Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,976 recruiting studies in this area right now.
By phase
- Not applicable7,959
- Phase 2483
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke841
- Heart Failure567
- Hypertension401
- Cardiovascular Diseases390
- Coronary Artery Disease372
- Multiple Myeloma334
- Atrial Fibrillation268
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California460
- Alabama197
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,973 total
- NCT07040189Recruiting
AI nutritional plan for taste changes from chemo
This study tests an AI-created diet plan to help with taste problems caused by chemotherapy. It may help manage taste issues by suggesting recipes tailored to you.
Munich, BavariaAges 18 years+ - NCT07460882Recruiting
Low sodium salt substitute and potassium levels in high blood pressure
This study tests whether using a low-sodium salt substitute can keep your potassium levels safe while you manage your high blood pressure. It's for adults with high blood pressure who are already on stable medications.
DhakaAges 18 years+ - NCT07595068Recruiting
Ultrasound for Sleep and Heart Function Before Heart Surgery
This trial tests a new treatment using focused ultrasound to help regulate your nervous system and improve sleep quality before heart surgery. The goal is to help reduce anxiety and improve how well you sleep during the time leading up to and after your cardiology procedure.
Huangshi, HubeiAges 18–79 - NCT03567213Recruiting
CortiCom brain signal system for communication in severe paralysis
This trial tests a system that records brain signals to help people with severe paralysis and little or no speech communicate. It involves a surgical implant and frequent study visits to see if the system can work safely and reliably for communication.
Baltimore, MarylandAges 22–70 - NCT05594368RecruitingPhase 1
Test targeted radiation to treat recurrent ventricular tachycardia
This trial studies a radiation approach (called stereotactic body radiation therapy, or SBRT) to treat ventricular tachycardia (a dangerous heart rhythm) that keeps coming back. It aims to reduce the rhythm episodes in people who have already tried catheter ablation (a procedure to cauterize rhythm sources) or cannot have it.
OstravaAges 18 years+ - NCT07775976Enrolling by invitation
Whole-heart checkup with a wearable heart monitor
This study looks at how well a wearable heart monitor and special software can check the health of your whole heart and assess your risk of future heart problems. It may help doctors create more personalized care plans.
Pasadena, CaliforniaAges 18 years+ - NCT06118983Recruiting
Improving care transitions for heart failure patients in home health
This trial tests a program called I-TRANSFER-HF to improve how heart failure patients move from hospital to home with home health care. It aims to help you have a smoother recovery and avoid coming back to the hospital.
New York, New YorkAges 18 years+ - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18 years+ - NCT05862558Recruiting
Lithotripsy to open blocked, calcified artery for TAVR
This trial tests whether a treatment called intravascular lithotripsy (using sound waves from inside a blood vessel) can help widen severely calcified, narrowed iliac arteries so a TAVR procedure can be done through the groin. It may help some people who are considered “high risk” for access, based on CT scan findings.
Plano, TexasAges 18–90 - NCT06824961Recruiting
Comparing 3 vs 5 second pauses during CPR for cardiac arrest
This trial is testing whether increasing the pause in chest compressions from 3 to 5 seconds during CPR helps improve breathing support and the chance of restarting the heart. It involves adults who had a cardiac arrest outside the hospital and were treated with a mechanical compression device called LUCAS.
Amsterdam, North HollandAges 16 years+ - NCT07288489RecruitingPhase 3
A study on VMX-C001 for urgent surgery while on blood thinners
This trial tests a drug called VMX-C001 to quickly reverse the effects of certain blood thinners (Factor Xa inhibitors) in people who need urgent surgery with a high risk of bleeding. It compares VMX-C001 to standard care to see which is more effective at helping blood clot normally.
Chandler, ArizonaAges 18 years+ - NCT07449130Recruiting
AI screening for valve disease using chest CT scans
This study uses a computer AI to look at routine chest CT scans and find people who might have valvular heart disease (problems with the heart's valves). It aims to see if AI can help catch these issues early, so you can get the right care sooner.
Wuhan, HubeiAges 18 years+ - NCT07101328RecruitingPhase 1
Study of LY4152199 for Lymphoma That Returned or Didn't Respond
This study tests a new medicine called LY4152199 for people with certain types of lymphoma (follicular or diffuse large B-cell) that came back or didn't respond to previous treatment. The goal is to see if the drug is safe and how well it works.
Duarte, CaliforniaAges 18 years+ - NCT07058077RecruitingPhase 2/Phase 3
Study of oral cholesterol-lowering pill in children with HeFH
This study tests an experimental daily pill (enlicitide decanoate) that lowers LDL ('bad') cholesterol in children and teens with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see if this medicine can safely help reduce their high cholesterol levels.
Wilmington, DelawareAges 6–17 - NCT07521007RecruitingPhase 2
YN001 treatment for coronary artery disease
This study tests whether a new drug called YN001 can help people with coronary atherosclerosis (narrowing of heart blood vessels). The trial aims to see if it can improve outcomes in people who have early-stage blockages in their heart arteries.
Huntsville, AlabamaAges 18–80 - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT07587294Recruiting
Ultrasound Treatment to Prevent Heart Rhythm Problems After Heart Attack
This trial tests whether a special ultrasound procedure on the side of your neck can help prevent dangerous irregular heartbeats in patients who recently had a heart attack treated with a stent. The goal is to see if this treatment is safe and effective.
Huangshi, HubeiAges 18–80 - NCT07621003Recruiting
PULSed Field Ablation for New-Onset Atrial Fibrillation
This study tests a newer ablation technique using pulsed electrical energy to treat atrial fibrillation (an irregular heartbeat). You may qualify if you were recently diagnosed with AF and haven't had ablation before.
Bad OeynhausenAges 18 years+ - NCT06871462Enrolling by invitation
Texting program to help monitor blood pressure at home
This study tests a program that uses text messages to help people with high blood pressure check and manage their blood pressure at home. It may help you better control your blood pressure and reduce health risks.
San Francisco, CaliforniaAges 18 years+ - NCT05923489Recruiting
Follow-up angiography after stent placement in high-risk patients
This study checks how routine repeat heart blood-vessel imaging (angiography) after stent placement may help high-risk patients. It is meant for people who had a successful stent procedure and have certain higher-risk heart features.
Hangzhou, ZhejiangAges 18 years+ - NCT03504956Recruiting
MRI study to map early heart artery plaque changes
This study uses an MRI scan to better “see and measure” early changes in the heart’s artery lining. It may help researchers understand coronary artery disease earlier, even before it causes symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT07534917Recruiting
New Pacemakers and Heart Function Study
This study compares newer pacemaker types to see how well they work and how they affect your heart's pumping ability and valve function over a short period. You'll be monitored closely with heart imaging to understand which pacemaker performs best.
LondonAges 18 years+ - NCT07223593RecruitingPhase 3
Orforglipron for peripheral artery disease with leg pain
This trial tests a new oral medication called orforglipron to see if it can improve walking distance in people with peripheral artery disease (PAD) who have leg pain when walking. It may be a good option if you have PAD and your walking is limited by leg cramping, not other health issues.
Birmingham, AlabamaAges 18 years+ - NCT07157774RecruitingPhase 3
Muvalaplin for heart disease in people with high lipoprotein(a)
This study tests a new medicine called muvalaplin that lowers a specific type of cholesterol linked to heart disease. It aims to see if muvalaplin can reduce the risk of future heart attacks, strokes, or related procedures in people with high levels of this cholesterol.
Birmingham, AlabamaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,976 recruiting cardiology studies from the U.S. registry right now, out of 15,179 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
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- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.