Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,435 recruiting studies in this area right now.
By phase
- Not applicable9,772
- Phase 2786
- Phase 1573
- Phase 3535
- Phase 4342
- Phase 1/Phase 2304
- Phase 2/Phase 3123
Top conditions
- Stroke846
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy196
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts300
- New York291
- Florida274
- Texas268
- Maryland245
- Arizona214
- Alabama209
- Illinois190
- Pennsylvania177
Recruiting studies12,433 total
- NCT06296745RecruitingPhase 2
Pemetrexed in spinal fluid for lung cancer that spread to brain lining
This trial tests a drug called pemetrexed, given directly into the fluid around the spinal cord (intrathecal), for people with lung cancer that has spread to the brain and spinal cord lining and is no longer controlled by the targeted therapy osimertinib.
Huizhou, GuangdongAges 18–75 - NCT06296875Recruiting
Krill oil for muscle health in older adults
This study tests whether taking a daily krill oil supplement can help improve muscle health in people aged 65 and older. It aims to find out if the natural omega-3s in krill oil can slow age-related muscle changes.
GlasgowAges 65–90 - NCT06297863RecruitingPhase 2
Head-down position to improve blood flow in stroke
This study tests whether lying with your head tilted down 15 degrees can improve blood flow to the brain during a stroke. It is for people who have a clot in the middle cerebral artery and are already getting a procedure to remove the clot.
AvezzanoAges 18 years+ - NCT06297590RecruitingPhase 1
First human study of a new Alzheimer's drug
This study tests an experimental drug (LY3954068) for people with early Alzheimer's disease. It aims to see if the drug is safe and may slow memory loss. You'll need a PET scan to measure tau protein in the brain and have a study partner who can help attend appointments.
Maitland, FloridaAges 50–85 - NCT06298474Recruiting
BRAIN App for dementia support
This study is testing a new app (BRAIN App) designed to help people with dementia stay connected and engaged. Researchers want to see if the app can be useful for older adults who can still communicate and have not had a recent fast decline in health.
Winchester, MassachusettsAges 65 years+ - NCT06298019RecruitingPhase 1
CAR T-cell therapy for tough dermatomyositis
This study tests a new immune therapy called CAR T-cells (KYV-101) for people with active, tough-to-treat dermatomyositis. It aims to see if the treatment is safe and can reduce muscle weakness and skin rash.
Palo Alto, CaliforniaAges 25–72 - NCT06298565Recruiting
Safety study of efgartigimod for generalized myasthenia gravis
This study looks at how safe efgartigimod is for people with generalized myasthenia gravis (gMG), whether they are taking the drug now, will start it soon, or are not taking it at all.
San Francisco, CaliforniaAges 18 years+ - NCT06299891RecruitingPhase 2
Study of weight loss medication for youth with hypothalamic obesity
This study tests a combination of two medications, phentermine and topiramate, to see if they help young people with hypothalamic obesity lose weight safely. Hypothalamic obesity is rapid weight gain caused by injury to the hypothalamus, often from a brain tumor or its treatment.
Philadelphia, PennsylvaniaAges 6–28 - NCT06299748Recruiting
Efgartigimod safety study for pregnancy and breastfeeding
This study is for women who have taken efgartigimod (a medicine for certain autoimmune conditions) right before or during pregnancy, or while breastfeeding. Researchers will monitor moms, fetuses, and babies to check for side effects and ensure safety.
Morgantown, West VirginiaAges Any age - NCT06300307RecruitingPhase 1/Phase 2
Study of ATX-01 for Myotonic Dystrophy Type 1
This trial tests an experimental drug called ATX-01 for people with myotonic dystrophy type 1 (DM1), a condition that causes muscle weakness and stiffness. The study aims to see if ATX-01 can help reduce symptoms like muscle stiffness (myotonia) and improve daily function.
Los Angeles, CaliforniaAges 18–64 - NCT06300541Recruiting
Sarcopenia in inflammatory bowel disease flare-ups
This study looks at how common muscle loss (sarcopenia) is in people with inflammatory bowel disease during a flare-up, and what impact it has. By participating, you may help doctors better understand and treat muscle weakness in IBD.
