Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 10,008 recruiting studies in this area right now.
By phase
- Not applicable7,984
- Phase 2484
- Phase 4481
- Phase 3449
- Phase 1360
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke846
- Heart Failure563
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease371
- Multiple Myeloma331
- Atrial Fibrillation271
- Ischemic Stroke200
- Atrial Fibrillation (AF)143
- Acute Ischemic Stroke141
- Pulmonary Hypertension101
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic84
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic95
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital53
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California467
- Alabama197
- Massachusetts182
- Arizona174
- New York163
- Florida143
- Minnesota121
- Maryland120
- Illinois119
- Texas118
Recruiting studies10,005 total
- NCT07687186RecruitingPhase 3
Qishen Yiqi pills for chronic heart failure
This trial tests whether Qishen Yiqi Dripping Pills, a Chinese herbal medicine, can help people with chronic heart failure caused by coronary heart disease. It is for adults who have been on stable heart failure treatment for at least two weeks.
Bozhou, AnhuiAges 18–80 - NCT05160584Recruiting
Real-world treatment study for relapsed or refractory myeloma
This study follows people with multiple myeloma that has come back or stopped responding to treatment, and looks at how current care is used in real life. It may include people starting talquetamab, and aims to understand outcomes and treatment patterns outside of strict experimental settings.
LeobenAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Birmingham, AlabamaAges 18 years+ - NCT07684053Recruiting
Digital screening for irregular heartbeat to prevent stroke
This study tests if using a digital device (like a smartwatch or phone) can help find an irregular heartbeat called atrial fibrillation. Finding it early may help prevent stroke, especially in people over 65.
Innsbruck, TyrolAges 65 years+ - NCT06008795RecruitingPhase 2
Pain-block injection for headache after brain bleed
This study tests a pain-block injection (called a PPF-block) for severe headaches after a brain bleed (subarachnoid hemorrhage). It compares the injection to standard pain medicine to see if it reduces headache and the need for opioids.
Gainesville, FloridaAges 18–85 - NCT04750798Recruiting
Monitoring approved catheter devices during heart rhythm ablation
This study is observing people with common abnormal heart rhythms who are already scheduled for a catheter ablation using an approved Biosense Webster catheter. It aims to better understand real-world use and outcomes, without testing a new drug.
GrazAges Any age - NCT03756870Recruiting
Stent procedure vs best medical care for blocked heart arteries
This trial studies whether opening a completely blocked heart artery (a CTO) with a procedure and stent helps reduce areas of low blood flow in the heart, compared with the best medicines alone. It uses heart scans to find people likely to benefit and then checks results again at 6 months.
AmsterdamAges 18 years+ - NCT06281977RecruitingPhase 3
Dexmedetomidine for electrical storm in the ICU
This trial tests if a medication called dexmedetomidine (a sedative that can also stabilize heart rhythm) helps calm electrical storms—dangerous, repeated episodes of fast heartbeats. It is for people in the intensive care unit who are experiencing this emergency.
Rochester, MinnesotaAges 18 years+ - NCT04798261Recruiting
Long-term follow-up after clot removal for pulmonary embolism
This study tracks how patients do long-term after having a clot in the lung treated with a device called the Indigo Aspiration System. It aims to better understand safety and outcomes over time.
Long Beach, CaliforniaAges 18 years+ - NCT05963568RecruitingPhase 3
Prevent more strokes with a daily anti-clotting heart pill
This Phase 3 trial tests whether a daily “polypill” can reduce the chance of another stroke after a recent ischemic stroke. It may help people by improving several heart-and-blood-vessel risks at once, but only if it fits safely with their medical situation.
ParakouAges 18–100 - NCT07243184Recruiting
Polymer heart valve study for mitral valve disease
This trial is testing a new polymer artificial heart valve for people with severe mitral valve problems. It aims to see if this valve is safe and works well during surgical replacement.
BeijingAges 60 years+ - NCT07686341Recruiting
Precision oxygen monitor study for infants
This trial tests a new type of oxygen monitor (pulse oximeter) in babies under 1 year old. It helps doctors better track oxygen levels in critically ill infants to improve care.
Memphis, TennesseeAges birth–1 year - NCT05705804Recruiting
Comparing statins and ezetimibe for heart patients with metabolic syndrome
This trial tests if pitavastatin alone or with ezetimibe affects blood sugar differently than atorvastatin in people who have heart or blood vessel disease and metabolic syndrome but do not have diabetes.
SeoulAges Any age - NCT07682948RecruitingPhase 1
Drug interaction study of UIC202601 and UIC202602 in healthy volunteers
This trial tests how two experimental drugs, UIC202601 and UIC202602, interact with each other in the body. Healthy volunteers take both drugs to check for side effects and how the body processes them.
Anyang, Manan-guAges 19–54 - NCT07685106Recruiting
Cardiostory device test for heart failure in shortness of breath
This trial tests if a device called Cardiostory can tell if your shortness of breath (dyspnea) is caused by heart failure or something else. It's for people who started having trouble breathing in the last week.
Monastir, Monastir GovernorateAges 18 years+ - NCT05786274Recruiting
Predicting stroke risk after heart surgery using heart signals and MRI
This study looks at ways to predict harmful brain and blood-vessel side effects after heart surgery. It may help doctors identify higher-risk patients sooner so they can monitor them more closely.
San Donato Milanese, MilanAges 18 years+ - NCT05277519Recruiting
Rehab retraining for walking after stroke or brain injury
This study tests a rehab program aimed at improving how the brain learns movement, to help people walk more independently after a stroke or traumatic brain injury. It may help by targeting walking and movement control of the affected leg.
ParisAges 18–70 - NCT06183437RecruitingPhase 4
Can I stop heart meds after cancer therapy?
This trial tests whether it is safe to stop taking heart failure medications in people who developed heart weakness after cancer treatment but whose heart function has since recovered. It aims to see if stopping these drugs leads to any worsening of heart health.
Los Angeles, CaliforniaAges 18 years+ - NCT06127602Recruiting
Electrical stimulation plus walking for stroke recovery
This study tests whether adding a type of electrical stimulation to leg muscles during walking can improve walking ability for people who are at least 6 months past a stroke. If you have weakness on one side and can walk on a treadmill with some help, you may be able to join.
Chicago, IllinoisAges 18–90 - NCT06285279RecruitingPhase 1
CAR-T cell therapy for hard-to-treat autoimmune kidney diseases
This trial tests a new type of cell therapy called CAR-T cells that target two proteins (BCMA and CD19) to treat autoimmune kidney diseases that are not responding to standard treatments. The goal is to see if this therapy can help control the disease and improve kidney function.
Nanjing, JiangsuAges 18–65 - NCT07683585Recruiting
Comparing blood pressure drugs after heart stent placement
This trial compares two different combinations of blood pressure medicines to see which works better for people who have had a heart stent placed. It may help find the best treatment plan for controlling blood pressure after the procedure.
MoscowAges 50–70 - NCT07445841Recruiting
Exercise to protect the brain after a first stroke
This trial tests whether a structured exercise program can help prevent thinking and memory problems after a first stroke. It might help you keep your brain healthy if you join within the first six months after your stroke.
Hamilton, OntarioAges 40–80 - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT06335433Recruiting
Handgrip exercise frequency and blood pressure in hypertension
This study tests whether doing handgrip exercises (squeezing a device in your hand) can help lower blood pressure. You can join if your blood pressure is on the higher side, you've been on the same medications (if any) for at least 4 months, and you're generally healthy enough to exercise.
Swansea, WalesAges 18–65
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 10,008 recruiting cardiology studies from the U.S. registry right now, out of 15,355 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.