Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT05169333Recruiting
Oxford study using non-invasive imaging to learn risk factors
This study looks at factors that can predict health risks and uses non-invasive imaging (no major procedures) to collect information. It may help researchers better understand who is at higher risk over time and why.
Phoenix, ArizonaAges 18–99 - NCT05833048Recruiting
Pain-relief nerve block during cardiac surgery
This study tests whether a numbing “nerve block” placed in the rectus sheath area can reduce pain for people having certain heart surgeries with chest tubes. If you qualify, it may help your comfort during recovery, but it also depends on how suitable you are for local anesthesia.
New York, New YorkAges 18–85 - NCT07037446Enrolling by invitation
Occlutech leak device for mitral or aortic paravalvular leaks
This registry tracks the safety and effectiveness of a device designed to close leaks around heart valves (mitral or aortic). It may be an option for people who have significant symptoms like heart failure or anemia from these leaks and are not good candidates for surgery.
KatowiceAges 18 years+ - NCT06152575RecruitingPhase 3
Study of elranatamab for multiple myeloma that returned after other treatments
This trial tests a new medicine called elranatamab in people whose multiple myeloma has come back after they tried other treatments, including a specific type of immunotherapy (anti-CD38) and the drug lenalidomide. The goal is to see if this medicine can help control the cancer.
Mobile, AlabamaAges 18 years+ - NCT07448038RecruitingPhase 2
Study of selnoflast for heart artery inflammation
This trial tests a drug called selnoflast to see if it can reduce inflammation in the arteries of people with atherosclerosis (hardening of the arteries) who are at risk for heart attacks or other serious heart problems.
Beverly Hills, CaliforniaAges 18–80 - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT06770023RecruitingPhase 1
Bridge to lung transplant with ECMO for right heart failure
This study tests a special heart-lung support machine (ECMO) for people waiting for a lung transplant whose heart is failing due to high blood pressure in the lungs. The machine helps rest the heart and lungs until transplant surgery.
Jacksonville, FloridaAges 18–80 - NCT07640542RecruitingEarly Phase 1
Brain imaging study for Parkinson's and MSA patients
This early-stage research trial tests a new brain-imaging tracer called [11C]MODAG-005 to help doctors better understand Parkinson's disease (PD) and multiple system atrophy (MSA). You would undergo PET/CT and MRI scans twice, a few weeks apart, to see how reliable the imaging is.
Tübingen, Baden-WurttembergAges 50–75 - NCT06768489RecruitingPhase 1
Study of a new drug combination for multiple myeloma
This trial tests a new drug (JNJ-79635322) combined with other treatments like daratumumab or pomalidomide for people with multiple myeloma. It aims to see if these combinations are safe and effective for newly diagnosed or previously treated patients.
Denver, ColoradoAges 18 years+ - NCT07062471Recruiting
Shockwave balloon treatment for hardened carotid arteries before stenting
This study tests a special balloon that uses sound waves to break up calcium buildup in the carotid artery (the main artery in your neck) before placing a stent. It's for people who are at high risk for traditional surgery and have heavy calcium deposits in their artery.
Little Rock, ArkansasAges 18 years+ - NCT07737431Recruiting
Wrist-hand rehab device test for stroke survivors
This trial tests a new device that combines sensor and muscle signals to help you control wrist and hand movements after a stroke. It aims to improve your coordination and function.
Hung Hom, KowloonAges 30–70 - NCT07699029Recruiting
Clot removal for stroke in the back of the brain after 24 hours
This study tests a procedure to remove blood clots from large arteries in the back of the brain up to 14 days after a stroke starts. It may help people who have had a stroke more than a day ago and still have significant disability.
Wuhan, HubeiAges 18 years+ - NCT07720349Recruiting
Digital follow-up for heart disease patients
This trial tests a digital tool to monitor patients after a heart attack or stent procedure, using a smartphone or tablet to improve long-term care.
ArendalAges 18 years+ - NCT07737873Recruiting
Movement and brain function after chronic stroke
This study looks at how stroke affects your movement and nervous system over time. You will do simple movement tests and answer quality-of-life surveys to help researchers understand how to improve recovery.
Sacramento, CaliforniaAges 18 years+ - NCT07736885Recruiting
Hand stimulation for thinking problems after stroke
This study tests a gentle, painless electrical stimulation on specific points on the hands to see if it helps improve thinking and memory after a stroke. It is for people who have had a stroke in the last 2 weeks to 6 months and are noticing some cognitive changes.
Tianjin, Tianjin MunicipalityAges 35–80 - NCT06479174Recruiting
Cognitive strategies after stroke with family support
This study tests if combining cognitive exercises with a safe, mild brain stimulation can help improve memory and thinking after a stroke. It also looks at how shared family health history might affect recovery.
Albuquerque, New MexicoAges 18 years+ - NCT07581587Recruiting
Breathing Exercises and Brain Function in Heart Failure
This study tests whether special breathing exercises—done alone or while doing a mental task—can improve memory and thinking skills in people with heart failure. Researchers want to see if training your breathing muscles helps your brain work better.
Istanbul, FatihAges 40 years+ - NCT06953206Recruiting
Long-term study of a new heart valve for aortic stenosis
This study is testing a new heart valve called the SAPIEN 3 Ultra RESILIA valve for people with severe aortic stenosis. Researchers want to see how well it works and how safe it is over 10 years after a minimally invasive valve replacement procedure called TAVI.
Bad Oeynhausen, North Rhine-WestphaliaAges 18 years+ - NCT05032053Recruiting
Blood thinner use after stroke in people with small bleeds
This trial studies whether using blood-thinning medicine is safe and appropriate for people after an ischemic stroke who also have small signs of bleeding in the brain. It aims to balance stroke prevention with the risk of bigger bleeding.
Ankang, ShaanxiAges 40 years+ - NCT06711666Recruiting
Maternal mental health and baby's brain in heart disease
This study looks at how a mother's mental health during pregnancy may affect the brain development of babies with a serious heart condition called critical cyanotic congenital heart disease (CHD). It aims to understand this link to improve support for families.
MarseilleAges Up to 50 years - NCT07609862RecruitingPhase 1/Phase 2
Rocbrutinib and Lacutoclax for B-Cell Blood Cancers
This trial tests a combination of two new drugs (rocbrutinib and lacutoclax) to treat B-cell lymphomas and leukemias. The goal is to see if this combination works better than standard treatments, especially for patients whose cancer has come back or stopped responding to previous therapy.
TianjinAges 18 years+ - NCT05705531Recruiting
Cardiac MRI study of heart health after Hodgkin lymphoma treatment
This study looks at how certain blood-related “growth patterns” connect to long-term heart health after treatment for classical Hodgkin lymphoma. It may help doctors better predict who could develop heart problems and how to monitor them over time.
Mobile, AlabamaAges 7 years+ - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Andalusia, AlabamaAges 18–100 - NCT06552637Recruiting
Diaphragm stimulation for heart failure
This trial tests a device that stimulates your diaphragm (the muscle that helps you breathe) while you have heart failure. It may help improve your breathing and heart function. The study is for people with moderate heart failure symptoms whose heart pumps less blood than normal.
Tulsa, OklahomaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.