GothenburgAges 18 years+ - NCT06301412RecruitingPhase 3
Cooling plus clot removal for acute stroke
This trial tests whether cooling the body down (hypothermia) combined with a clot removal procedure (thrombectomy) helps people recover better from a large-artery stroke. You may be eligible if you have a moderate-to-severe stroke and can be treated within 24 hours of when you were last seen well.
Freiburg im BreisgauAges 18 years+ - NCT06301776Recruiting
Shorter vs. longer blood thinners after bridge stent for neck artery
This trial compares two different lengths of blood-thinner therapy after getting a Bridge stent for a narrowed artery in the back of the neck. It aims to find the best way to prevent future strokes with fewer side effects.
Shenyang, LiaoningAges 18–80 - NCT06302946Recruiting
Brain therapy with electrical stimulation and mindfulness for stroke patients
This study tests if combining neuromuscular electrical stimulation (gentle muscle zaps) with mindfulness exercises helps stroke patients recover better. It aims to improve movement and well-being.
Cairo, DokkiAges 50–65 - NCT06303921RecruitingEarly Phase 1
Study of a new brain imaging agent for Parkinson's disease
This trial uses a special PET scan to see how a new imaging agent (called 11C-M503) travels through the body and brain. It may help researchers better understand brain conditions like Parkinson's disease.
New Haven, ConnecticutAges 40–85 - NCT06303180Recruiting
Collecting tissue and fluid samples for ear, nose, and throat research
This study collects samples like tissue, blood, or saliva from people with hearing, balance, smell, taste, voice, speech, or language problems, as well as from healthy volunteers. The samples help researchers better understand these conditions and develop new ways to diagnose or treat them.
Bethesda, MarylandAges 3–99 - NCT06303960RecruitingEarly Phase 1
Brain stimulation for chronic stroke arm recovery
This early-phase trial tests whether brain stimulation (deep brain stimulation in the cerebellum or vagus nerve stimulation) can help improve arm and hand movement in people who had a stroke 1 to 3 years ago.
Jinan, ShandongAges 30–75 - NCT06303869Recruiting
Deep brain stimulation for speech after stroke
This study tests if deep brain stimulation (a small device implanted in the brain) can improve speech and arm movement after a stroke that affected the deeper parts of the brain. It is designed for people who have trouble speaking clearly (dysarthria) from their stroke.
Pittsburgh, PennsylvaniaAges 18–75 - NCT06304389Recruiting
Blue light therapy for epilepsy with vagus nerve stimulation
This trial tests if blue light exposure can improve the effects of vagus nerve stimulation (VNS) in people with epilepsy that is hard to control. It also includes some healthy volunteers for comparison. The goal is to find new ways to make VNS work better.
Woluwe-Saint-LambertAges 18–60 - NCT06305234Recruiting
Long-term immune response study for Palynziq PKU treatment
This long-term study checks how the immune system reacts to Palynziq (a treatment for PKU) over time. It involves extra blood tests for people already in another PKU study called 165-501.
Aurora, ColoradoAges Any age - NCT06304285Recruiting
Acupuncture for Parkinson's with chronic appendicitis
This trial tests whether acupuncture can help people with Parkinson's disease who also have chronic appendicitis. It aims to see if treating the appendix inflammation may also improve Parkinson's symptoms.
Hefei, AnhuiAges 40–70 - NCT06304441Recruiting
Pemetrexed plus lung cancer pill for brain metastasis
This trial tests if adding an injected chemotherapy drug (pemetrexed) to a targeted oral pill (like osimertinib) works better than the pill alone for patients with lung cancer that has spread to the brain and spinal cord lining.
Huizhou, GuangdongAges 18–75 - NCT06306092Recruiting
Sleep for better mental health and school grades
This study looks at how helping teenagers sleep better can improve their mental health and school grades. It is open to students in Swedish high schools and upper secondary schools.
Kristianstad, Skåne CountyAges 13–19 - NCT06308029Recruiting
E-health pain self-management for breast cancer survivors
This trial tests an online program to help people manage lasting pain after breast cancer treatment. It's designed for those whose pain still gets in the way of daily life, even after finishing primary treatment.
AntwerpAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,435 recruiting neurology studies from the U.S. registry right now, out of 19,491 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.