Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT04861506Recruiting
Clot-removal treatment for blocked blood flow in the leg
This trial tests how safe and effective a clot-removal procedure done through the blood vessels is for people with acute or subacute blocked blood flow in the lower leg. It may help by improving circulation while carefully tracking risks and results.
Hangzhou, ZhejiangAges 18 years+ - NCT04862468RecruitingPhase 2
Dexamethasone after clot removal to calm leg swelling
This Phase 2 study tests whether a steroid medicine called dexamethasone can reduce inflammation after a clot (DVT) is removed in the thigh/behind-knee veins. If it works, it may help improve recovery and reduce ongoing leg problems after the procedure.
Orange, CaliforniaAges 18–89 - NCT04862507Recruiting
Thrombectomy treatment for severe stroke with low ASPECTS
This trial studies an approach for removing a blockage using thrombectomy in people with an acute ischemic stroke that shows a low ASPECTS score. It may help restore blood flow in strokes that have significant early changes on brain imaging.
BerlinAges 18 years+ - NCT04864171Recruiting
Registry to study heart vessel imaging with a special light test
This registry collects images of coronary artery blockages during a routine heart procedure. It uses a special light-based imaging scan to help researchers understand how well the test shows artery lesions.
MiyazakiAges 20–95 - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04868578Recruiting
Vitamin PPI supplements for ectopic calcification in PXE
This trial studies whether taking PPI-type supplements can slow or reduce unwanted calcification in people with PXE. It’s meant to help manage disease changes caused by abnormal calcium deposits, based on your medical testing.
AngersAges 18–65 - NCT04871191RecruitingPhase 3
Salvage treatment for granulomatosis with polyangiitis flare
This Phase 3 trial studies “salvage” treatment for people with active granulomatosis with polyangiitis (GPA) whose standard treatments have not worked well enough. It aims to improve disease control and reduce the need for ongoing higher-dose steroids.
ParisAges 18 years+ - NCT04873583RecruitingPhase 3
High-dose steroids for children after a one-sided stroke
This trial tests whether high-dose steroids given soon after a stroke can improve outcomes for children. It is aimed at children whose stroke is caused by a one-sided blood-vessel problem seen on brain scans.
Randwick, New South WalesAges 6 months–17 years - NCT04873687Recruiting
ECP treatment for stable angina while waiting for heart care
This trial studies whether ECP (a non-surgical treatment that improves blood flow to the heart) can reduce symptoms in people with stable angina who may need or are waiting for heart bypass surgery, or are being managed with medicines instead. It may help you feel better and need less urgent care—if you meet the study’s medical and personal requirements.
Bandung, West JavaAges 18 years+ - NCT04874454Recruiting
Checks choking risk from a throat ultrasound after stroke
This study looks at whether using an ultrasound on the throat (laryngeal ultrasound) could cause choking in people who have had a recent stroke. If you recently had an acute stroke, they may test the safety of this monitoring approach for you.
Taipei, None SelectedAges 20 years+ - NCT04875429Recruiting
Study of a fenestrated aortic graft for certain aneurysms
This study checks how well a specially designed aortic graft (a fenestrated device) works for people with specific types of enlarged or fast-growing aortic aneurysms. It may help confirm whether the device is safe and effective for preventing aneurysm problems.
Birmingham, AlabamaAges 18 years+ - NCT04875936Recruiting
Neurofeedback therapy to improve reading after recent stroke
This trial studies whether a brain-training approach called neurofeedback can improve reading skills after a stroke that happened recently. It may help if you have clear reading and comprehension problems following a left-side stroke.
West Orange, New JerseyAges 18–80 - NCT04876339Recruiting
Sound-based training to improve walking after brain illness
This study tests whether using special sounds (sonification) during gait training can improve walking for people with stroke, Parkinson’s disease, or multiple sclerosis. It may help your walking speed, stamina (fatigue), and overall walking pattern.
PaviaAges Up to 80 years - NCT04877444RecruitingEarly Phase 1
Exercise program to improve arm recovery after stroke
This early-stage trial tests a special exercise approach meant to “prime” the brain and improve arm movement after a stroke. You may be eligible if you’re 6+ months out from a one-sided stroke and can safely do an exercise test.
Charleston, South CarolinaAges 50–90 - NCT04879069Recruiting
Registry study for recent high-risk blood clot in the lungs
This trial is a registry that collects information about people with a recent lung blood clot diagnosed by CT scan. It particularly focuses on higher-risk cases to better understand outcomes and care in the first 2 weeks after symptoms start.
Poznan, GreaterPolandAges 18 years+ - NCT04882488Recruiting
Testing heart scan measurements in severe aortic valve narrowing
This trial compares two pressure-based measurements of blood flow in the coronary arteries with a PET heart scan in people with severe aortic valve stenosis. It may help doctors choose the most accurate way to assess blood flow and guide care during valve treatment.
Bad Oeynhausen, North Rhine-WestphaliaAges 65 years+ - NCT04885985Recruiting
Check a new treatment for blocked leg arteries after procedures
This post-market study follows people with significant below-the-knee artery blockages to see how a treatment performs over time. It may help patients by confirming the safety and ongoing effectiveness of the device used for these leg artery problems.
Beijing, Beijing MunicipalityAges 18–75 - NCT04888039Recruiting
Living with myeloma follow-up study in West-Occitanie
This study follows people with symptomatic multiple myeloma who live in the West-Occitanie region. It aims to better understand patients’ experiences and needs over time, which may help improve care and support.
Toulouse, West-OccitanieAges 18 years+ - NCT04888247Recruiting
Testing a new mitral valve replacement for high-risk patients
This study checks whether an innovative device can safely replace a damaged mitral valve in people who are higher risk for open-heart surgery. It looks at how well the procedure and follow-up work for improving mitral leakage symptoms.
AuchenflowerAges 18 years+ - NCT04888741RecruitingPhase 2
Trial testing reduced immune T cells before stem cell transplant
This Phase 2 trial looks at a transplant approach that reduces harmful immune cells (T cells) before or during an allogeneic stem cell transplant. It may help lower the risk of transplant complications while still letting the donor immune system fight the blood cancer.
Cardiff, WalesAges 16–70 - NCT04888936Recruiting
Study families with genetic RAS syndromes, including adults and children
This study looks at people with certain inherited genetic conditions called RASopathies and their family members. It helps researchers understand these conditions and how genetic changes run in families, which may improve future care.
Bethesda, MarylandAges 1 month–99 years - NCT04889105Recruiting
Exercise coaching for leg artery disease using a phone app
This study tests whether a phone-based program can help improve walking in Veterans with peripheral artery disease (PAD) by guiding regular exercise. It aims to reduce leg symptoms by making walking practice safer and easier to stick with.
Decatur, GeorgiaAges 40 years+ - NCT04889872Recruiting
Watchful waiting or TAVR for moderate aortic valve narrowing
This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
Huntsville, AlabamaAges 65 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.