Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT07024420Recruiting
Sigh breathing during heart surgery with heart-lung machine
This study tests if adding occasional deep breaths (sighs) during heart surgery helps patients recover better after using the heart-lung machine. It is for people having planned (not emergency) heart surgery.
Nanjing, JiangsuAges 18 years+ - NCT07331103Recruiting
Can a special diet reduce inflammation for heart health?
This study tests whether a special diet can reduce inflammation and improve heart health in people over 55 who are at increased risk for heart disease but have not yet had a heart attack or stroke.
Avellino, AVAges 55 years+ - NCT06822946RecruitingPhase 2
Zhibitai Capsules for High Cholesterol
This trial tests if Zhibitai Capsules can lower high cholesterol in people with primary hyperlipidemia (high fat levels in the blood). It may be a treatment option for those who cannot take standard medications.
Changsha, HunanAges 18–75 - NCT06516315Recruiting
Blood flow measurement during leg artery procedure
This study tests a new way to measure blood flow during a leg artery procedure. It may help doctors decide if a stent is needed, using a special software that analyzes X-ray images instead of a separate wire in the artery.
Paris, Île-de-France RegionAges 18 years+ - NCT06123728Recruiting
Using MCG to assess heart blood flow in stable artery disease
This trial is testing a new magnetic heart scan (called MCG) to see if it can better detect when your heart isn't getting enough blood. It is for people with stable chest discomfort and a previous heart CT that showed moderate blockages in the arteries.
Foshan, GuangdongAges 18 years+ - NCT06124664Recruiting
Study of leg vein drainage in pelvic varicose veins
This study looks at how blood flows from the legs in people with varicose veins in the pelvis. It may help doctors understand the link between pelvic and leg vein problems.
MoskvaAges 18–40 - NCT07027202Recruiting
Early heart unloading for severe shock after ECMO
This trial tests a possible treatment to help the heart recover faster in people who need ECMO support for severe cardiogenic shock (when the heart can't pump enough blood). The treatment involves early use of a device to reduce pressure on the heart's main pumping chamber.
Clermont-FerrandAges 18 years+ - NCT04180085RecruitingPhase 2
Belatacept to protect kidneys in heart transplant patients
This trial studies whether belatacept can be used after a heart transplant to help protect kidney function over time. It focuses on people who already have (or are at risk for) worsening kidney function after transplant, while avoiding those with certain infections or rejection concerns.
BordeauxAges 18 years+ - NCT06499844RecruitingEarly Phase 1
Tests to measure blood flow in skin
This study looks at how blood vessels in the skin widen in response to a natural chemical called nitric oxide. By testing healthy young adults, researchers hope to improve a simple skin test that could one day help detect early blood vessel problems.
Iowa City, IowaAges 18–30 - NCT06515730RecruitingPhase 4
Apixaban vs warfarin for left ventricle clot after heart attack
This trial tests whether a newer blood thinner, apixaban, works better than the standard warfarin for treating blood clots in the left ventricle after a heart attack. The goal is to see which medication is safer and more effective at preventing complications.
FalunAges 18 years+ - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT06823947RecruitingPhase 1
Study of KK3910 in healthy people and those with high blood pressure
This study tests a new medicine called KK3910, first in healthy volunteers to check safety, then in Japanese patients with essential hypertension (high blood pressure) to see if it helps lower blood pressure.
Hakata, FukuokaAges 18–80 - NCT06874192RecruitingPhase 1
Low-dose colchicine for statin intolerance pilot study
This trial tests if a low dose of colchicine can help people who cannot take statins due to side effects. It aims to see if colchicine is safe and effective for lowering inflammation and improving cholesterol management.
Richmond, VirginiaAges 18–80 - NCT06105242Recruiting
Sex differences in CTEPH heart function and recovery
This study looks at how CTEPH (a type of high blood pressure in the lungs caused by blood clots) affects heart function differently in men and women. It uses heart ultrasounds and pressure measurements to see if recovery after surgery differs by sex.
Murray, UtahAges 18 years+ - NCT07593027RecruitingPhase 1/Phase 2
Study of IMC-003 for pulmonary arterial hypertension
This trial tests a new drug called IMC-003 for people with pulmonary arterial hypertension (PAH). It aims to see if the drug can help improve symptoms and exercise ability when added to your current PAH medications.
Beijing, Beijing MunicipalityAges 18–75 - NCT06036615Recruiting
Exercise training for frailty and fall risk in heart failure
This trial tests whether a supervised exercise program can reduce frailty and fall risk in people with chronic heart failure, and what happens when training stops. It may help you feel stronger and more stable.
Thessaloniki, ThermiAges 18–100 - NCT06148935Recruiting
Study of vericiguat in Korean heart failure patients
This study looks at how well Verquvo (vericiguat) works in daily life for Korean adults with chronic heart failure and a weak heart pump. It’s for people whose heart failure has recently gotten worse and who are starting Verquvo for the first time.
Multiple LocationsAges 19 years+ - NCT05481723RecruitingPhase 3
Lung ultrasound to guide fluid and blood pressure during surgery
This Phase 3 study tests whether using a lung ultrasound scan during surgery can better guide blood pressure and fluid needs. It may help stabilize patients during long operations and reduce complications related to poor circulation or fluid balance.
AmiensAges 18 years+ - NCT06523166Recruiting
Comparing heart CT and ultrasound for Watchman device checking
This study compares two types of heart imaging (a CT scan and an ultrasound) to see how well they work at checking the Watchman device after it is placed. The goal is to see if the CT scan might be a good alternative to the standard ultrasound for follow-up.
Los Angeles, CaliforniaAges 18 years+ - NCT05944146Recruiting
Tests two methods for measuring heart blood flow during surgery
This trial compares a neck ultrasound test (carotid Doppler) with a heart monitoring method (thermodilution) to see if they give consistent blood-flow readings. It may help clinicians measure circulation more reliably in people having heart surgery.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06828432Enrolling by invitation
Device study for heart surgery patients in the heart intensive care unit
This trial tests a new device that measures heart function closely after heart surgery. It may help doctors give better care if you are in the heart intensive care unit after your operation.
Pittsburgh, PennsylvaniaAges 18–105 - NCT04332692Recruiting
Check if a lung ultrasound helps evaluate discharge after heart failure
This study looks at whether doing lung ultrasounds can better assess people right before they leave the hospital after an acute heart failure flare. It may help doctors decide when someone is ready for discharge and tailor care to reduce risk after leaving.
Vandœuvre-lès-NancyAges 18 years+ - NCT05941013Recruiting
Ultrasound-check breathing tube during heart procedures
This feasibility study tests a special breathing tube that can be checked with ultrasound during a planned heart catheter procedure under general anesthesia. It may help doctors confirm the tube is in the right place more easily and safely, before and after the procedure.
Ann Arbor, MichiganAges 6 months–3.5 years - NCT07148817Recruiting
Do earplugs help with noise-related heart disease?
This study tests if wearing earplugs at night can lower the negative effects of traffic noise on your heart health. It looks for people who are bothered by noise or live in a noisy area and have heart disease or risk factors like high blood pressure.
Boston, MassachusettsAges 18–65
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.