anti-VEGF injections.
Iowa City, IowaAges 50–99 - NCT04547439RecruitingPhase 2
Melatonin for diabetic eye disease and better sleep
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Chicago, IllinoisAges 40–65 - NCT04439708Recruiting
Biomarkers for abnormal eye blood vessels
This study is looking for biomarkers (clues in your body) related to abnormal blood vessels in the eye. It may help researchers understand and treat conditions like macular degeneration.
ParisAges 18–90 - NCT04440280RecruitingPhase 2
NAC drops to improve cornea disease during cataract surgery
This Phase 2 study tests whether eye drops containing a medicine called N-acetylcysteine (NAC) can reduce damaging “reactive oxygen” in people with advanced Fuchs’ endothelial corneal dystrophy (FECD). It involves people who need a special cornea transplant (DMEK) at the same time as cataract surgery, aiming to improve cornea healing and vision.
Boston, MassachusettsAges 21 years+ - NCT04378790RecruitingPhase 3
Patch one eye by itself or together with glasses
This study tests whether children with amblyopia (lazy eye) should start patching one eye after glasses first, or start patching at the same time as glasses. The goal is to find the best approach to improve vision.
Birmingham, AlabamaAges 3–13 - NCT04402086Recruiting
Rheumatology patient and skin sample registry study at Yale
This study builds a health record and blood/skin sample collection for people with rheumatic autoimmune diseases who are getting care at Yale. It may help researchers understand these conditions and develop better tests or treatments over time.
New Haven, ConnecticutAges 18–99 - NCT04472130Recruiting
Neurodegenerative disease registry for adults
This study collects health information from adults with neurodegenerative diseases to help researchers learn more about these conditions and improve future care.
Hong KongAges 18–80 - NCT04381611Enrolling by invitation
Study of glaucoma surgeries and laser treatments over time
This study looks at people with glaucoma or high eye pressure to understand how surgeries and laser treatments affect long-term outcomes. It may help doctors predict which treatments work best for different patients.
Lausanne, Canton of VaudAges 1–100 - NCT04425434Recruiting
Treatment plan study for children with retinoblastoma
This trial looks at care recommendations for children with retinoblastoma (a childhood eye cancer). It may help standardize the best treatment approach for different patterns of tumor spread.
OuagadougouAges Up to 18 years - NCT04401982RecruitingPhase 4
Testing eye drops for blood flow in high eye pressure and glaucoma
This study tests whether three different eye drop treatments (netarsudil, latanoprost, or both together) can improve blood flow to the white part of the eye and the retina. It may help people with high eye pressure or who are glaucoma suspects better understand how these treatments work.
Baltimore, MarylandAges 18 years+
Common questions
- How many eyes & vision clinical trials are recruiting?
- Clin2 is tracking 1,760 recruiting ophthalmology studies from the U.S. registry right now, out of 2,756 we cover in this area in total.
- What does “Eyes & vision” cover here?
- Eye disease and conditions that affect sight. We group each study into eyes & vision based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a eyes & vision trial near me?
- Use the search to filter eyes & vision studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.