Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07491536Recruiting
Ozone therapy for mouth sores from cancer treatment
This trial tests if adding ozone therapy to a special mouthwash routine can help heal painful mouth sores caused by chemotherapy or radiation. It is for cancer patients with mild to moderate oral mucositis.
Pavia, LombardyAges 18 years+ - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+ - NCT07494747Recruiting
Toothpaste for sensitive gums
This trial tests a toothpaste for people with sensitive, inflamed gums (gingivitis). It looks at how well the toothpaste reduces gum bleeding and plaque.
Castelldefels, BarcelonaAges 18–65 - NCT07499596Recruiting
Black Mulberry Mouthwash for Gum Inflammation
This trial tests whether a mouthwash made from black mulberry (Morus nigra) can help treat gingivitis (gum inflammation). If you have gum disease but not advanced gum disease, you may be able to join for about 2 weeks of using the mouthwash along with regular brushing.
Battalgazi, MalatyaAges 18–65 - NCT07501455Recruiting
Studying toothpaste and mouth rinse effects on gum inflammation
This study tests whether using a certain toothpaste and mouth rinse can reduce gum inflammation (gingivitis) better than brushing alone. It is for people with mild to moderate gum disease who have not used tobacco or certain medications recently.
Somerville, MassachusettsAges 18–60 - NCT07501585Recruiting
Hyaluronic acid gel for infected back tooth surgery
This trial tests whether putting hyaluronic acid (a natural gel-like substance) into the bone during root-end surgery helps heal infections in first molars (back teeth) that didn't get better after a root canal. It may be a good option if you have a small, stubborn infection and your gums are healthy.
MoscowAges 18 years+ - NCT07507474Recruiting
New treatment for gum disease (Bioperio protocol)
This trial tests a treatment called Bioperio for people with gum disease (periodontitis) who have not been treated before. It looks at how well the treatment works over time.
Pisa, None SelectedAges 18 years+ - NCT07507734Recruiting
Splint and exercise therapy for jaw joint pain
This trial tests whether a custom mouth splint combined with jaw exercises can reduce pain in the jaw joint (TMJ). It may help people who have had jaw joint pain for at least 3 months.
Istanbul, TuzlaAges 18–65 - NCT07508033RecruitingPhase 1/Phase 2
Stem cell exosomes vs platelet-rich fibrin for socket healing
This trial tests whether stem cell exosomes (tiny healing particles from stem cells) work better than platelet-rich fibrin (a blood-derived clot) to help a tooth socket heal after extraction. It may help if you need a single front or premolar tooth removed and are generally healthy.
Tanta, Gharbia GovernorateAges 20–45 - NCT07509619Recruiting
AI physiotherapy evaluation for oral cancer patients
This study is testing a new AI-based system that helps evaluate mouth and jaw movement (range of motion) in oral cancer patients. It enrolls healthy volunteers without any head or neck problems to gather normal movement data.
TaipeiAges 20–70 - NCT07513792Recruiting
3D imaging to prevent gum shrinkage during clear aligner treatment
This study tests whether a special 3D imaging tool helps protect your gums from pulling back (receding) while straightening your teeth with clear aligners. Gum recession can expose tooth roots and cause sensitivity, so the trial is exploring whether better visualization during treatment planning prevents this problem.
Liège, LiegeAges 18 years+ - NCT07517172Recruiting
Brain Stimulation Patch for Jaw Pain: Home Treatment Study
This study tests whether a small, stick-on electrical patch placed on your ear can reduce temporomandibular disorder (TMD) jaw pain when used at home. You would apply the patch yourself and complete surveys about your pain to help researchers learn if this non-invasive approach is safe and feasible.
Minneapolis, MinnesotaAges 18–65 - NCT07517926Recruiting
Chewing gum and cold water gargle after lung breathing tube procedure
This study tests whether chewing gum and gargling with cold water can reduce sore throat and other discomfort after a bronchoscopy—a procedure where doctors look inside your airways with a thin camera. If it works, it could be a simple, safe way to feel better after the procedure.
AnkaraAges 18 years+ - NCT07518615Recruiting
Safety and Effectiveness of Guided Dental Implant Surgery System
This trial tests a new computer-guided system (Straumann Dynamic Navigation Falcon) that helps dentists place dental implants more precisely. If you need one or more dental implants and have healthy gums and jaw, this study may help determine if this guided approach is safe and works well.
GhentAges 18 years+ - NCT07521267Recruiting
Nano-coated screws for teeth straightening in teens
This trial tests special small screws coated with nano-material to help move upper front teeth back into place during braces treatment. The screws act as anchors to make tooth movement more effective for patients with protruding upper front teeth.
Cairo, Cairo GovernorateAges 14–20 - NCT07522684Recruiting
Gel treatment for deep gum bone loss around teeth
This trial tests a special gel made with growth-promoting compounds and animal-derived material to help repair deep bone loss in the gums around teeth. It may help restore bone that periodontitis (advanced gum disease) has damaged.
Ribeirão Preto, São PauloAges 18 years+ - NCT07523802Recruiting
Managing pain after gum graft surgery with two methods
This trial tests two different ways to protect and manage pain in the mouth after a gum graft surgery. You would compare a product called Ora-Aid with a custom acrylic stent (a protective cover) to see which helps with healing and reduces discomfort better.
CairoAges 18 years+ - NCT07526129Recruiting
Ridge Preservation After Back Tooth Extraction
This study looks at whether a procedure called ridge preservation, done after removing upper back teeth, helps prevent the need for sinus bone grafting later. Researchers will compare patients who had this procedure with those who didn't, using 10 years of X-ray records.
Beirut, BeirutAges 18 years+ - NCT07526259Recruiting
Novel gum recession surgery compared to standard technique
This study compares two surgical approaches to treat multiple areas of receded gums (where gum tissue has pulled back from teeth). Both techniques use grafted tissue to restore gum coverage and protect tooth roots.
Cairo, AlManialAges 18 years+ - NCT07526350RecruitingEarly Phase 1
MTS109 for Hard-to-Treat Autoimmune Diseases
This early-stage trial tests a new treatment called MTS109 for autoimmune diseases (like lupus, muscle inflammation, scleroderma, vasculitis, or Sjögren's syndrome) that haven't responded well to standard medications. The goal is to see if MTS109 can help control disease that keeps flaring or getting worse despite current treatments.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07526337Recruiting
Digital Planning for Sinus Lift Dental Implants
This study examines how computer planning improves dental implant surgery when bone needs to be built up in the upper back jaw. Researchers will assess whether digital planning helps predict better outcomes for patients getting sinus lift procedures.
Beirut, BeirutAges 18 years+ - NCT07529444Recruiting
Testing ways to clean dental implants affected by infection
This study tests different methods to clean and treat dental implants that have developed an infection around them (peri-implantitis). The goal is to find the best way to remove harmful bacteria and save your implant.
ZagrebAges Any age - NCT07530978Recruiting
Oral Health, Gum Disease, and Quality of Life Study
This study looks at how gum health affects daily life and quality of living. Researchers want to understand the connection between oral hygiene habits, gum disease status, and how patients feel overall.
Bolu, BoluAges Any age - NCT07531875Recruiting
Probiotics to Help Treat Advanced Gum Disease
This trial tests whether taking probiotics (beneficial bacteria) alongside standard gum disease treatment can help reduce deep pockets in your gums and improve healing. You'd be asked to take probiotics as an add-on to the care you're already receiving.
Kuala Lumpur, Kuala LumpurAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.