Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,406 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2783
- Phase 1576
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3124
Top conditions
- Stroke841
- Parkinson Disease427
- Alzheimer Disease342
- Multiple Sclerosis341
- Dementia227
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Insomnia154
- Spinal Cord Injuries153
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment130
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida275
- Texas265
- Maryland246
- Arizona212
- Alabama210
- Illinois188
- Pennsylvania177
Recruiting studies12,404 total
- NCT07746947Recruiting
Stroke treatment study for medium-sized vessel blockages
This study looks at how well a procedure to remove blood clots from medium-sized brain arteries works for people who have had a severe stroke. It may help improve recovery by treating blockages that are not in the largest arteries.
Indianapolis, IndianaAges 18–85 - NCT07747961Recruiting
Virtual reality games for children with cerebral palsy
This trial tests whether playing virtual reality games, designed as part of a rehab program, can help improve movement and daily skills in children with a specific type of cerebral palsy (spastic diplegia). It may be a fun and engaging way to support physical therapy.
IslamabadAges 7–15 - NCT07747324RecruitingPhase 1/Phase 2
Testing ayahuasca for psychogenic non-epileptic seizures
This trial tests whether a single dose of ayahuasca, a plant-based brew, can reduce psychogenic non-epileptic seizures (PNES). It may help if you are willing to stop psychiatric medications temporarily and have no other serious mental health conditions.
Ribeirão Preto, São PauloAges 18–60 - NCT07620938RecruitingPhase 2
TJ0113 capsule for treating muscle loss in older adults
This study tests a new capsule called TJ0113 to see if it can help older adults with sarcopenia (muscle loss) improve their muscle strength and physical function. It's a phase 2 study, meaning the drug is being tested for safety and effectiveness.
Hangzhou, ZhejiangAges 60 years+ - NCT05807269Recruiting
Stroke prevention and rehabilitation program in Uganda
This program focuses on helping people who have had a stroke, or who have stroke risk factors, through prevention and rehabilitation support. It may help you improve recovery and lower the chance of another stroke.
HoimaAges 13 years+ - NCT06139523Recruiting
Improving eye imaging in adults and children
This study aims to improve how we take pictures of the back of the eye (called OCT imaging) in both healthy adults and children. It will help doctors get better images to diagnose and manage eye conditions.
Durham, North CarolinaAges Any age - NCT02523014RecruitingPhase 2
Drug combo for meningioma that keeps growing despite treatment
This Phase 2 trial tests several targeted medicines (given together or by specific assignment) for meningiomas inside the brain that are progressing or not fully removed after surgery. It may help slow the tumor’s growth and improve symptoms by blocking tumor growth pathways.
Birmingham, AlabamaAges 18 years+ - NCT07674667RecruitingPhase 1/Phase 2
Testing a treatment to restore UNC13A function in ALS
This trial tests a new treatment aimed at restoring the function of a gene called UNC13A in people with ALS. It involves multiple clinic visits, MRI scans, and spinal taps to see if the treatment is safe and may slow the disease.
MunichAges 18–75 - NCT06869967Recruiting
Pain Control After Ear Surgery (Mastoidectomy)
This study tests a pain-blocking injection to reduce pain after a specific type of ear surgery (mastoidectomy). It may help you feel less pain after your operation.
IstanbulAges 18 years+ - NCT07399171RecruitingPhase 2
Testing HT-4253 to prevent Alzheimer's in APOE4 carriers
This trial tests an experimental drug called HT-4253 to see if it can prevent Alzheimer's disease in people who are at higher genetic risk (carry the APOE4 gene) and have early signs of amyloid buildup in the brain. If you qualify, you would take the drug or a placebo and be monitored over time.
Abu Dhabi, Abu Dhabi EmirateAges 50–75 - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT07531745RecruitingPhase 1/Phase 2
ION337 gene therapy for children with Dravet syndrome
This study tests a new gene therapy called ION337 designed to treat Dravet syndrome, a severe childhood epilepsy caused by a SCN1A gene mutation. The therapy is given as a spinal fluid injection and aims to reduce seizures in children ages 2–12.
Ann Arbor, MichiganAges 2–12 - NCT07587125RecruitingPhase 1
CAR-T Cell Therapy for Progressive Multiple Sclerosis
This trial tests a new cell therapy called S103 for people with MS that isn't responding well to standard treatments. The therapy involves modifying immune cells in the lab and putting them back into your body to help control the disease.
Xi'an, ShaanxiAges 18–75 - NCT06001749RecruitingPhase 2
Psilocybin for cancer pain study
This trial tests whether psilocybin (a psychedelic drug) can help with severe cancer pain. You may qualify if your pain is high despite strong medications and you are willing to be monitored closely.
Boston, MassachusettsAges 18 years+ - NCT07434037Recruiting
Trust and the brain in Down syndrome and Fragile X
This study explores how people with Down syndrome or Fragile X syndrome learn to trust others. It uses simple tasks and a brain scan (MRI) to compare their responses with those of typically developing children and young adults.
BronAges 3–29 - NCT06154356Recruiting
Watching and imagining movements to help Parkinson's
This study tests whether watching guided movement videos and then imagining those movements can improve walking and movement in people with Parkinson's. It may help if you are in early to moderate stages and don't have serious thinking or health problems.
Karaman, KaramanAges 18–65 - NCT06166862Recruiting
Mirroring and imagining movements after stroke
This study tests if watching and imagining movements can help people who had a stroke within the last year walk better and move easier.
Karaman, KaramanAges 18–65 - NCT06872125RecruitingPhase 3
Testing zorevunersen for Dravet syndrome
This study tests an experimental drug called zorevunersen for people with Dravet syndrome. It aims to see if the drug can reduce seizures and improve safety.
Phoenix, ArizonaAges 2–17 - NCT07678437Enrolling by invitation
Blood flow restriction exercise for strength after spinal cord injury
This trial tests whether controlled exercise with blood flow restriction (a gentle technique) can help you regain strength after an incomplete spinal cord injury. It is for people currently receiving care at Quality Living, Inc.
Omaha, NebraskaAges 19–75 - NCT06197685Recruiting
Combining treatments to improve memory in multiple sclerosis
This trial tests a combination of two approaches to help people with MS improve memory and learning. If you have mild-to-moderate mobility issues and are not very active, you may be able to join.
East Hanover, New JerseyAges 18–70 - NCT07420738Recruiting
Brain protection during heart bypass surgery study
This trial studies whether different circulatory support techniques during coronary artery bypass surgery affect blood flow to the brain. It may help find ways to protect brain function during the procedure.
IstanbulAges 18–75 - NCT06180837Recruiting
Can longer sleep improve heart health in overweight adults?
This study tests if getting more sleep (7+ hours) can lower certain fats in the blood called ceramides, which are linked to heart disease risk. It's for overweight adults who currently sleep less than 6.5 hours a night.
Salt Lake City, UtahAges 18–45 - NCT07552896Recruiting
Screen Time and Recovery Confusion After Children's Surgery
This study looks at whether the amount of time children spend on screens (phones, tablets, TV) before surgery affects confusion and agitation as they wake up from anesthesia. Researchers want to understand this connection to help reduce distressing wake-up experiences.
Istanbul, IstanbulAges 2–11 - NCT07389694Recruiting
Brain stimulation for stuttering: a TMS study
This study tests whether a non‑invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can help reduce stuttering. The trial involves sitting in a chair while a magnetic coil gently stimulates parts of your brain that control speech.
Manhattan, KansasAges 18–65
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,406 recruiting neurology studies from the U.S. registry right now, out of 19,323 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.